Estimating an EQ-5D-Y-3L Value Set for China

Abstract

Introduction The standard EQ-5D-Y-3L valuation protocol applies DCE data as the primary preference source to model the relative importance of dimensions while cTTO data served to anchor the DCE coefficients onto the QALY scale. This study aims to estimate an EQ-5D-Y-3L value set for China following this protocol, but with a larger cTTO design to better understand the role of cTTO data in estimating EQ-5D-Y-3L value sets. Methods In total, 150 choice sets and 28 EQ-5D-Y-3L health states were valued using DCE and cTTO methods with two independent samples, respectively. General public from 14 different regions were recruited using quota sampling method to achieve representativeness. We compared two modelling strategies: (1) fit the DCE data with mixed logit model with correlated coefficients and a subsequent mapping procedure for anchoring; (2) fit the DCE and TTO data jointly in a hybrid model. Two evaluation criteria (1) coefficient significance and monotonicity; (2) prediction accuracy of the observed cTTO values were used to select the value set. Results In total, 1476 individuals participated in the study, with 1058 participated the DCE interview and 418 participated the cTTO interview. The highest mean TTO value was 0.924 for state 11112 and the lowest mean TTO value was − 0.088 for state 33333. The hybrid model with an A3 term performed the best and was selected as the value set. Discussion Following the international protocol and using a larger cTTO design, this study established the EQ-5D-Y-3L value set using a hybrid model for China. Future EQ-5D-Y-3L valuation study could consider using a larger cTTO design for estimating the value set. Supplementary Information The online version contains supplementary material available at 10.1007/s40273-022-01216-9.

The RETRIEVE Checklist for Studies Reporting the Elicitation of Stated Preferences for Child Health-Related Quality of Life

“…This paper reports the first checklist for studies reporting values for HRQoL of children. There has been a notable increase in research aimed at producing values for child HRQoL in recent years; for instance, many value-sets for the EQ-5D-Y-3L (for example [ 18 , 22 – 26 ]) instrument have commenced or been completed since 2020 [ 27 ]. However, the methods being used to value the EQ-5D-Y-3L and other childhood HRQoL instruments vary widely [ 3 , 8 ], are not always fully reported, and the values can have quite different characteristics.…”

Efficient Designs for Valuation Studies That Use Time Tradeoff (TTO) Tasks to Map Latent Utilities from Discrete Choice Experiments to the Interval Scale: Selection of Health States for TTO Tasks

“…34 The protocol specifies a minimal set of 10 health states to be valued using the TTO, weighted toward the 2 ends of the scale, although in several countries, additional health states have been valued. 14,29,35,36 A recent commentary identified strengthening the design of the TTO component of the protocol-specifically, which states should be includedas a top priority for methodological research. 37 The implications of our work for the valuation of the EQ-5D-Y-3L are as follows.…”

Feasibility and cross-cultural validation of an adapted social skills group training programme (KONTAKT™ CHILD) for Chinese autistic children: a wait-list RCT protocol

“…Cost differences will be statistically tested, while resource usage differences will not be compared to prevent false positives. Quality-adjusted life year (QALY) will be calculated from EQ-5D-Y and CHU9D scores using validated algorithms for Chinese children and adolescents [60, 61]. Given potential non-normality in cost data, a non-parametric random forest permutation model will handle missing data.…”