Estimating the Risk for Conversion from Mild Cognitive Impairment to Alzheimer's Disease in an Elderly Arab Community

Inzelberg, Rivka; Massarwa, Magda; Schechtman, Edna; Strugatsky, Rosa; Farrer, Lindsay A.; Friedland, Robert P.

doi:10.3233/jad-142871

Cited by 13 publications

(10 citation statements)

References 23 publications

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“…Previous reports showed that people who reverted from MCI to normal cognition were younger, which is consistent with the results of the present study . However, sex was not previously associated with reversion to normal cognition or progression to dementia, which differs from our findings . These results might differ because the present study was an intervention study rather than an observational study.…”

Section: Discussionsupporting

confidence: 87%

“…5,16 However, sex was not previously associated with reversion to normal cognition or progression to dementia, which differs from our findings. 5,16,17 These results might differ because the present study was an intervention study rather than an observational study. However, as this study did not include a control group, it was not clear whether there was a sex difference in the improvement of cognitive function by exercise training.…”

Section: Discussionmentioning

confidence: 78%

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Japanese version of the Montreal Cognitive Assessment cut‐off score to clarify improvement of mild cognitive impairment after exercise training in community‐dwelling older adults

Nara

Sugie

Takahashi

et al. 2018

Geriatrics Gerontology Int

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Aim: Physical exercise improves cognitive function in people with mild cognitive impairment (MCI). However, information about whether the degree of MCI before exercise training affects improvement in cognitive function is lacking. Therefore, we aimed to investigate the cut-off value in a MCI screening tool that predicts reversal to normal cognitive function after exercise training in older adults with MCI.Methods: Participants included 112 Japanese community-dwelling older adult outpatients (37 men, 75 women; mean age 76.3 years). We administered the Japanese version of the Montreal Cognitive Assessment (MoCA-J) before and after exercise training. MCI was defined as a MoCA-J score <26. All participants underwent exercise training 2 days per week for 6 months, according to American Heart Association guidelines.Results: The prevalence of MCI was 65.2%. After exercise training, 46.6% of participants with MCI reversed to normal cognitive function. The MoCA-J cut-off score to predict cognitive function potentially reversible to normal was 23, with receiver operating characteristic analysis showing an area under the curve of 0.80, sensitivity of 79.4% and specificity of 69.2%. Multiple logistic regression analysis to predict non-MCI after exercise training showed that MoCA-J score ≥23 (OR 6.9, P < .001), female sex (OR 3.4, P = .04) and age (OR 0.9, P = .04) were independent determinants. Conclusions:The MoCA-J cut-off score of 23 might be useful to predict cognitive function that is potentially reversible to normal among community-dwelling Japanese older adults with MCI. Geriatr Gerontol Int 2018; 18: 833-838.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 78%

Japanese version of the Montreal Cognitive Assessment cut‐off score to clarify improvement of mild cognitive impairment after exercise training in community‐dwelling older adults

Nara

Sugie

Takahashi

et al. 2018

Geriatrics Gerontology Int

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“…The prevalence of mild cognitive impairment in Taiwan was higher in women than that in men after adjusting for age, education level, and other common associated factors [24]. Similar findings were reported in several other studies [25,26]. Consistent with these studies' results, we found that the prevalence of CIND in northern China was higher in women than in men, with prevalence rates of 26.1% for women and 19.8% for men.…”

Section: Discussionsupporting

confidence: 81%

Sex Differences in the Prevalence of and Risk Factors for Cognitive Impairment No Dementia among the Elderly in a Rural Area of Northern China: A Population-Based Cross-Sectional Study

et al. 2018

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Background/Aims: The burden of dementia among women in China, especially among women from rural areas, has increased due to their longevity and lower education levels compared with that among men. Thus, we aimed to assess sex differences in the prevalence of cognitive impairment and its relevant determinants among rural residents in North China. Methods: Adults aged 60 years and older with cognitive impairment no dementia (CIND) were recruited to this study. Demographic characteristics, traditional risk factors, and lifestyle characteristics were obtained and analyzed on the basis of sex. Results: There were 1,295 individuals with CIND (489 [37.8%] men and 806 [62.2%] women). The prevalence of CIND was 23.3% overall (19.8% for men, 26.1% for women; p < 0.001). Age, education level, history of stroke, and social activity were significantly associated with CIND for both men and women. Widowed status compared to married status was an independent risk factor for CIND in men (OR [95% CI] 1.50 [1.14–1.98]; p = 0.004). Conclusion: These findings suggest that it is crucial to address the secondary prevention of stroke and to consider the psychological status among the elderly with low educational attainment in order to reduce the burden of CIND in China.

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“…Another study surveyed elderly aged 65 years or older in an Arab community in Israel. Of the 231 subjects with MCI that were re-examined after 1 year, 68 (23%) converted to dementia, including 65 AD cases [10] . These studies, however, were either with short follow-up period or with vague diagnosis based on insufficient neuropsychological tests (e.g., MMSE only).…”

Section: Discussionmentioning

confidence: 99%

Progression and predictors of mild cognitive impairment in Chinese elderly: A prospective follow‐up in the Shanghai Aging Study

Ding

Zhao

Guo

et al. 2016

Alz & Dem Diag Ass & Dis Mo

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IntroductionThe Shanghai Aging Study is a community-based study aiming to investigate the incidence and progression of cognitive decline in Chinese elderly, with the operational procedures and diagnostic criteria similar to cohort studies in developed countries.MethodsWe prospectively evaluated 362 individuals with mild cognitive impairment (MCI) diagnosed at baseline through a clinical and neuropsychological interview. Diagnoses of dementia and MCI were made using standard criteria via consensus diagnosis.ResultsThe conversion rate to dementia was 6.0 per 100 person-years, while the reversion rate to cognitive normal was 7.8 per 100 person-years. Amnestic MCI multiple domains was the most risky type for dementia (conversion rate: 14.2 per 100 person-years). Older age (hazard ratio [HR] = 1.09), apolipoprotein E (APOE ε4) (HR = 2.15), and low MMSE score (HR = 1.18) were predictors for dementia.DiscussionApproximately 6% of elderly with MCI progress to dementia annually. Prospective studies are needed to further examine risk and protective predictors and to seek proper interventions for cognitive decline.

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Estimating the Risk for Conversion from Mild Cognitive Impairment to Alzheimer's Disease in an Elderly Arab Community

Abstract: In this population, age, female gender, lack of formal education, and hypertension are risk factors for both AD and MCI. Conversion risk from MCI to AD could be estimated as a function of age, time interval between examinations, and hypertension.

Cited by 13 publications

References 23 publications

Japanese version of the Montreal Cognitive Assessment cut‐off score to clarify improvement of mild cognitive impairment after exercise training in community‐dwelling older adults

Japanese version of the Montreal Cognitive Assessment cut‐off score to clarify improvement of mild cognitive impairment after exercise training in community‐dwelling older adults

Sex Differences in the Prevalence of and Risk Factors for Cognitive Impairment No Dementia among the Elderly in a Rural Area of Northern China: A Population-Based Cross-Sectional Study

Progression and predictors of mild cognitive impairment in Chinese elderly: A prospective follow‐up in the Shanghai Aging Study

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