The properties of the QED-vacuum energy EV P under Coulomb super-criticality condition Z > Zcr,1 are explored in essentially non-perturbative approach. It is shown that in the supercritical region EV P is the decreasing function of the Coulomb source parameters, resulting in decay into the negative range as ∼ −Z 4 /R. The conditions, under which the emission of vacuum positrons can be unambiguously detected on the nuclear conversion pairs background, are also discussed. In particular, for a super-critical dummy nucleus with charge Z and R(Z) ≃ 1.2 (2.5 Z) 1/3 fm the lowest 1s-level dives into the lower continuum at Zcr,1 ≃ 170 (the model of uniformly charged ball) or Zcr,1 ≃ 173 (the spherical shell model), whereupon there appears the vacuum shell with the induced charge (-2|e|) and the QED-vacuum becomes charged, but in both cases the actual threshold for reliable spontaneous positrons detection is not less than Z * ≃ 210.