Estimating the number of HTLV-2 infected persons in the world

Murphy, Edward L.; Cassar, Olivier; Gessain, Antoine

doi:10.1186/1742-4690-12-s1-o5

Cited by 28 publications

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“…The Human T-cell lymphotropic virus type 1 (HTLV-1) and type 2 (HTLV-2) have a worldwide distribution, with at least 5–10 million people infected 1–4. The prevalence depends on the geographical area, and endemic regions for HTLV-1/2 infection have been reported in Asia and Africa, in the Australo-Melanesian region and Caribbean region and South America 2,3,5–7.…”

Section: Introductionmentioning

confidence: 99%

“…HTLV-1 has also been associated to a disabling myelopathy known as tropical spastic paraparesis or HTLV1-associated mielopathy (HAM/TSP), affecting 0.25–3% of the infected people depending on the geographical area 2,11,12. In contrast, HTLV-2 infection, also persisting for life, has not been clearly linked with pathologies, although the virus has been associated with some very rare cases of hairy cell leukemia, erythrodermatitis, and few cases of other neurological disorders 2,4,13. HTLV transmission is similar to other retrovirus like HIV, hepatitis B, and C viruses.…”

Section: Introductionmentioning

confidence: 99%

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<p>A high prevalence of human T-lymphotropic virus (HTLV 1/2) infection among Afro-descendants, Esmeraldas province, Ecuador – need for the implementation of surveys and control programs</p>

Mosquera-Herrera

Aspiazu-Miranda

Waard

et al. 2019

IDR

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Background: Infection with the Human T-cell lymphotropic virus (HTLV) type 1 and 2 is endemic in South America. Although there are reports of the presence of these retroviruses in Ecuador, the infection is usually neglected in healthcare settings and by public health authorities, and no actualized prevalence data are available. Objectives: This cross-sectional study aimed to estimate, using for the first time to our knowledge in Ecuador immunological and molecular biology methodologies, the prevalence of HTLV-1/2 infection in asymptomatic individuals from a potentially high-risk population of Afro-Ecuadorians in the Province of Esmeraldas. Study design: Two hundred and twenty-seven plasma samples from asymptomatic individuals were analyzed for the detection of the HTLV-1/2 virus with three methods: a commercial ELISA, an indirect immunofluorescence (IF) assay, and a nested-PCR. Results: The overall prevalence of HTLV-1/2 antibodies in this population, as determined with an ELISA, was 11.0%. Both the IF assay and the nested-PCR confirmed a prevalence of 3.5%. Conclusion: The high prevalence of HTLV-1/2 infection among the Afro-Ecuadorian population of Esmeraldas Province shows the need of the implementation of control and prevention interventions to overcome the further dissemination of the infection. To define the real problem of HTLV-1/2 infection in Ecuador, more prevalence studies have to be undertaken in other Afro-Ecuadorian populations and high-risk populations like the indigenous population of the Andes Mountains and the tropical Amazon region.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

<p>A high prevalence of human T-lymphotropic virus (HTLV 1/2) infection among Afro-descendants, Esmeraldas province, Ecuador – need for the implementation of surveys and control programs</p>

Mosquera-Herrera

Aspiazu-Miranda

Waard

et al. 2019

IDR

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“…In the State of Pará, which is in the northern region of Brazil and characterized by large areas of the Amazon rainforest, limited infrastructure, and low human development, the prevalence varies from 0.1 to 1.4%, reaching a peak of 3% among people who used illicit drugs (PWUDs) (de Aguiar et al, 2017;Guerra et al, 2018;Silva et al, 2018;Oliveira-Filho et al, 2019). The prevalence of HTLV-2 is lower than HTLV-1 in most places; however, it particularly affects specific populations, such as native Amerindian groups and PWUDs (Ishak et al, 1995;Catalan-Soares et al, 2005;Murphy et al, 2015;Braço et al, 2019).…”

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confidence: 99%

Prevalence and Molecular Epidemiology of Human T-Lymphotropic Virus (HTLV) Infection in People Living With HIV/AIDS in the Pará State, Amazon Region of Brazil

et al. 2020

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“…7 Although they are not routinely screened for, there are an estimated 10-20 million people infected with HTLV-1 or HTLV-2 worldwide. 8,9 In recognition of its growing public health importance, the WHO announced an ambitious global agenda to eliminate viral hepatitis as a public health threat by 2030. 7 However, routine testing and treatment availability unfortunately remain limited, especially in Sierra Leone and many of the high-burden countries in sub-Saharan Africa.…”

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confidence: 99%

Seroprevalence of Hepatitis B, Hepatitis C, and Human T-Cell Lymphotropic Virus Infections in HIV-Infected Patients in Sierra Leone

Yendewa

Sahr

Aguilera

et al. 2019

The American Journal of Tropical Medicine and Hygiene

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HIV coinfection with hepatitis B virus (HBV), hepatitis C virus (HCV), and human T-cell lymphotropic viruses 1 and 2 (HTLV-1 and HTLV-2) is common because of shared transmission routes. There is no published data on the prevalence of these infections in people living with HIV in Sierra Leone. We conducted a cross-sectional study of 211 HIV-positive patients aged ³ 18 years in Freetown, Sierra Leone, in November 2017. Plasma samples were analyzed using the chemiluminescent microparticle immunoassay (Architect System, Abbott ARCHITECT Analyzer, Abbott Park, IL. The majority were female (63.5%), with median age 36 years (interquartile range [IQR]: 32-44) and median CD4 count of 396 cells/μL (IQR: 214-534). Sixty patients (28.4%) were newly diagnosed and antiretroviral therapy (ART) naive; 151 patients (71.6%) were ART experienced. The prevalence of the hepatitis B surface antigen (HBsAg), total anti-hepatitis B core antibody, and anti-HCV was 21.7%, 82.9%, and 4.3%, respectively. No cases of HTLV-1 or HTLV-2 were detected. Male gender (P = 0.004) and CD4 < 350 cells/μL (P = 0.017) were associated with the HBsAg positive status.

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Estimating the number of HTLV-2 infected persons in the world

Cited by 28 publications

References 0 publications

<p>A high prevalence of human T-lymphotropic virus (HTLV 1/2) infection among Afro-descendants, Esmeraldas province, Ecuador – need for the implementation of surveys and control programs</p>

<p>A high prevalence of human T-lymphotropic virus (HTLV 1/2) infection among Afro-descendants, Esmeraldas province, Ecuador – need for the implementation of surveys and control programs</p>

Prevalence and Molecular Epidemiology of Human T-Lymphotropic Virus (HTLV) Infection in People Living With HIV/AIDS in the Pará State, Amazon Region of Brazil

Seroprevalence of Hepatitis B, Hepatitis C, and Human T-Cell Lymphotropic Virus Infections in HIV-Infected Patients in Sierra Leone

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