Abstract:Aim: To test the hypothesis that intensive insulin treatment and optimal glycaemic control are not fully protective against reduction of insulin sensitivity in children with type 1 diabetes.
Material and methods:Cohort study of 78 normal-weight patients with prepubertal onset (T 0 ) and follow-up waves at 1 (T 1 ), 5 (T 5 ), 10 (T 10 ), and 12 (T 12 ) years; matched for age and sex to 30 controls at T 12 . Estimated insulin sensitivity (eIS) by three formulae; ultrasound evaluation of para and perirenal fat th… Show more
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