Estimates of Chronic Kidney Diseases Associated with Proton-Pump Inhibitors Using a Retrospective Hospital-Based Cohort in Thailand

Pannoi, Tanavij; Promchai, Chissanupong; Apiromruck, Penjamaporn; Wongpraphairot, Suwikran; Yang, Chen-Chang; Pan, Wen Chi

doi:10.2147/ijnrd.s389238

Cited by 4 publications

(1 citation statement)

References 24 publications

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“… 107 , 108 Importantly, studies have also shown that compared with H2RAs, PPI use was significantly associated with an increased risk of developing AKI, CKD, and ESRD. 85 , 91 , 97 , 100 , 104 , 105 , 109 …”

Section: Ast- Associated S Ide ...mentioning

confidence: 99%

Multidisciplinary Consensus for Rationalizing the Use of Acid Suppressants in Children and Adults: CONFOR

Kher,

Wadhawan,

Wadhwa

et al. 2024

Euroasian Journal of Hepato-Gastroenterology

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A bstract The use of acid suppression therapy (AST) is a common approach for managing a wide spectrum of acid peptic disorders. Histamine type 2-receptor antagonists (H2RAs) and proton pump inhibitors (PPIs) are the most widely prescribed AST in routine clinical practice. However, an exponential surge in the prescriptions of PPIs, such as Omeprazole, Esomeprazole, Pantoprazole, Lansoprazole in recent years and their associated adverse effects have raised concern about their inappropriate and overuse, both in children and adults. To address these issues, a three-step modified Delphi polling process was employed to establish best practice consensus statements for rationalizing the use of acid suppressants. A multidisciplinary expert panel of 13 health professionals across medical specialties, including gastroenterologists, hepatologists, pediatric gastroenterologists, pediatricians, otolaryngologists, cardiologists, nephrologists, gynecologist and orthopedists actively contributed to this collaborative process of consensus development. The expert panel proposed 21 consensus statements providing best practice points on the general use and safety of acid suppressants based on a comprehensive review of scientific literature and clinical expertise. The panel also collaboratively developed a PPI deprescribing algorithm. Altogether, this consensus paper offers evidence-based recommendations and guidance for the rational use of acid suppressants with a blueprint for deprescribing PPIs. This consensus paper contributes to aiding primary care practitioners in improving patient outcomes and minimizing healthcare costs. Additionally, it enhances patient safety and curtail inappropriate usage. How to cite this article Prabhoo RY, Pai UA, Wadhwa A, et al . Multidisciplinary Consensus for Rationalizing the Use of Acid Suppressants in Children and Adults: CONFOR. Euroasian J Hepato-Gastroenterol 2024;14(1):99–119.

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Section: Ast- Associated S Ide ...mentioning

confidence: 99%

Multidisciplinary Consensus for Rationalizing the Use of Acid Suppressants in Children and Adults: CONFOR

Kher,

Wadhawan,

Wadhwa

et al. 2024

Euroasian Journal of Hepato-Gastroenterology

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Impact of Proton Pump Inhibitors on Kidney Function and Chronic Kidney Disease Progression: A Systematic Review

Parmar,

Kaleem,

Samuganathan

et al. 2023

Preprint

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Aim: The aim of this systematic review is to comprehensively assess and analyze the impact of proton pump inhibitors on kidney function and their potential role in the progression of chronic kidney disease. Through a meticulous examination of available literature, we aim to provide a clear understanding of the relationship between proton pump inhibitor use and kidney health, shedding light on potential risks, benefits, and contributing factors. Ultimately, this research aims to inform healthcare professionals and patients alike about the implications of proton pump inhibitors on kidney function, facilitate informed medical decisions, and improve patient care. Methods: We used the following medical subject headings (MeSH) terms with keywords like "irritable bowel syndrome" and "kidney injury" to gather data from the National Library of Medicine (PubMed), PubMed Central (PMC), and Google Scholar. Articles from the last 10 years, 2013 to 2023, were gathered for this systematic review. Results: The results indicate a complex relationship between proton pump inhibitors and kidney function, as well as the progression of chronic kidney disease. Conclusion: In the end, this systematic review shows that there is a link between long-term use of proton pump inhibitors and a higher risk of kidney problems. Patients and healthcare providers should weigh the benefits of proton pump inhibitor therapy against potential risks, especially in individuals with pre-existing kidney conditions, and consider alternative treatment options when appropriate. Regular monitoring of kidney function in proton pump inhibitor users may also be advisable to ensure early detection and management of any adverse effects.

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Association between Proton Pump Inhibitor Use and Risk of Incident Chronic Kidney Disease: Systematic Review and Meta-Analysis

Ang,

Chia,

Valladares

et al. 2024

Biomedicines

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Introduction: Proton pump inhibitors (PPIs) are among the most commonly prescribed medications. Recently, PPI use has been linked to the development of chronic kidney disease (CKD) and cardiovascular events. Our study aimed to investigate the relationship between PPI use and the incidence of chronic kidney disease using a systematic review and meta-analysis. Methods: We performed a comprehensive literature search in PubMed, Embase, and Cochrane databases from their inception until March 2024 for relevant studies. We compared outcomes between patients using PPIs, those not using PPIs, and those using histamine-2 receptor antagonists (H2RAs). Endpoints were pooled using the DerSimonian-and-Laird random-effects model as the hazard ratio (HR) with 95% confidence intervals (CIs). Results: Our analysis included twelve studies with a total of 700,125 participants (286,488 on PPIs, 373,848 not on PPIs, and 39,789 on H2RAs), with follow-up periods ranging from three months to 14 years. The current meta-analysis revealed that PPI use is associated with a statistically significant increased risk of incident CKD (HR: 1.26, 95% CI: 1.16–1.38, p < 0.001) compared with non-users. Moreover, the risk of incident CKD is significantly higher in patients with PPI use compared to H2RA use (HR: 1.34, 95% CI: 1.13–1.59, p < 0.001). The results remained unchanged in terms of magnitude and direction after a leave-one-out analysis for both outcomes. Conclusions: Our multifaceted analysis showed that PPI use was associated with a higher incidence of CKD when compared to non-PPI use and H2RA use, respectively. These findings advocate for heightened vigilance and judicious use of long-term PPIs. Further large prospective longitudinal studies are warranted to validate these observations.

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Estimates of Chronic Kidney Diseases Associated with Proton-Pump Inhibitors Using a Retrospective Hospital-Based Cohort in Thailand

Cited by 4 publications

References 24 publications

Multidisciplinary Consensus for Rationalizing the Use of Acid Suppressants in Children and Adults: CONFOR

Multidisciplinary Consensus for Rationalizing the Use of Acid Suppressants in Children and Adults: CONFOR

Impact of Proton Pump Inhibitors on Kidney Function and Chronic Kidney Disease Progression: A Systematic Review

Association between Proton Pump Inhibitor Use and Risk of Incident Chronic Kidney Disease: Systematic Review and Meta-Analysis

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