Estimating the extent of the health hazard posed by high-production volume chemicals.

Abstract

We used structure-activity relationship modeling to estimate the number of toxic chemicals among the high-production volume (HPV) group. We selected 200 chemicals from among the HPV chemical list and predicted the potential of each for its ability to induce a variety of adverse effects including genotoxicity, carcinogenicity, developmental, and systemic toxicity. We found a significantly less than expected proportion of toxic chemicals among the HPV sample when compared to a reference set of 10,000 chemicals representative of the universe of chemicals.

Guidance Document on the Validation of (Quantitative) Structure-Activity Relationship [(Q)SAR] Models

“…A model that gives highly accurate predictions for narrow chemical classes that are not covered by the regulatory inventory of interest would be of questionable value. A number of investigations have addressed the need to screen and prioritise chemical inventories established under different legislations in OECD member countries (Cunningham and Rosenkranz, 2001;Klopman et al, 2003;Hong et al, 2002). Among the most commonly screened regulatory inventories are those of the High Production Volume Chemicals, Existing Substances, and inventories of pesticides and biocides.…”

Using HPV Chemical Data to Develop QSARs for Non‐HPV Chemicals: Opportunities to Promote More Efficient Use of Chemical Testing Resources

“…While this is the first paper to propose the use of data from HPV chemicals to develop QSARs for non-HPV chemicals, it is not the first to discuss SARs or QSARs for HPV chemicals, see, e.g., Bol et al [39], Peijnenburg et al [40] and Cunningham and Rosenkranz [41].…”

“…Cunningham and Rosenkranz [41] selected 200 chemicals from among the HPV chemical list and predicted the potential of each for its ability to cause genotoxicity, carcinogenicity, developmental, and systemic toxicity. The incentive for making the predictions was the U.S. EPA×s willingness to consider test results for the HPV Program based on scientifically-justifiable SARs.…”