Estimating the burden of influenza‐associated hospitalizations and deaths in Central America

Descalzo, M.Á.; Clara, Wilfrido; Guzman, Guiselle; Mena, Ricardo; Armero, Julio; Lara, Bredy; Sáenz, Carlos Abel Córdova; Aragón, Anabela; Chacón, Rafael Barrera; El‐Omeiri, Nathalie; Méndez‐Rico, Jairo; Cerpa, Mauricio; Palekar, Rakhee; Jara, Jorge; Azziz‐Baumgartner, Eduardo

doi:10.1111/irv.12385

Cited by 25 publications

(41 citation statements)

References 14 publications

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“…Due to differences in surveillance systems, case definitions, access to care and healthcare‐seeking behaviour, direct comparisons of the incidence rates are not possible; however, similar trends were observed. As in previous reports,16, 17 the incidence of SARI was higher among younger (<16 years old) than older cases (≥16 years old) except for 2015/16 season, a season dominated by A(H1N1)pdm09 when the incidence of SARI was higher in the older cases (≥16 years old). The incidence of influenza‐associated SARI was similar between the age groups for all seasons except 2011/2012, when the rate in the <16‐year‐old group was 4 times higher than the older group.…”

Section: Discussionsupporting

confidence: 84%

Estimating burden of influenza‐associated influenza‐like illness and severe acute respiratory infection at public healthcare facilities in Romania during the 2011/12‐2015/16 influenza seasons

Gefenaitė

Pistol

Popescu

et al. 2017

Influenza Resp Viruses

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BackgroundInfluenza is responsible for substantial morbidity and mortality, but there is limited information on reliable disease burden estimates, especially from middle‐income countries in the WHO European Region.ObjectivesTo estimate the incidence of medically attended influenza‐associated influenza‐like illness (ILI) and hospitalizations due to severe acute respiratory infection (SARI) presenting to public healthcare facilities in Romania.Patients/MethodsSentinel influenza surveillance data for ILI and SARI from 2011/12‐2015/16, including virological data, were used to estimate influenza‐associated ILI and SARI incidence/100 000 and their 95% confidence intervals (95% CI).ResultsThe overall annual incidence of ILI and influenza‐associated ILI per 100 000 persons in Romania varied between 68 (95% CI: 61‐76) and 318 (95% CI: 298‐338) and between 23 (95% CI: 19‐29) and 189 (95% CI: 149‐240), respectively. The highest ILI and influenza incidence was among children aged 0‐4 years. We estimated that SARI incidence per 100 000 persons was 6 (95% CI: 5‐7) to 9 (95% CI: 8‐10), of which 2 (95% CI: 1‐2) to 3 (95% CI: 2‐4) were due to influenza. Up to 0.3% of the Romanian population were annually reported with ILI, and 0.01% was hospitalized with SARI, of which as much as one‐third could be explained by influenza.ConclusionsThis evaluation was the first study estimating influenza burden in Romania. We found that during each influenza season, a substantial number of persons in Romania suffer from influenza‐related ILI or are hospitalized due to influenza‐associated SARI.

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Section: Discussionsupporting

confidence: 84%

Estimating burden of influenza‐associated influenza‐like illness and severe acute respiratory infection at public healthcare facilities in Romania during the 2011/12‐2015/16 influenza seasons

Gefenaitė

Pistol

Popescu

et al. 2017

Influenza Resp Viruses

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“…Our estimates found among children under 5 years of age are similar to the global meta‐analysis for countries in the Americas (71 influenza‐associated hospitalizations per 100 000 persons‐years)27 and lower than the estimates from Central American countries (113 influenza‐associated hospitalization per 100 000 persons‐year) 12. Again this is likely attributable to various country‐level behaviors and surveillance system characteristics as explained above.…”

Section: Discussionsupporting

confidence: 76%

“…Our estimates for persons aged 65 years and older are greater than those reported in an analysis from Central America using the same data source (ie, pneumonia and influenza codes) and rate calculation methodology (44 per 100 000 persons‐year) 12. This might be due to differences in the ascertainment of cases that are tested for influenza or completeness of the hospital discharge and death databases.…”

Section: Discussioncontrasting

confidence: 59%

“…There are some strategies that allow for the estimation of influenza burden of disease using data from epidemiological surveillance when it is associated with the use of laboratory techniques for confirmation. In the Americas, several estimation analyses have been carried out using these methods, mainly in the United States, but also in Central America and the Caribbean 10, 11, 12, 13, 14, 15, 16, 17. In Chile, despite having a stable surveillance system with quality data, to date, no burden estimates have been made using these strategies.…”

