Estimating adult cerebral oxygen saturation from time-resolved near-infrared spectroscopy measurements with few discrete wavelengths at a single source-detector distance

Cohen, David J.; Li, Natalie C.; Diop, Mamadou

doi:10.1117/12.2577340

Cited by 1 publication

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“…(2): μa(λ)=−m(λ)c/n,where m is the asymptotic slope of the natural logarithm of the DTOF, c is the speed of light in a vacuum, and n is the refractive index of the phantom (assumed to be 1.33 60 ). The definition of the tail of the DTOF varies in the literature; some suggest that the slope can be fit after the intensity of the DTOF falls below 50% to the right of the peak intensity, 64 whereas others suggest using later windows (10% to 2% 67 or 5% to 1% 68 , 69 ) to ensure that the asymptotic assumption is met 65 . Importantly, using a later window comes at the cost of SNR since the number of detected photons is lower 70 .…”

Section: Methodsmentioning

confidence: 99%

HyperTRCSS: A hyperspectral time-resolved compressive sensing spectrometer for depth-sensitive monitoring of cytochrome-c-oxidase and blood oxygenation

Li,

Ioussoufovitch,

Diop

2024

J. Biomed. Opt.

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Hyperspectral time-resolved (TR) near-infrared spectroscopy offers the potential to monitor cytochrome-c-oxidase (oxCCO) and blood oxygenation in the adult brain with minimal scalp/skull contamination. We introduce a hyperspectral TR spectrometer that uses compressive sensing to minimize acquisition time without compromising spectral range or resolution and demonstrate oxCCO and blood oxygenation monitoring in deep tissue.Aim: Develop a hyperspectral TR compressive sensing spectrometer and use it to monitor oxCCO and blood oxygenation in deep tissue.Approach: Homogeneous tissue-mimicking phantom experiments were conducted to confirm the spectrometer's sensitivity to oxCCO and blood oxygenation. Twolayer phantoms were used to evaluate the spectrometer's sensitivity to oxCCO and blood oxygenation in the bottom layer through a 10 mm thick static top layer. Results:The spectrometer was sensitive to oxCCO and blood oxygenation changes in the bottom layer of the two-layer phantoms, as confirmed by concomitant measurements acquired directly from the bottom layer. Measures of oxCCO and blood oxygenation by the spectrometer were highly correlated with "gold standard" measures in the homogeneous and two-layer phantom experiments. Conclusions:The results show that the hyperspectral TR compressive sensing spectrometer is sensitive to changes in oxCCO and blood oxygenation in deep tissue through a thick static top layer.

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