Estimating genetic and phenotypic parameters of cellular immune-associated traits in dairy cows

Denholm, Scott J.; McNeilly, Tom N.; Banos, Georgios; Coffey, Mike; Russell, George C.; Bagnall, Ainsley; Mitchell, Mairi C.; Wall, E.

doi:10.3168/jds.2016-11679

Cited by 25 publications

(19 citation statements)

References 67 publications

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“…Nevertheless, a combination of different indirect indicators of mastitis could be a more successful predictor of udder health. Thus, alternative traits derived from milk SCC, like the presence of at least one test-day (TD) SCC above specific thresholds in the lactation (Urioste et al 2010;Koeck et al 2012;Bobbo et al 2018), as well as blood serum proteins (Bobbo et al 2017;Cecchinato et al 2018) and cellular immuneassociated traits (Denholm et al 2017), have been explored as novel indicators of animal health. For instance, some of the new alternative SCC traits reported by Bobbo et al (2018) have already been incorporated into an aggregate selection index to reduce mastitis susceptibility in Italian Holsteins (Finocchiaro et al 2018).…”

Section: Introductionmentioning

confidence: 99%

Combining total and differential somatic cell count to better assess the association of udder health status with milk yield, composition and coagulation properties in cattle

Bobbo

Penasa

Cassandro

2020

Italian Journal of Animal Science

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Section: Introductionmentioning

confidence: 99%

Combining total and differential somatic cell count to better assess the association of udder health status with milk yield, composition and coagulation properties in cattle

Bobbo

Penasa

Cassandro

2020

Italian Journal of Animal Science

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“…Studies in humans and livestock have shown that variation in immune traits is often heritable; that is, a significant proportion of phenotypic variance can be attributed to additive genetic effects [3,8,11–15]. Genome-wide association studies (GWAS) in these systems have identified a number of genes of relatively large effect contributing to heritable variation, most notably the major histocompatibility complex (MHC) and cytokine genes [4,5,16–19].…”

Section: Introductionmentioning

confidence: 99%

“…A growing number of longitudinal studies in humans have found that high immunological diversity is maintained by high inter-individual variation, but that immune profiles of individuals are stable across longitudinal sampling [4,38–40]. Studies in cattle found that cellular based immune traits are highly repeatable, while antibody-based traits were less so [15,41]. Therefore, the ability to dissect the relative contributions of among- and within-individual variation in immune phenotype using longitudinal data collected in natural systems is a crucial step towards our understanding of the evolutionary and ecological causes and consequences of observed variation in immunity in the wild.…”

Section: Introductionmentioning

confidence: 99%

The genetic architecture of helminth-specific immune responses in a wild population of Soay sheep (Ovis aries)

et al. 2019

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Much of our knowledge of the drivers of immune variation, and how these responses vary over time, comes from humans, domesticated livestock or laboratory organisms. While the genetic basis of variation in immune responses have been investigated in these systems, there is a poor understanding of how genetic variation influences immunity in natural, untreated populations living in complex environments. Here, we examine the genetic architecture of variation in immune traits in the Soay sheep of St Kilda, an unmanaged population of sheep infected with strongyle gastrointestinal nematodes. We assayed IgA, IgE and IgG antibodies against the prevalent nematode Teladorsagia circumcincta in the blood plasma of > 3,000 sheep collected over 26 years. Antibody levels were significantly heritable (h2 = 0.21 to 0.57) and highly stable over an individual’s lifespan. IgA levels were strongly associated with a region on chromosome 24 explaining 21.1% and 24.5% of heritable variation in lambs and adults, respectively. This region was adjacent to two candidate loci, Class II Major Histocompatibility Complex Transactivator (CIITA) and C-Type Lectin Domain Containing 16A (CLEC16A). Lamb IgA levels were also associated with the immunoglobulin heavy constant loci (IGH) complex, and adult IgE levels and lamb IgA and IgG levels were associated with the major histocompatibility complex (MHC). This study provides evidence of high heritability of a complex immunological trait under natural conditions and provides the first evidence from a genome-wide study that large effect genes located outside the MHC region exist for immune traits in the wild.

