Estimated glucose disposal rate demographics and clinical characteristics of young adults with type 1 diabetes mellitus: A cross-sectional pilot study

Nishtala, Revathi; Kietsiriroje, Noppadol; Karam, Mohammad; Ajjan, Ramzi; Pearson, S. Vere

doi:10.1177/1479164120952321

Cited by 15 publications

(11 citation statements)

References 14 publications

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“…Furthermore, we found significant interactions between eGDR and sex, age and anti-diabetes/hypertension drugs on risk of CVD. However, significant associations between eGDR with risk of CVD were observed in all subgroups, which was consistent with previous reported studies [ 29 – 31 ]. The present study provides a more valid appraisal of the relationship between eGDR and CVD, stroke and cardiac events.…”

Section: Discussionsupporting

confidence: 93%

Estimated glucose disposal rate and risk of cardiovascular disease: evidence from the China Health and Retirement Longitudinal Study

et al. 2022

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Objectives Previous studies had reported that insulin resistance (assessed by estimated glucose disposal rate; eGDR) was associated with higher risk of cardiovascular events (CVD) in diabetes patients. The aim of present study was to investigate the potential association between eGDR and CVD in general population. Methods The China Health and Retirement Longitudinal Study with 8,267 individuals were included in analysis. Participants were divided into four subgroups according to eGDR quartile. Cox proportional hazards regression models were used to examine the associations of eGDR with CVD (stroke or cardiac events). Results During 6 years of follow-up, a total of 1,476 respondents experienced a CVD (494 stroke and 1,110 cardiac events). In multivariable-adjusted analyses, the corresponding hazard ratio (95% confidence intervals) for the highest eGDR versus lowest quartile of eGDR was 0.58(0.49–0.67) for CVD. Each 1-SD increase of eGDR was associated with 16% (HRs = 0.84; 0.79–0.88) decreased risk of CVD. There was also a significant linear association between eGDR and CVD (P for linearity < 0.001). Similar associations were also found between eGDR and stroke and cardiac events. Conclusion A higher eGDR (a measure of insulin resistance) was associated with a decreased risk of CVD, stroke and cardiac events in general Chinese population, suggesting that eGDR could be considered as a preferential predictor and treatment target of CVD. Future well-designed prospective clinical studies are needed to verify our findings and to assess the effect of eGDR interventions in CVD prevention and therapy.

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Section: Discussionsupporting

confidence: 93%

Estimated glucose disposal rate and risk of cardiovascular disease: evidence from the China Health and Retirement Longitudinal Study

et al. 2022

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“…This was similar to study conducted by Mihaela L. Bîcu et al who found that obese patients had lower eGDR in comparison with lean subjects (19). Higher insulin doses and an increase in the rate of hypoglycemia may be possible causes for development of obesity and subsequent insulin resistance in T1DM cases (20).…”

Section: Discussionsupporting

confidence: 90%

Serum Selenoprotein P level is not indicative of Insulin Resistance in Children and Adolescents with Type 1 Diabetes Mellitus: Single Center Experience

Soliman

Kadr²,

Hassanein

2022

Pediatric Sciences Journal

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Background: Selenium has an anti-diabetic action as it an insulin-mimetic and antioxidant nutrient. Selenoprotein P (SeP) is an extracellular glycoprotein, that was linked to insulin resistance (IR). Aim: To validate of serum SeP as a measure for insulin resistance in patients with type 1 diabetes mellitus (T1DM). Methods: This prospective case-control study included 45 children and adolescents with T1DM and 45 healthy children and adolescents. Serum SeP was measured by ELISA and compared to estimated glucose disposal rate (eGDR) as a measure of insulin resistance. Results: Mean ± SD of SeP level was higher in T1DM patients than control group (59.78 ± 59.38 ng/ml, 55.57 ± 7.6 ng/ml, respectively), this difference was statistically insignificant (p= 0.642). SeP demonstrated significant positive correlations with duration of diabetes (r=0.413, p=0.005), high density lipoproteins (r=0.496, p=0.001) and glycosylated hemoglobin (r=0.357, p=0.016). There were statistically significant differences in eGDR between cases and controls (7.78±3.08 mg/kg/min, 12.53±0.91 mg/kg/min, respectively, (p= 0.001). There was no correlation between SeP level and eGDR values (IR indicator). Conclusion: Serum SeP level in T1DM patients was not indicative of IR. Higher serum SeP level are associated with longer duration and poor control of T1DM.

