Estimating 1- and 5-year relative survival trends in colorectal cancer (CRC) in the United States: 2004 to 2014.

Abstract

587 Background: Patient survival is impacted by several factors, one of which is stage at diagnosis. From 1976 to 2014, CRC death rate in the United States (US) declined by 51%. This retrospective study was conducted using US Surveillance, Epidemiology and End Results (SEER) data to evaluate 1- and 5-year relative survival for patients with CRC by American Joint Committee on Cancer (AJCC) stage, age and sex at diagnosis. Methods: The study included adults (age ≥20 years) in the SEER-18 registry diagnosed with CRC in 2004-2014. One- and 5-year relative survival rates were stratified by AJCC stage, age group (20-64 vs. ≥65 years) and sex. Results: One- and 5-year survival was calculated by age and stage at diagnosis (Table), and by sex (data not shown). Overall, 5-year survival rates declined compared to 1-year rates, with the biggest decline observed in stage IV patients. Survival was higher in the younger cohort than in patients ≥65 years of age regardless of stage. Both men and women diagnosed with stage IIB CRC had lower 1- and 5-year survival compared to stage IIIA and IIIB groups, consistent with previous findings. Patients with stage IV had the lowest survival irrespective of age or sex. Conclusions: Overall trends in 1- and 5-year relative survival for CRC varied by AJCC stage, age and sex. Since survival is lowest among CRC patients diagnosed at stage IV, particularly in elderly patients, it reinforces the need for early diagnosis and availability of innovative late stage therapies in this population. [Table: see text]

Comparison of a Five-Year Survival and Cancer Recurrence between Laparoscopically Assisted and Open Colonic Resections due to Adenocarcinoma—A Single Centre Experience

“…However, age may work as a confounder [15]. Specifically, previous studies in colorectal cancer patients showed that survival is lower in patients aged 65 years or more, compared with patients younger than 65 years [16][17][18]. A stratified analysis of our study population produced a similar result (Table 3).…”

“…From the above findings, we can conclude that older patients in the OCS group and a higher number of deaths were not connected to malignant neoplasm in the OCS group, which surely increased the mortality in this group. Overall, the five-year survival of the enrolled patients was comparable with survival of similar patients (we excluded patients with stage IV disease) in other, larger studies researching colorectal cancer mortality [16,17].…”

Integrative analysis from multi‐centre studies identifies a function‐derived personalized multi‐gene signature of outcome in colorectal cancer

“…The AJCC TNM staging system and age are well‐known important prognostic factors . In the multivariate analysis conducted in the present study, TNM stage and age remained significantly associated with survival besides the FunPGS in the meta‐discovery and TCGA cohorts, indicating the independent and complementary value of TNM stage and age.…”

Should we invest in biological age predictors to treat colorectal cancer in older adults?

“…Despite the recent advances in early detection and introduction of new therapeutic means, such as neoadjuvant chemoradiation, the five-year survival rates for stage IV CRC are as low as 14.4% for patients aged <65 years and 7.4% for patients aged 65 years [44]. Recurrence rates for two-and five-year follow-up also remain high, ranging from 15 to 30% [45,46].…”