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“…Исследования, проведенные в условиях современных молочных комплексов, оснащенных доильным оборудованием «DeLaval» и «Westfalia» показали (Kosyachenko et al, 2016), что сила влияния технологии на пожизненную продуктивность составила 21,1 %, при этом на величину неорганизованных факторов приходилось 48,0 %. Однако коммерциализация молочного скота сопровождается и рядом негативных последствий: ухудшением качества молока, снижением иммунного статуса животных, плодовитости, сокращением периода хозяйственного использования коров в стадах (Goncharenko, 2016;Denholm, et al, 2017;Charfeddine & Pérez-Cabal, 2016). Авторы (Donnik et al, 2010;Weber et al, 2013;Compton et al, 2016;De Vries, 2017) сообщают о том, что короткая длительность хозяйственного использования у высокопродуктивных коров связанна с более высокими обменными процессами в их организме, поскольку в сложных условиях они более склоны к заболеваниям и нарушениям репродуктивной функции, чем животные со средними показателями продуктивности, не исключая при этом влияния генетических факторов (Abdalla et al, 2016;VandeHaar et al, 2016;Tsuruta et al, 2017;Banos et al, 2017).…”

Section: продуктивное долголетие коров голштинской породыunclassified

Продуктивное Долголетие Коров Голштинской Породы Европейской Селекции В Условиях Промышленной Технологии

Milostiviy¹,

Vysokos²,

Кalinichenko³

et al. 2017

Ukr J Ecol

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The lifetime productivity of European Holstein cows and their offspring under conditions of industrial milk production technology was studied. It is established that the productive longevity of European Holstein cow offspring in the conditions of the industrial complex was reduced by 1.0 lactation (td = 5.6 or P≥ 0.999), an average of 2.6 lactations. The lifetime milk yield was lower by 20.9% (td = 2.6 or P≥0.99), and the yield of milk fat and protein by 23.0 (td = 3.3 or P≥ 0.999) and 24.1% (Td = 4.8 or P≥ 0.999). At the same time, the influence of origin on lifelong milk yield was 9.5% (P≥0.95), on fat content -22.7% (P≥0.999) and on milk protein -37.5% (P≥0.999). The variation coefficient (Cv = 12.1 ... 79.2%) of animal signs has a sufficient level for carrying out effective breeding work. Revealed high phenotypic and genotypic correlation coefficients between the indices of lifetime productivity (r = + 0.92 ... + 0.98) showed that the breeding of any signs will have a positive effect on others ones. The coefficients of productive qualities heredity (h2 = 0.18 ... 0.23), prove that breeding based on the lifetime productivity signs will have a positive effect on the progress in dairy cattle breeding. Evaluation of dairy cattle productive longevity has great scientific and practical importance. Studies were carried out on Holstein cows using the data of the dairy cattle management system "Orsek". Biometric processing was carried out with the help of Stat Soft software "Statistica 7.0". The advantage of the study lies in the fact that the Holstein of different origins were kept in the same environmental conditions. Intra-breed differences in lifelong productivity of imported cows were revealed. The lifetime milk yield of Danish animals exceeded the average by 1336 kg, fat by 73.4 and protein by 60.7 kg. However, the offspring of imported Hungarian cows were the most suitable for industrial technology. They surpassed the Danish and German opponents by 0.4 and 0.5 lactation in productive longevity, by 9213 and 9688 kg in lifetime milk yield, by 106 and 239 kg in fat and by 72 and 202 kg in milk protein. In general, in conditions of industrial milk production technology, the duration of first-generation cow productive life was reduced by 1.0 lactation (td = 5.6 or P≥ 0.999), in average it was 2.6 lactations. At the same time, the lifetime milk yield of imported animal offspring was significantly lower by 7167 kg, that is, by 20.9% -decreased from 34245 to 27078 kg (td = 2.6 or P≥0.99). As a consequence, the first generation cows' milk fat and protein were lower by 23.0 (td = 3.3 or P≥ 0.999) and 24.1% (td = 4.8 or P≥0.999). It was found that the variability of the signs (Cv) ranged from 14.7 ... 15.4 (protein content) to 42.0 ... 52.6% (milk yield), increasing in the first generation from 11.4 ... 16, 8 to 53.6 ... 56.1%, which indicates the possibility of carrying out effective breeding. Female offspring of imported cows have a low heritability in lifetime milk yield (h2 = 0.02 ... 0.18), in milk fat yield (h2 = 0...

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Estimating genetic and phenotypic parameters of cellular immune-associated traits in dairy cows

Cited by 25 publications

References 67 publications

Combining total and differential somatic cell count to better assess the association of udder health status with milk yield, composition and coagulation properties in cattle

Combining total and differential somatic cell count to better assess the association of udder health status with milk yield, composition and coagulation properties in cattle

The genetic architecture of helminth-specific immune responses in a wild population of Soay sheep (Ovis aries)

Продуктивное Долголетие Коров Голштинской Породы Европейской Селекции В Условиях Промышленной Технологии

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