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“…Apart from micro-and macro-vascular complications, events like acute coronary syndrome are related to abnormal eGDR [7]. Also, individuals with type 1 diabetes mellitus (T1DM) and low eGDR have altered cholesterol and triglycerides [8]. These studies substantiate the significance of eGDR as an easy alternative tool for determining insulin resistance and to predict metabolic dysfunctions in a large population.…”

Section: Introductionmentioning

confidence: 61%

Estimated glucose disposal rate (eGDR) in rural Bangladeshi population and its correlation with cardiometabolic risks

Tomalika

Tagar

Afroz

et al. 2023

IMC Journal of Medical Science

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Background and objectives: For decades type 2 diabetes mellitus (T2DM) and insulin resistance (IR) are increasingly gaining importance as an underlying mechanism for increased risk of cardiovascular diseases (CVD). IR is related to various cardiometabolic adverse effects. Hyperinsulinemic-euglycemic clamp technique, the gold standard method for measuring IR, is an invasive and complex procedure. Estimation of glucose disposal rate (eGDR) is an easy alternative tool for measuring IR. There is no known study on eGDR level in Bangladeshi native population. Therefore, this study was undertaken to determine the eGDR values in a healthy working rural Bangladeshi population. Materials and methods: Six villages were selected purposively as the study sites. All healthy working people aged ≥20 years in selected rural community were considered eligible. Those who consented to participate in the study were enrolled. Investigations included a) interviewing for social and clinical history, b) anthropometry and measurement of blood pressure and d) estimation of HbA1c and biochemical indices. The eGDR (mg/kg/min) was calculated using formula: eGDR = 21.158 − (0.09 * WC) − (3.407 * HT) − (0.551 * HbA1c); where WC = waist circumference in cm, HT = hypertension (yes = 1/no = 0), and HbA1c = HbA1c (%). Results: A total of 93 (m/w = 29/64) participants were enrolled in the study. The prevalence rates of hypertension, diabetes and metabolic syndrome (MSyn) were 34%, 31.1% and 16.1%, respectively. The mean eGDR value was 9.9 (±0.149; 95% CI: 9.62–10.2) mg/kg/min. Most of the values of biophysical characteristics were normal. The comparison between participants with and without MSyn showed that the former had significantly lower eGDR (9.05±1.24 vs.10.10±1.37, p<0.01). Inverse correlations of eGDR with the obesity, glycemia and lipidemia (weight, waist, FBG, T-chol, and TG) were significant. Declining eGDR were significant with rising WHR, WHtR, TG/HDLR and T-chol/HDLR (for all, p<0.05). Conclusions: The study revealed the level of eGDR in a healthy working people of a rural community of Bangladesh. Moreover, eGDR was found to decrease significantly with the increasing cardiometabolic risks. The study revealed a higher prevalence of hypertension, diabetes and metabolic syndrome in apparently healthy working people highlighting susceptibility of Bangladeshi natives to non-communicable diseases. IMC J Med Sci. 2023; 17(2):005. DOI: https://doi.org/10.55010/imcjms.17.015 *Correspondence: M Abu Sayeed, Department of Community Medicine, Ibrahim Medical College, 1/A, Ibrahim Sarani, Segunbagicha, Dhaka 1000, Bangladesh. Email: sayeed1950@gmail.com

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Estimated glucose disposal rate demographics and clinical characteristics of young adults with type 1 diabetes mellitus: A cross-sectional pilot study

Cited by 15 publications

References 14 publications

Estimated glucose disposal rate and risk of cardiovascular disease: evidence from the China Health and Retirement Longitudinal Study

Estimated glucose disposal rate and risk of cardiovascular disease: evidence from the China Health and Retirement Longitudinal Study

Serum Selenoprotein P level is not indicative of Insulin Resistance in Children and Adolescents with Type 1 Diabetes Mellitus: Single Center Experience

Estimated glucose disposal rate (eGDR) in rural Bangladeshi population and its correlation with cardiometabolic risks

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