Estimates of Sepsis Prevalence and Outcomes in Adult Patients in the ICU in India

Hammond, Naomi; Kumar, Ashwani; Kaur, Parmeet; Vijayaraghavan, Bharath Kumar Tirupakuzhi; Ghosh, Arpita; Grattan, Sarah; Jha, Vivekanand; Mathai, Dilip; Venkatesh, Balasubramanian

doi:10.1016/j.chest.2021.12.673

Cited by 27 publications

(18 citation statements)

References 28 publications

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“…Several insights emerge from this study. First, the reported overall prevalence of sepsis was lower than in a recent study from India that used similar methods ( 10 ) and found a Sepsis-3–based prevalence of 33%. The lower prevalence in the present study may be due to different inclusion criteria, types of participating sites, or interpretations of the sepsis case definitions, or it may represent an underestimate of the true prevalence across Asia.…”

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confidence: 71%

Sepsis Epidemiology and Outcomes in Asia: Advancing the Needle

Vijayaraghavan

Adhikari

2022

Am J Respir Crit Care Med

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Improving sepsis outcomes will require national investments in performance improvement for early recognition and treatment, and in improving access to primary, secondary and tertiary healthcare. In addition, sepsis incidence and outcomes act as a barometer of a country's overall state of public health. Any improvements based on clinical care alone are likely to be small, unless parallel actions improve sanitation and hygiene, access to clean drinking water, vaccination, and poverty alleviation.

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confidence: 71%

Sepsis Epidemiology and Outcomes in Asia: Advancing the Needle

Vijayaraghavan

Adhikari

2022

Am J Respir Crit Care Med

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“…The pathogenesis of sepsis is very complex, including pathogen invasion, host immune response, and various tissue damage caused by their complex interaction. Sepsis is one of the most common causes of death in intensive care medicine [ 20 ]. Although there has been great progress in pathophysiology of sepsis, we still lack the early diagnostic indicator to minimize the incidence rate of sepsis.…”

Section: Discussionmentioning

confidence: 99%

Screening of Sepsis Biomarkers Based on Bioinformatics Data Analysis

Liang

et al. 2022

Journal of Healthcare Engineering

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Background and objectives. Sepsis is a life-threatening organ dysfunction caused by the imbalance of the body’s response to infection. Delay in sepsis diagnosis has become a primary cause of patient death. This study aims to identify potential biomarkers of sepsis based on bioinformatics data analysis, so as to provide new gene biomarkers for the diagnosis and treatment of sepsis. Methods. Gene expression profiles of GSE13904, GSE26378, GSE26440, GSE65682, and GSE69528 were obtained from the National Center for Biotechnology Information (NCBI). The differentially expressed genes (DEGs) were searched using limma software package. Gene Ontology (GO) functional analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis, and protein-protein interaction (PPI) network analysis were performed to elucidate molecular mechanisms of DEGs and screen hub genes. Results. A total of 108 DEGs were identified in the study, of which 67 were upregulated and 41 were downregulated. 15 superlative diagnostic biomarkers (CCL5, CCR7, CD2, CD27, CD274, CD3D, GNLY, GZMA, GZMH, GZMK, IL2RB, IL7R, ITK, KLRB1, and PRF1) for sepsis were identified by bioinformatics analysis. Conclusion. 15 hub genes (CCL5, CCR7, CD2, CD27, CD274, CD3D, GNLY, GZMA, GZMH, GZMK, IL2RB, IL7R, ITK, KLRB1, and PRF1) have been elucidated in this study, and these biomarkers may be helpful in the diagnosis and therapy of patients with sepsis.

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“…At present, the clinical use of bundled and target-guided treatment programs for patients with sepsis can delay the development of patients' disease, but there are still some emergency sepsis patients with high mortality. Therefore, early identification and evaluation of the prognosis of emergency sepsis patients Influencing factors are the current clinical concerns [ 3 ]. At present, only SOFA, A-Pache II score, and some serum markers are used to predict and evaluate the progression of sepsis, but due to liver dysfunction and the use of other specific drugs, the above indicators still have certain limitations.…”

Section: Introductionmentioning

confidence: 99%

The Value of Neutrophil/Lymphocyte Ratio Combined with Red Blood Cell Distribution Width in Evaluating the Prognosis of Emergency Patients with Sepsis

Lin

Zhang

Tang

et al. 2022

Emergency Medicine International

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Sepsis is a dysfunction of various organs caused by a dysfunctional host response induced by infection. In recent years, the mortality rate of sepsis patients, especially the mortality rate of septic shock patients still remains high. Due to the complexity and heterogeneity of sepsis, there is currently a lack of clinical biomarkers that can be widely used for the early assessment of sepsis. In order to find more concise and accurate biomarkers for timely and adequate intervention in sepsis, we explored the value of neutrophil/lymphocyte ratio (NLR) combined with red blood cell distribution width (RDW) in assessing the prognosis of emergency sepsis patients. The results showed that NLR and RDW were closely related to the prognosis of emergency sepsis patients. The combination of the two can evaluate the prognosis of patients with emergency sepsis, which deserves close attention from clinicians.

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Estimates of Sepsis Prevalence and Outcomes in Adult Patients in the ICU in India

Cited by 27 publications

References 28 publications

Sepsis Epidemiology and Outcomes in Asia: Advancing the Needle

Sepsis Epidemiology and Outcomes in Asia: Advancing the Needle

Screening of Sepsis Biomarkers Based on Bioinformatics Data Analysis

The Value of Neutrophil/Lymphocyte Ratio Combined with Red Blood Cell Distribution Width in Evaluating the Prognosis of Emergency Patients with Sepsis

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