Estimated Prevalence and Incidence of Uterine Leiomyoma, and Its Treatment Trend in South Korean Women for 12 years: A National Population-Based Study

Lee, Minkyoung; Chung, Youn‐Jee; Kim, Hyun-Kyung; Hwang, Hye‐Jin; Park, Jee Yune; Shin, Inhye; Kim, Chaewon; Cho, Hyun-Hee; Kim, Mi-Ra; Jung, Chan-Kwon; Chae, Kyung‐Hee; Kim, Sukil; Kim, Mee‐Ran

doi:10.1089/jwh.2020.8398

Cited by 16 publications

(14 citation statements)

References 21 publications

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“…The prevalence of uterine fibroids is increasing in some populations, such as in African American women ( 22 ). However, its reported incidence is likely to be an underestimation, as many tumors are asymptomatic or slightly symptomatic and therefore remain undiagnosed ( 1 ).…”

Section: Epidemiology Risk/protective Factors Driver Mutations and Tu...mentioning

confidence: 99%

Comprehensive Review of Uterine Fibroids: Developmental Origin, Pathogenesis, and Treatment

et al. 2021

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Uterine fibroids are benign monoclonal neoplasms of the myometrium, representing the most common tumors in women worldwide. To date, no long-term or non-invasive treatment option exists for hormone-dependent uterine fibroids due to the limited knowledge about the molecular mechanisms underlying the initiation and development of uterine fibroids. This paper comprehensively summarizes the recent research advances on uterine fibroids, focusing on their risk factors, development origin, pathogenetic mechanisms, and treatment options. Additionally, we describe the current treatment interventions for uterine fibroids. Finally, future perspectives on uterine fibroids studies are summarized. Deeper mechanistic insights into tumor etiology and uterine fibroids’ complexity can contribute to the newer targeted therapies.

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Section: Epidemiology Risk/protective Factors Driver Mutations and Tu...mentioning

confidence: 99%

Comprehensive Review of Uterine Fibroids: Developmental Origin, Pathogenesis, and Treatment

et al. 2021

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“…This demonstrates the necessity to increase the minimally invasive approach for uterine leiomyoma treatment, such as uterine artery embolization (UAE), high intensity focused ultrasound (HIFU) [ 49 ], and transcervical fibroid ablation [ 50 ]. A similar South Korean study, which analyzed data collected over a 12-year period (2002–2013), found that the proportion of myomectomies increased by 2.24-fold (21% in 2002 to 47% in 2013), whereas the proportion of hysterectomies decreased by 0.62-fold (79% in 2002 to 49% in 2013) in their country [ 51 ]. Moreover, the researchers observed increased rates of the UAE and HIFU procedures.…”

Section: Discussionmentioning

confidence: 99%

“…While the proportion of minimally invasive procedures is increasing in developing and developed countries [ 47 , 51 ], the rate of laparoscopic procedures in Kazakhstani gynecological practice, according to the UNEHS database, is as low as 11.59%. The majority of them are performed in large cities.…”

Section: Discussionmentioning

confidence: 99%

The Prevalence, Indications, Outcomes of the Most Common Major Gynecological Surgeries in Kazakhstan and Recommendations for Potential Improvements into Public Health and Clinical Practice: Analysis of the National Electronic Healthcare System (2014–2019)

Sakko

Aimagambetova

Terzić

et al. 2022

IJERPH

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Objectives: Major gynecological surgeries are indicated for the treatment of female genital pathologies. It is key to examine trends in gynecologic surgical procedures and updated recommendations by international gynecological societies to find opportunities for improvement of local guidelines. To date, a very limited number of reports have been published on the epidemiology of gynecological surgeries in Kazakhstan. Moreover, some local guidelines for gynecological conditions do not comply with the international recommendations. Thus, this study aims to investigate the prevalence, indications, and outcomes of the most common major gynecological surgeries by analyzing large-scale Kazakhstani healthcare data, and identifying possible opportunities for improvement of the local public health and clinical practice. Methods: A descriptive, population-based study among women who underwent a gynecological surgery in healthcare settings across the Republic of Kazakhstan during the period of 2014–2019 was performed. Data were collected from the Unified Nationwide Electronic Health System (UNEHS). Results: In total, 80,401 surgery cases were identified and analyzed in the UNEHS database for a period of 6 years (2014–2019). The median age of the participants was 40 years old, with 61.1% in reproductive age. The most prevalent intervention was a unilateral salpingectomy—29.4%, with 72.6% patients aged between 18–34 years. The proportion of different types of hysterectomies was 49.4%. In 20% of cases, subtotal abdominal hysterectomy was performed due to uterine leiomyoma. The proportion of laparoscopic procedures in Kazakhstani gynecological practice is as low—11.59%. Conclusions: The Kazakhstani public health and gynecological care sector should reinforce implementation of contemporary treatment methods and up-to-date policies and guidelines. The overall trends in surgical procedures performed for gynecological pathologies, including uterine leiomyoma and ectopic pregnancy treatment, should be changed in favor of the minimally invasive methods in order to adopt a fertility-sparing approach.

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“…Traditionally, hysterectomy is an effective and definitive surgical treatment for uterine fibroid[ 6 ]. As the patient’s desire to retain the uterus increases regardless of fertility preservation, myomectomy and interventional treatments, which include myolysis, uterine artery embolization, and HIFU, tend to increase in all age groups, even in perimenopausal women[ 7 ].…”

Section: Discussionmentioning

confidence: 99%

Ventral hernia after high-intensity focused ultrasound ablation for uterine fibroids treatment: A case report

Park¹,

Choi²

2022

World J Clin Cases

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BACKGROUND High-intensity focused ultrasound (HIFU) ablation is a minimally invasive approach in gynecology that is used to manage uterine fibroids. Although this procedure is safe and effective, adverse outcomes are becoming a major problem. CASE SUMMARY We present a case of ventral hernia that occurred as a rare and delayed complication of HIFU ablation for uterine fibroids treatment. The patient came to the hospital with abdominal bloating that occurred 6 mo after ultrasound-guided HIFU ablation for managing uterine fibroids. The ventral hernia, which occurred due to atrophied muscle layers following the procedure, was confirmed by imaging studies and intraoperative findings. She required a hernia repair with mesh and hysterectomy for definitive treatment of uterine fibroid. CONCLUSION High-intensity ultrasound ablation should be performed only on appropriate candidates. Patients should be educated about potential complications of the procedure and the possibility of subsequent treatment. Post-procedural long-term follow-up for detecting delayed adverse effects is important.

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Estimated Prevalence and Incidence of Uterine Leiomyoma, and Its Treatment Trend in South Korean Women for 12 years: A National Population-Based Study

Cited by 16 publications

References 21 publications

Comprehensive Review of Uterine Fibroids: Developmental Origin, Pathogenesis, and Treatment

Comprehensive Review of Uterine Fibroids: Developmental Origin, Pathogenesis, and Treatment

The Prevalence, Indications, Outcomes of the Most Common Major Gynecological Surgeries in Kazakhstan and Recommendations for Potential Improvements into Public Health and Clinical Practice: Analysis of the National Electronic Healthcare System (2014–2019)

Ventral hernia after high-intensity focused ultrasound ablation for uterine fibroids treatment: A case report

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