Estimates of visual impairment and its causes from the National Eye Survey in Malaysia (NESII)

Chew, Fiona Lee Min; Salowi, Mohamad Aziz; Mustari, Zuraidah; Husni, Mohd Aziz; Hussein, Elias; Adnan, Tassha Hilda; Ngah, Nor Fariza; Limburg, Hans; Goh, Pik-Pin

doi:10.1371/journal.pone.0198799

Cited by 61 publications

(56 citation statements)

References 17 publications

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“…It was estimated that approximately 8.4 million people were bilaterally blind from primary glaucoma in 2010, and this might increase to 11.1 million by 2020 [2]. The impact of the disease is also similar in our region, whereby the National Eye Survey II in Malaysia (2014) has shown an estimated 1.2% prevalence of blindness in those aged 50 and above [3], and 6.6% of them from glaucoma.…”

Section: Introductionmentioning

confidence: 95%

Evaluation of Refractive Status and Ocular Biometric Parameters in Primary Angle Closure Disease

Loh¹,

Kamaruddin²,

Bastion³

et al. 2020

Ophthalmic Res

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Introduction: The aim of the study was to evaluate the refractive status and ocular biometric parameters in subjects with angle closure in Malaysia. Methods: This cross-sectional study was conducted on 171 primary angle closure patients (268 eyes). Visual acuity, refraction, and ocular biometry (central anterior chamber depth [ACD], axial length [AL], and lens thickness) were recorded. Vitreous cavity length (VL) and relative lens position (RLP) were calculated. Results: A total of 92 Primary Angle Closure Suspect (PACS), 30 Primary Angle Closure (PAC), and 146 Primary Angle Closure Glaucoma (PACG) eyes were included. Chinese ethnicity formed the majority (n = 197, 73.5%), followed by Malay (n = 57, 21.3%) and Indian (n = 14, 5.2%). There was a significant female preponderance with a female to male ratio of 1.85. Mean age was 65.7 ± 7.7 years. Mean spherical equivalent was +0.33 ± 1.29 D. Approximately half (n = 137, 51%) of the eyes were hyperopic (spherical power ≥+0.5), with PACG having the highest percentage of hyperopia (n = 69, 50.4%). Myopia and emmetropia were present in 48 (17.9) and 83 (31%) eyes, respectively. Although AL and VL in myopia patients were significantly longer than emmetropic and hyperopic eyes (p < 0.001), the ACD was not significantly different (p = 0.427). While the RLP is smaller in myopic eyes, lens thickness was increased in hyperopic eyes. PACG was significantly higher in elderly patients compared to PACS and PAC (p = 0.005). A total of 37 (13.8%) eyes were blind (vision worse than 3/60) and 19 of them (51.3%) were female patients. Conclusion: A decrease in RLP is predictive of angle closure disease in myopic eyes, whereas increased lens thickness contributes to angle closure disease in hyperopic eyes.

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Section: Introductionmentioning

confidence: 95%

Evaluation of Refractive Status and Ocular Biometric Parameters in Primary Angle Closure Disease

Loh¹,

Kamaruddin²,

Bastion³

et al. 2020

Ophthalmic Res

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“…2 The World Health Organization estimated about 33% of the people >65 years have disabling hearing loss, whereas people with vision impairment or blindness are estimated at 2.2 billion people, with the majority of them being >50 years of age. 3,4 Researchers typically studied hearing loss and visual loss in isolation and in different groups of subjects, 5,6 making it impossible to determine how these two sensory losses interact with each other. In recent years, there has been increasing interest in people with concurrent losses of both senses, or dual sensory impairment (DSI).…”

Section: Introductionmentioning

confidence: 99%

“…Researchers typically studied hearing loss and visual loss in isolation and in different groups of subjects, 5,6 making it impossible to determine how these two sensory losses interact with each other. In recent years, there has been increasing interest in people with concurrent losses of both senses, or dual sensory impairment (DSI) 7,8 .…”

Section: Introductionmentioning

confidence: 99%

Prevalence and risk factors of dual sensory impairment among community‐dwelling older adults in Selangor: A secondary data analysis

