Estimating the effect of air pollution from a coal-fired power station on the development of children's pulmonary function

Dubnov, Jonathan; Barchana, Micha; Rishpon, Shmuel; Leventhal, Alex; Segal, Isaac; Carel, Rafael S.; Portnov, Boris A.

doi:10.1016/j.envres.2006.02.009

Cited by 32 publications

(20 citation statements)

References 32 publications

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“…As applied to this investigation, demarginated neutrophils will phagocytose microorganisms followed by a burst of highly reactive oxygen species mediated by MPO. 41 This enzyme is itself an antimicrobial system in which intercellular activity directs MPO and associated reactive oxygen species to the phagosome. 42 Relative to these experiments, extracellular release of MPO also occurs during phagocytosis or when the cell is attempting to phagocytose particulate.…”

Section: Discussionmentioning

confidence: 99%

Measured Pulmonary and Systemic Markers of Inflammation and Oxidative Stress Following Wildland Firefighter Simulations

Ferguson

Semmens

Dumke

et al. 2016

Journal of Occupational &Amp; Environmental Medicine

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Objective A controlled human exposure study was conducted to investigate the impact of inhalational exposures to wood smoke PM2.5 on measured concentrations of airway and systemic inflammatory biomarkers. Methods Mimicking wildland firefighter activities, 10 participants were exposed to three doses of wood smoke PM2.5 (filtered-air, 250 µg/m3, and 500 µg/m3) while exercising on a treadmill. Exhaled breath condensate (EBC) and blood plasma samples were obtained pre-, immediately post-, and 1-hour post-exposure. 8-isoprostane, pH, and myeloperoxidase were measured in EBC while H2O2, surfactant protein D, and pentraxin-3 (PTX3) were measured in both EBC and plasma. Results Only pH, 8-isoprostane, and PTX3 displayed significant changes when comparing pre- and post- exposures. Conclusions Markers of inflammation and oxidative stress, including PTX3, pH, and 8-isoprostane in EBC and/or plasma, are sensitive to wood smoke inhalation, with further investigations warranted.

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Section: Discussionmentioning

confidence: 99%

Measured Pulmonary and Systemic Markers of Inflammation and Oxidative Stress Following Wildland Firefighter Simulations

Ferguson

Semmens

Dumke

et al. 2016

Journal of Occupational &Amp; Environmental Medicine

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“…An indirect approach to estimate air pollution exposure, known as the IEE, which has become a popular research tool in recent years (see inter alia Dubnov et al 2007;Portnov et al 2007;Jerrett et al 2008;Kim et al 2009;Zou et al 2009), was used in the present study. According to this approach, the home addresses of children in the study cohort were geo-coded (i.e.…”

Section: Gis Mapping Of Children and Individual Exposure Estimatesmentioning

confidence: 99%

“…As indicated by several recent empirical studies (cf. inter alia McConnell et al 2006;Brauer et al 2007;Dubnov et al 2007;Portnov et al 2007;Morgenstern et al 2008), the IEE approach appears to be more sensitive to intra-area differences in individual exposure than the traditional ecological approach (based on aggregate exposure estimates for statistical areas and townships) for detecting a variety of health outcomes associated with environmental hazards.…”

Section: Introductionmentioning

confidence: 99%

High prevalence of childhood asthma in Northern Israel is linked to air pollution by particulate matter: evidence from GIS analysis and Bayesian Model Averaging

Portnov

Reiser

Karkabi

et al. 2012

International Journal of Environmental Health Research

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The medical records of 3922 school children residing in the Greater Haifa Metropolitan Area in Northern Israel were analyzed. Individual exposure to ambient air pollution (SO(2) and PM(10)) for each child was estimated using Geographic Information Systems tools. Factors affecting childhood asthma risk were then investigated using logistic regression and the more recently developed Bayesian Model Averaging (BMA) tools. The analysis reveals that childhood asthma in the study area appears to be significantly associated with particulate matter of less than 10 μm in aerodynamic diameter (PM(10)) (Odds Ratio (OR) = .11; P<0.001). However, no significant association with asthma prevalence was found for SO(2) (P >0.2), when PM(10) and SO(2) were introduced into the models simultaneously. When considering a change in PM(10) between the least and the most polluted parts of the study area (9.4 μg/m(3)), the corresponding OR, calculated using the BMA analysis, is 2.58 (with 95% posterior probability limits of OR ranging from 1.52 to 4.41), controlled for gender, age, proximity to main roads, the town of a child's residence, and family's socio-economic status. Thus, it is concluded that exposure to airborne particular matter, even at relatively low concentrations (40-50 μg/m(3)), generally below international air pollution standards (55-70 μg/m(3)), appears to be a considerable risk factor for childhood asthma in urban areas. This should be a cause of concern for public health authorities and environmental decision-makers.

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“…For instance, Bhopal et al stated that “one of the major concerns among the residents [⋯] was an apparent increase in the incidence of asthma in the area” [12]. Reference to previous studies showing over-incidences of cancer, mortality or asthma are also quoted by 11 studies [37, 40, 42, 45, 48, 49, 52, 53, 56]. For instance, in the area investigated by Halliday et al ., “the prevalence of childhood asthma [⋯] was approximately twice that of a control area [⋯] ” [42].…”

Section: Resultsmentioning

confidence: 99%

“…A majority of the studies focused on the respiratory health of children (17 studies), using questionnaires specifically defined for the study or standardized questionnaires such as the ISAAC questionnaire from the International Study of Asthma and Allergies in Childhood [39, 45, 47, 54], or the questionnaire from the American Thoracic Society (ATS) [40, 43]. Few studies used additional data from general practitioners (GPs) [12, 13, 49, 59].…”

Section: Resultsmentioning

confidence: 99%

A Review of the Epidemiological Methods Used to Investigate the Health Impacts of Air Pollution around Major Industrial Areas

Pascal

Bidondo

et al. 2013

Journal of Environmental and Public Health

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We performed a literature review to investigate how epidemiological studies have been used to assess the health consequences of living in the vicinity of industries. 77 papers on the chronic effects of air pollution around major industrial areas were reviewed. Major health themes were cancers (27 studies), morbidity (25 studies), mortality (7 studies), and birth outcome (7 studies). Only 3 studies investigated mental health. While studies were available from many different countries, a majority of papers came from the United Kingdom, Italy, and Spain. Several studies were motivated by concerns from the population or by previous observations of an overincidence of cases. Geographical ecological designs were largely used for studying cancer and mortality, including statistical designs to quantify a relationship between health indicators and exposure. Morbidity was frequently investigated through cross-sectional surveys on the respiratory health of children. Few multicenter studies were performed. In a majority of papers, exposed areas were defined based on the distance to the industry and were located from <2 km to >20 km from the plants. Improving the exposure assessment would be an asset to future studies. Criteria to include industries in multicenter studies should be defined.

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Estimating the effect of air pollution from a coal-fired power station on the development of children's pulmonary function

Cited by 32 publications

References 32 publications

Measured Pulmonary and Systemic Markers of Inflammation and Oxidative Stress Following Wildland Firefighter Simulations

Measured Pulmonary and Systemic Markers of Inflammation and Oxidative Stress Following Wildland Firefighter Simulations

High prevalence of childhood asthma in Northern Israel is linked to air pollution by particulate matter: evidence from GIS analysis and Bayesian Model Averaging

A Review of the Epidemiological Methods Used to Investigate the Health Impacts of Air Pollution around Major Industrial Areas

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