Estimating the prevalence of myelodysplastic syndromes in patients with unexplained cytopenias: A retrospective study of 322 bone marrows

Buckstein, Rena; Jang, Karen; Friedlich, Jessica; Zhang, Liying; Reis, Marciano D.; Chesney, Alden; Wells, Richard A.

doi:10.1016/j.leukres.2009.02.010

Cited by 53 publications

(42 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In view of the fact that RDW level is indicative of abnormal red blood cell survival and that it correlates with the presence of inflammatory states [18,19], this parameter has been investigated as prognostic factor in hematological malignancies [20][21][22][23][24][25][26]. Some recent studies and a meta-analysis have demonstrated that RDW is a potent predictor of all-cause mortality, including cancer-related deaths [4,11].…”

Section: Discussionmentioning

confidence: 99%

The Association between Red Cell Distribution Width and Mortality in Pediatric Acute Lymphoblastic Leukemia

Rafsanjani¹,

Falahati²,

Kiumarsi³

et al. 2017

J Neoplasm

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

The Association between Red Cell Distribution Width and Mortality in Pediatric Acute Lymphoblastic Leukemia

Rafsanjani¹,

Falahati²,

Kiumarsi³

et al. 2017

J Neoplasm

View full text Add to dashboard Cite

show abstract

“…Good natural history studies of ICUS are lacking. 9,11,74 In the largest study to date, ICUS evolved to MDS in a minority of cases; further conclusions were limited by a lack of long-term follow-up.…”

Section: Proposed Diagnostic Criteria For Mdsmentioning

confidence: 99%

Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes

Steensma

Bejar

Jaiswal

et al. 2015

Blood

1,570

1,296

View full text Add to dashboard Cite

Recent genetic analyses of large populations have revealed that somatic mutations in hematopoietic cells leading to clonal expansion are commonly acquired during human aging. Clonally restricted hematopoiesis is associated with an increased risk of subsequent diagnosis of myeloid or lymphoid neoplasia and increased all-cause mortality. Although myelodysplastic syndromes (MDS) are defined by cytopenias, dysplastic morphology of blood and marrow cells, and clonal hematopoiesis, most individuals who acquire clonal hematopoiesis during aging will never develop MDS. Therefore, acquisition of somatic mutations that drive clonal expansion in the absence of cytopenias and dysplastic hematopoiesis can be considered clonal hematopoiesis of indeterminate potential (CHIP), analogous to monoclonal gammopathy of undetermined significance and monoclonal B-cell lymphocytosis, which are precursor states for hematologic neoplasms but are usually benign and do not progress. Because mutations are frequently observed in healthy older persons, detection of an MDS-associated somatic mutation in a cytopenic patient without other evidence of MDS may cause diagnostic uncertainty. Here we discuss the nature and prevalence of CHIP, distinction of this state from MDS, and current areas of uncertainty regarding diagnostic criteria for myeloid malignancies.

show abstract

“…Accordingly, since RDW level indicates abnormal red blood cell survival but it correlates also with the presence of severe systemic inflammatory state, undernutrition and inadequate production of EPO (3,25), this parameter has been investigated as prognostic factor and marker of disease activity in hematological malignancies [i.e., lymphocytic and myeloid leukemia, multiple myeloma, lymphoma and myelodysplastic syndrome (MDS)] (26)(27)(28)(29)(30)(31)(32)(33).…”

Section: Role Of Rdw In Hematological Tumorsmentioning

confidence: 99%

Red cell distribution width and cancer

2016

View full text Add to dashboard Cite

Red cell distribution width (RDW) is an index which primarily reflects impaired erythropoiesis and abnormal red blood cell survival. In last years the interest in this marker has considerably grown and now a lot of data are available indicating that this simple and inexpensive parameter is a strong and independent risk factor for death in the general population. Moreover, several investigations have been performed to investigate the role of RDW in cardiovascular and thrombotic disorders. Contrarily, there are relatively few reports focusing on RDW in the area of oncology and to date none review have been performed in this specific field. As such, the aim of this narrative review is to summarize some interesting results obtained in studies performed in patients affected by solid and hematological tumors. Even if larger studies are needed before these preliminary findings can be generalized, it seems plausible to affirm that RDW can be useful by adding prognostic information in patients with oncologic disease.

show abstract

Estimating the prevalence of myelodysplastic syndromes in patients with unexplained cytopenias: A retrospective study of 322 bone marrows

Cited by 53 publications

References 24 publications

The Association between Red Cell Distribution Width and Mortality in Pediatric Acute Lymphoblastic Leukemia

The Association between Red Cell Distribution Width and Mortality in Pediatric Acute Lymphoblastic Leukemia

Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes

Red cell distribution width and cancer

Contact Info

Product

Resources

About