Mah

Ishak

Rahman

2020

Geriatrics Gerontology Int

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The present study aimed to examine the prevalence of dual sensory impairment, and to identify its risk factors among community-dwelling older adults in Selangor. Methods: Secondary analysis was carried out on data collected by the Grand Challenge Project among older adults aged ≥65 years from Selangor. Data on sociodemographic information, medical history, cognitive function and functional performance were obtained through face-to-face interviews using standardized questionnaires. Visual acuity was measured using the Early Treatment Diabetic Retinopathy Study (ETDRS) chart while hearing was assessed using pure-tone audiometry. Descriptive analysis was used to measure the prevalence of the impairments, and logistic regression analysis was used to identify the risk factors. Results: The prevalence of dual sensory impairment and hearing impairment were at 10.5% and 76.2% respectively. Multivariate logistic regression analysis revealed that participants with lower cognitive scores were associated with dual sensory impairment (odds ratio, 0.90; 95% confidence interval, 0.83-0.98), while smoking was found associated with hearing impairment (odds ratio, 6.58; 95% confidence interval, 1.51-28.65). Conclusion: Dual sensory impairment is common among older adults in Selangor. The association between dual sensory impairment and cognitive function suggests the need to have visual and hearing screening on older adults for early detection particularly those at risk of cognitive impairment. The prevalence of hearing impairment was reported high among older adults and smokers appeared to be at higher risk of the impairment. Geriatr Gerontol Int 2020; 20: 911-916.

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“…Cataract is a disease of aging, affecting 17% of all people aged 40 and over (46,47), though many congenital or early-onset mutations are also known (48)(49)(50). Due to the high cost of surgery and lack of a therapeutic treatment, cataract remains the leading cause of blindness in the world (47,51).…”

Section: Introductionmentioning

confidence: 99%

Conformational catalysis of cataract-associated aggregation in a human eye lens crystallin occurs via interface stealing

Serebryany

et al. 2019

Preprint

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Human γD-crystallin (HγD) is an abundant and highly stable two-domain protein in the core region of the eye lens. Destabilizing mutations and post-translational modifications in this protein are linked to onset of aggregation that causes cataract disease (lens turbidity). Wild-type HγD greatly accelerates aggregation of the cataract-related W42Q variant, without itself aggregating. The mechanism of this "inverse prion" catalysis of aggregation remained unknown. Here we provide evidence that an early unfolding intermediate with an opened domain interface enables transient dimerization of the C-terminal domains of wildtype and mutant, or mutant and mutant, HγD molecules, which deprives the mutant's Nterminal domain of intramolecular stabilization by the native domain interface and thus accelerates its misfolding to a distinct, aggregation-prone intermediate. A detailed kinetic model predicts universal power-law scaling relationships for lag time and rate of the resulting aggregation, which are in excellent agreement with the data. The mechanism reported here, which we term interface stealing, can be generalized to explain how common domain-domain interactions can have surprising consequences, such as conformational catalysis of unfolding, in multidomain proteins. SignificanceMost known proteins in nature consist of multiple domains. Interactions between domains may lead to unexpected folding and misfolding phenomena. This study of human γD-crystallin, a two-domain protein in the eye lens, revealed one such surprise: conformational catalysis of misfolding via intermolecular domain interface "stealing." An intermolecular interface between the more stable domains outcompetes the native intramolecular domain interface. Loss of the native interface in turn promotes misfolding and subsequent aggregation, especially in cataractrelated γD-crystallin variants. This phenomenon is likely a contributing factor in the development of cataract disease, the leading worldwide cause of blindness. However, interface stealing likely occurs in many proteins composed of two or more interacting domains.

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Estimates of visual impairment and its causes from the National Eye Survey in Malaysia (NESII)

Cited by 61 publications

References 17 publications

Evaluation of Refractive Status and Ocular Biometric Parameters in Primary Angle Closure Disease

Evaluation of Refractive Status and Ocular Biometric Parameters in Primary Angle Closure Disease

Prevalence and risk factors of dual sensory impairment among community‐dwelling older adults in Selangor: A secondary data analysis

Conformational catalysis of cataract-associated aggregation in a human eye lens crystallin occurs via interface stealing

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