Estimating Recurrence of Spontaneous Preterm Delivery

Esplin, M. Sean; O’Brien, Elizabeth; Fraser, Alison; Kerber, Richard A.; Clark, Erin A.S.; Simonsen, Sara E.; Holmgren, Calla; Mineau, Geri; Varner, Michael W.

doi:10.1097/01.aoa.0000358389.77638.71

Cited by 48 publications

(85 citation statements)

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“…However, as expected, we found that maternal smoking and history of PTB were the main risk factors for PTB in cases. This is in accordance with the present literature [3,5,16,17,20,25]. Conversely, bacterial vaginosis and LLETZ conisation were not associated with PTB in our study, although they represent established risk factors for PTB.…”

Section: Discussionsupporting

confidence: 93%

Common Oxytocin Receptor Gene Polymorphisms and the Risk for Preterm Birth

et al. 2013

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Abstract.Oxytocin is crucially involved in the onset and maintenance of labor. We investigated the association between oxytocin receptor gene polymorphisms and preterm birth. The presence of four common oxytocin receptor gene polymorphisms (rs2254298, rs53576, rs2228485 and rs237911) was evaluated in one hundred women with preterm birth and one hundred healthy women using restriction fragment length polymorphism genotyping. No association was found between the presence of any individual oxytocin receptor gene polymorphism and preterm birth. In haplotype analysis, the haplotype combination of rs2254298 A allele, rs2228485 C allele and rs237911 G allele was found to be significantly associated with an increased risk of preterm birth (OR = 3.2 [CI 1.04-9.8], p = 0.043). In conclusion our findings suggest that a combination of three oxytocin receptor gene polymorphisms is associated with an increased risk for preterm birth. We propose further studies investigating the role of oxytocin receptor gene polymorphisms and preterm birth.

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Section: Discussionsupporting

confidence: 93%

Common Oxytocin Receptor Gene Polymorphisms and the Risk for Preterm Birth

et al. 2013

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“…Most women who deliver preterm, especially if they have had a previous sPTB, show CL <25 mm between 16 and 24 weeks. Short CL in pregnancy has been related to repetitive preterm birth and women with a short cervix during pregnancy are more likely to have had a previous sPTB [33,34]. The association between CL and sPTB is strongest in women with a prior sPTB, and this association is particularly evident when the previous sPTB occurred before 32 weeks [34][35][36].…”

Section: Patient Obstetrical and Medical Historymentioning

confidence: 99%

“…Patients with a history of sPTB show an increased risk of sPTB in subsequent pregnancies [16,33]. In the Preterm Prediction Study, Iams et al reported that in patients with a prior spontaneous preterm birth, the recurrence risk of preterm birth varies widely according to both fetal fibronectin and CL at 22-24 weeks [34].…”

Section: Patient Obstetrical and Medical Historymentioning

confidence: 99%

Cervical length for the prediction and prevention of preterm birth

Di¹,

Berghella

2013

Expert Review of Obstetrics & Gynecology

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“…[46][47][48][49][50][51] The risk of recurrent preterm birth increases as the gestational age of the previous preterm birth declines and as the number of previous preterm births increases, and thus is highest in women with more than 1 early preterm birth. 52 Women with more than 1 preterm birth are also more likely to have prior early (<32 weeks) preterm birth, to demonstrate clinical and ultrasound evidence of short cervix (sonographic length <25 mm, and Bishop score >3), and to have a positive fibronectin at 22-24 weeks.…”

Section: Recurrent Vs Nonrecurrent Preterm Birthmentioning

confidence: 99%

Care for Women with Prior Preterm Birth

Iams

2010

Preterm Birth

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Women who have delivered an infant between 16 and 36 weeks' gestation have an increased risk of preterm birth in subsequent pregnancies. The risk increases with more than 1 preterm birth and is inversely proportional to the gestational age of the previous preterm birth. African American women have rates of recurrent preterm birth that are nearly twice that of women of other backgrounds. An approximate risk of recurrent preterm birth can be estimated by a comprehensive reproductive history, with emphasis on maternal race, the number and gestational age of prior births, and the sequence of events preceding the index preterm birth. Interventions including smoking cessation, eradication of asymptomatic bacteriuria, progestational agents, and cervical cerclage can reduce the risk of recurrent preterm birth when employed appropriately. Keywordscerclage; prevention; progesterone; recurrent; preterm birth; risk estimation Efforts to reduce the incidence of preterm birth cannot yet be called successful but have produced sufficient information to justify management suggestions for clinicians, not only for strategies that do not work but also for those that do. The quality and number of clinical trials of interventions intended to reduce the incidence and/or morbidity of preterm birth has risen substantially in recent years, yielding data that can improve care for women at risk.An important advance has been the revision of the traditional model of preterm birth in which painful contractions or preterm membrane rupture were understood as the most common initial steps preceding cervical change. This concept has been challenged by observations from several clinical studies:• Drugs that arrest or inhibit uterine contractions can delay delivery but do not reliably reduce or prevent preterm birth. [1][2][3][4][5] • Assessment of contraction frequency is not a useful test to predict preterm birth, 6 and its use to detect and arrest initial or recurrent episodes of preterm labor does not affect the rate of preterm birth. [7][8][9] • Antibiotics that eradicate microorganisms associated with preterm birth also do not reliably reduce, and may sometimes increase, the incidence of preterm birth, especially in women with intact membranes. [10][11][12][13][14][15][16][17] • Progestational agents such as 17α-hydroxy-progesterone caproate reduce recurrent preterm birth in some women with a prior preterm birth, 18,19 especially those with early preterm birth 20 and short cervix, 21 but have no effect on preterm birth in multiple gestations. 22,23 NIH Public Access Author ManuscriptAm J Obstet Gynecol. Author manuscript; available in PMC 2013 May 09. NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript• Cervical cerclage can reduce recurrent preterm birth in women with a prior preterm birth and short cervix 24,25 but increases the risk of preterm birth in women with multiple gestation who also have a short cervix. 24 These findings suggest the following 4 substantive changes in the "contractions change the cervi...

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Estimating Recurrence of Spontaneous Preterm Delivery

Cited by 48 publications

References 0 publications

Common Oxytocin Receptor Gene Polymorphisms and the Risk for Preterm Birth

Common Oxytocin Receptor Gene Polymorphisms and the Risk for Preterm Birth

Cervical length for the prediction and prevention of preterm birth

Care for Women with Prior Preterm Birth

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