Estimating glomerular filtration rate (GFR) in diabetes: The performance of MDRD and CKD-EPI equations in patients with various degrees of albuminuria

Lovrenčić, Marijana Vučić; Biljak, Vanja Radišić; Božičević, Sandra; Prašek, Manja; Pavković, Pajica; Knotek, Mladen

doi:10.1016/j.clinbiochem.2012.07.115

Cited by 29 publications

(16 citation statements)

References 10 publications

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“…Those with microalbuminuria (UAE≥30<300 mg/24h) and macroalbuminuria (UAE≥300 mg/24h) were excluded from the study. Data on serum creatinine levels, age, sex and race were used to calculate the estimated GFR using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula, which has been shown to be accurate in determining renal function in diabetic patients with normal renal function [18,19]. Those with impaired estimated GFR (less than 60 ml min -1 1.73m -2 ) were excluded from the study.…”

Section: Introductionmentioning

confidence: 99%

Risk factors for development and progression of nonproliferative retinopathy in normoalbuminuric patients with type 1 diabetes

Bulum

Blaslov

Duvnjak

2014

Diabetes Research and Clinical Practice

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Section: Introductionmentioning

confidence: 99%

Risk factors for development and progression of nonproliferative retinopathy in normoalbuminuric patients with type 1 diabetes

Bulum

Blaslov

Duvnjak

2014

Diabetes Research and Clinical Practice

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“…Altered GFR and increased albuminuria are used as clinical markers for early kidney disease and diagnosis of diabetic nephropathy (6,64,65). The role of glomerular hyperfiltration for development of albuminuria has recently been questioned, but urinary protein excretion is still considered to predict progression of kidney disease (11,24,58,61,62).…”

Section: Discussionmentioning

confidence: 99%

Differences in susceptibility to develop parameters of diabetic nephropathy in four mouse strains with type 1 diabetes

Franzén

Friederich‐Persson

Fasching

et al. 2014

American Journal of Physiology-Renal Physiology

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One-third of diabetes mellitus patients develop diabetic nephropathy, and with underlying mechanisms unknown it is imperative that diabetic animal models resemble human disease. The present study investigated the susceptibility to develop diabetic nephropathy in four commonly used and commercially available mouse strains with type 1 diabetes to determine the suitability of each strain. Type 1 diabetes was induced in C57Bl/6, NMRI, BALB/c, and 129Sv mice by alloxan, and conscious glomerular filtration rate, proteinuria, and oxidative stress levels were measured in control and diabetic animals at baseline and after 5 and 10 wk. Histological alterations were analyzed using periodic acid-Schiff staining. Diabetic C57Bl/6 displayed increased glomerular filtration rate, i.e., hyperfiltration, whereas all other parameters remained unchanged. Diabetic NMRI developed the most pronounced hyperfiltration as well as increased oxidative stress and proteinuria but without glomerular damage. Diabetic BALB/c did not develop hyperfiltration but presented with pronounced proteinuria, increased oxidative stress, and glomerular damage. Diabetic 129Sv displayed proteinuria and increased oxidative stress without glomerular hyperfiltration or damage. However, all strains displayed intrastrain correlation between oxidative stress and proteinuria. In conclusion, diabetic C57Bl/6 and NMRI both developed glomerular hyperfiltration but neither presented with histological damage, although NMRI developed low-degree proteinuria. Thus these strains may be suitable when investigating the mechanism causing hyperfiltration. Neither BALB/c nor 129Sv developed hyperfiltration although both developed pronounced proteinuria. However, only BALB/c developed detectable histological damage. Thus BALB/c may be suitable when studying the roles of proteinuria and histological alterations for the progression of diabetic nephropathy.

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“…Serum creatinine was measured in fasting blood sample. Data on serum creatinine levels, age, sex and race were used to calculate the estimated glomerular filtration rate (eGFR) using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula, which was shown to be accurate in determining renal function in diabetic patients with normal renal function [18,19] . spectrophotometrically as previously described [20].…”

Section: Methodsmentioning

confidence: 99%

Dipeptidyl peptidase-4 activity is associated with urine albumin excretion in type 1 diabetes

Duvnjak

Perković

Blaslov

2017

Journal of Diabetes and its Complications

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Estimating glomerular filtration rate (GFR) in diabetes: The performance of MDRD and CKD-EPI equations in patients with various degrees of albuminuria

Cited by 29 publications

References 10 publications

Risk factors for development and progression of nonproliferative retinopathy in normoalbuminuric patients with type 1 diabetes

Risk factors for development and progression of nonproliferative retinopathy in normoalbuminuric patients with type 1 diabetes

Differences in susceptibility to develop parameters of diabetic nephropathy in four mouse strains with type 1 diabetes

Dipeptidyl peptidase-4 activity is associated with urine albumin excretion in type 1 diabetes

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