2010
DOI: 10.1086/650754
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Estimating Attributable Mortality Due to Nosocomial Infections Acquired in Intensive Care Units

Abstract: Background.The strength of the association between intensive care unit (ICU)-acquired nosocomial infections (NIs) and mortality might differ according to the methodological approach taken.Objective.TO assess the association between ICU-acquired NIs and mortality using the concept of population-attributable fraction (PAF) for patient deaths caused by ICU-acquired NIs in a large cohort of critically ill patients.Setting.Eleven ICUs of a French university hospital.Design.We analyzed surveillance data on ICU-acqui… Show more

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Cited by 38 publications
(28 citation statements)
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References 39 publications
(18 reference statements)
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“…It has been reported from different studies that lower age, malnutrition, underlying diseases, P. aeruginosa infections, and VAP are related to the higher mortality rates of NIs (3,7,(25)(26)(27)(28). The presence of various risk factors in our study group, the predominance of VAP, and antibiotic-resistant Gram-negative pathogens, especially P. aeruginosa, as etiological agents were related to the high mortality rate.…”
mentioning
confidence: 48%
“…It has been reported from different studies that lower age, malnutrition, underlying diseases, P. aeruginosa infections, and VAP are related to the higher mortality rates of NIs (3,7,(25)(26)(27)(28). The presence of various risk factors in our study group, the predominance of VAP, and antibiotic-resistant Gram-negative pathogens, especially P. aeruginosa, as etiological agents were related to the high mortality rate.…”
mentioning
confidence: 48%
“…[1][2][3] Although the neonatal and paediatric HAI burden is well described in high-income settings (4 -8% prevalence), [4,5] the HAI burden in most African countries is unquantified. In a meta-analysis of HAI in low-middle-income countries (LMIC), the World Health Organization (WHO) identified only three studies of neonatal/paediatric HAI from Africa between 1995 and 2008 (none from South Africa (SA)).…”
Section: In Practicementioning
confidence: 99%
“…Nosocomial infections (NIs) are a major threat for hospitalized patients, particularly in intensive care units (ICUs), because they are associated with increased mortality and morbidity [1,2]. Analysis of data from large multicenter studies has the potential to improve our understanding of how patient- and ICU-level characteristics impact NI outcomes.…”
Section: Introductionmentioning
confidence: 99%