Estimated Prevalence and Incidence of Dry Eye Disease Based on Coding Analysis of a Large, All-age United States Health Care System

Dana, Reza; Bradley, John L.; Guérin, Annie; Pivneva, Irina; Stillman, Ipek Özer; Evans, Amber; Schaumberg, Debra A.

doi:10.1016/j.ajo.2019.01.026

Cited by 153 publications

(168 citation statements)

References 21 publications

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“…Notably, there are several authors who have determined 2 broad categories of symptoms in the diagnosis of CVS [49,57]: a first group of internal symptoms (including blurred vision, diplopia or headache) generally caused by refractive, accommodative or vergence anomalies and a second group of external symptoms related to dry eye (including burning, itching, dryness or tearing). Female sex is one of the most consistent risk factors in the development of dry eye, becoming more significant with age [58,59]. Two studies conducted with North American populations of more than 39,000 women [55] and 25,000 men [56] showed that women had a 70% higher risk of dry eye than did men.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Computer Vision Syndrome and Its Relationship with Ergonomic and Individual Factors in Presbyopic VDT Workers Using Progressive Addition Lenses

Sánchez-Brau

Domenech

Brocal-Fernández

et al. 2020

IJERPH

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This cross-sectional study estimated computer vision syndrome (CVS) prevalence and analysed its relationship with video display terminal (VDT) exposure, as well as sociodemographic, refractive, environmental, and ergonomic characteristics in 109 presbyopic VDT workers wearing progressive addition lenses (PALs). Usual spectacles were measured with a lens analyser, and subjective refraction was performed by an optometrist. CVS was measured with the CVS-Q©. VDT exposure was collected. Ergonomic evaluations were conducted in a normal working posture looking at the screen. Air temperature and relative humidity were measured (thermohygrometer), and illumination was measured (luxmeter). Descriptive analysis and differences in CVS prevalence, as a function of the explanatory variables, were performed (chi-square test). Multivariate logistic regression was used to identify factors associated with CVS (OR and 95% CI). The mean age was 54.0 ± 4.8 years, and 43.1% were women. The mean hours of VDT use at work was 6.5 ± 1.3 hours/day. The prevalence of CVS was 74.3%. CVS was significantly associated with women (OR 3.40; 95% CI, 1.12–10.33), non-neutral neck posture (OR 3.27; 95% CI, 1.03–10.41) and altered workplace lighting (OR 3.64; 95% CI, 1.22–10.81). Providing training and information to workers regarding the importance of adequate lighting and ergonomic postures during VDT use is advised to decrease CVS and increase workplace quality of life.

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Section: Discussionmentioning

confidence: 99%

Prevalence of Computer Vision Syndrome and Its Relationship with Ergonomic and Individual Factors in Presbyopic VDT Workers Using Progressive Addition Lenses

Sánchez-Brau

Domenech

Brocal-Fernández

et al. 2020

IJERPH

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“…5 Similarly, in a large U.S. database, the overall prevalence of DED between 2003 and 2015, based on diagnostic codes and pharmacy claims, was 5.3%. 6 Both analyses found that the prevalence of DED was higher among women than men and increased with age. 5,6 Another large U.S. claims database analysis showed that DED represented the sixth most common ocular condition for which patients sought care.…”

Section: Introductionmentioning

confidence: 97%

Loteprednol Etabonate for the Treatment of Dry Eye Disease

Beckman

Katz

Majmudar

et al. 2020

Journal of Ocular Pharmacology and Therapeutics

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Dry eye disease (DED) is a common ocular condition that can impair vision and may adversely impact quality of life. Due to the inflammatory nature of this disorder, topical corticosteroids are an effective treatment option, particularly for moderate-to-severe DED when first-line treatments, such as ocular lubricants, are insufficient. Loteprednol etabonate (LE) is a retrometabolically designed corticosteroid with a low propensity to cause corticosteroid-related adverse effects, such as elevated intraocular pressure (IOP). This review was conducted to provide an assessment of published studies on the use of LE for treatment of inflammation associated with DED. Twelve prospective and 2 retrospective studies evaluating LE ophthalmic suspension 0.5% and 2 prospective studies evaluating LE ophthalmic gel 0.5% were identified. LE given as monotherapy or with artificial tears (AT) improved signs of DED, especially among patients with a more pronounced inflammatory component, and also improved DED symptoms compared to baseline and/or control. Treatment with LE before cyclosporine A (CsA) therapy reduced stinging upon CsA initiation and provided more rapid relief of DED signs and symptoms than CsA plus AT alone. In patients with meibomian gland dysfunction, LE alone, or in addition to eyelid scrubs/warm compresses, reduced clinical signs and symptoms, and tear proinflammatory cytokine levels. Overall, LE was safe and well tolerated, with minimal effects on IOP. While larger and longerterm studies are warranted, these data support the use of LE as a safe and effective treatment option for DED.

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“…But the direct interaction between blood vessels and nerves in the cornea, especially during inflammation, has not been studied . Dry eye disease (DED) is the most common ocular surface inflammatory disease with an overall prevalence of 5.28% in the US population . Both human and animal studies have shown structural and functional alterations of corneal nerves in DED .…”

Section: Introductionmentioning

confidence: 99%

Sensory neurons directly promote angiogenesis in response to inflammation via substance P signaling

2020

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Blood vessels and nerves travel together to supply most tissues in the body. However, there is a knowledge gap in the mechanisms underlying the direct regulation of angiogenesis by nerves. In the current study, we examined the regulation of angiogenesis by sensory nerves in response to inflammation using the cornea, a normally avascular and densely innervated ocular tissue, as a model. We used desiccating stress as an inflammatory stimulus in vivo and found that sub‐basal and epithelial nerve densities in the cornea were reduced in dry eye disease (DED). We established a co‐culture system of trigeminal ganglion sensory neurons and vascular endothelial cells (VEC) and found that neurons isolated from mice with DED directly promoted VEC proliferation and tube formation compared with normal controls. In addition, these neurons expressed and secreted higher levels of substance P (SP), a proinflammatory neuropeptide. SP potently promoted VEC activation in vitro and blockade of SP signaling with spantide I, an antagonist of SP receptor Neurokinin‐1, significantly reduced corneal neovascularization in vivo. Spantide I and siRNA knockdown of SP abolished the promotion of VEC activation by DED neurons in vitro. Taken together, our data suggested that sensory neurons directly promote angiogenesis via SP signaling in response to inflammation in the cornea.

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Estimated Prevalence and Incidence of Dry Eye Disease Based on Coding Analysis of a Large, All-age United States Health Care System

Cited by 153 publications

References 21 publications

Prevalence of Computer Vision Syndrome and Its Relationship with Ergonomic and Individual Factors in Presbyopic VDT Workers Using Progressive Addition Lenses

Prevalence of Computer Vision Syndrome and Its Relationship with Ergonomic and Individual Factors in Presbyopic VDT Workers Using Progressive Addition Lenses

Loteprednol Etabonate for the Treatment of Dry Eye Disease

Sensory neurons directly promote angiogenesis in response to inflammation via substance P signaling

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