Section: Introductionmentioning

confidence: 99%

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Estimating the burden of influenza‐associated hospitalizations and deaths in Chile during 2012‐2014

Sotomayor

Fasce

Vergara

et al. 2018

Influenza Resp Viruses

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BackgroundInfluenza is a vaccine preventable disease that causes important morbidity and mortality worldwide. Estimating the burden of influenza disease is difficult. However, there are some methods based in surveillance data and laboratory testing that can be used for this purpose.ObjectivesEstimating the burden of serious illness from influenza by means of hospitalization and death records during the period between 2012 and 2014, and using information from Severe Acute Respiratory Illness (SARI) surveillance.MethodsTo estimate the Chilean rate of influenza‐associated hospitalizations and deaths, we applied the influenza positivity of respiratory samples tested in six SARI surveillance sentinel hospitals to the hospitalizations and deaths from the records with ICD‐10 codes from influenza and pneumonia.ResultsAnnually, 5320 people are hospitalized for influenza and 447 die for this cause. The annual influenza‐associated hospitalization rate for the period was 71.5/100 000 person‐year for <5 years old, 11.8/100 000 person‐year for people between 5 and 64 years old; and 156.0/100 000 person‐year for ≥65 years. The annual mortality rate for the period was 0.08/100 000 person‐year for <5 years; 0.3/100 000 person‐year for people between 5 and 64 years; and 22.8/100 000 person‐year for ≥65 years.ConclusionsThis is the first study of influenza burden in Chile. Every year an important quantity of hospitalizations and deaths result from influenza infection. In countries in temperate zones, it is important to know the burden of influenza in order to prepare the health care network and to assess preventive intervention currently in practice and the new ones to implementing.

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“…Consistent with previous reports from Cambodia, countries in the region and globally, ( 7 , 21 , 24 ) influenza activity was detected throughout the year with peaks between March and December. In 2015 the predominant strain was influenza A(H3N2), whereas in 2016 A(H1N1)pdm09 and B co-circulated.…”

Section: Discussionsupporting

confidence: 92%

National burden of influenza-associated hospitalizations in Cambodia, 2015 and 2016

Ieng¹,

Tolosa

Tek

et al. 2018

WPSAR

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Introduction: The burden of influenza in Cambodia is not well known, but it would be useful for understanding the impact of seasonal epidemics and pandemics and to design appropriate policies for influenza prevention and control. The severe acute respiratory infection (SARI) surveillance system in Cambodia was used to estimate the national burden of SARI hospitalizations in Cambodia. Methods: We estimated age-specific influenza-associated SARI hospitalization rates in three sentinel sites in Svay Rieng, Siem Reap and Kampong Cham provinces. We used influenza-associated SARI surveillance data for one year to estimate the numerator and hospital admission surveys to estimate the population denominator for each site. A national influenza-associated SARI hospitalization rate was calculated using the pooled influenza-associated SARI hospitalizations for all sites as a numerator and the pooled catchment population of all sites as denominator. National influenza-associated SARI case counts were estimated by applying hospitalization rates to the national population. Results: The national annual rates of influenza-associated hospitalizations per 100 000 population was highest for the two youngest age groups at 323 for < 1 year and 196 for 1–4 years. We estimated 7547 influenza-associated hospitalizations for Cambodia with almost half of these represented by children younger than 5 years. Discussion: We present national estimates of influenza-associated SARI hospitalization rates for Cambodia based on sentinel surveillance data from three sites. The results of this study indicate that the highest burden of severe influenza infection is borne by the younger age groups. These findings can be used to guide future strategies to reduce influenza morbidity.

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Estimating the burden of influenza‐associated hospitalizations and deaths in Central America

Cited by 25 publications

References 14 publications

Estimating burden of influenza‐associated influenza‐like illness and severe acute respiratory infection at public healthcare facilities in Romania during the 2011/12‐2015/16 influenza seasons

Estimating burden of influenza‐associated influenza‐like illness and severe acute respiratory infection at public healthcare facilities in Romania during the 2011/12‐2015/16 influenza seasons

Estimating the burden of influenza‐associated hospitalizations and deaths in Chile during 2012‐2014

National burden of influenza-associated hospitalizations in Cambodia, 2015 and 2016

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