Estimated Glomerular Filtration Rate Is an Easy Predictor of Venous Thromboembolism in Cancer Patients Undergoing Platinum-Based Chemotherapy

Ferroni, Patrizia; Guadagni, Fiorella; Laudisi, Anastasia; Vergati, Matteo; Riondino, Silvia; Russo, Antonio; Davı̀, Giovanni

doi:10.1634/theoncologist.2013-0339

Cited by 8 publications

(11 citation statements)

References 26 publications

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“…Finally, a recent study investigating real-world features associated with cancer-related VTE showed that serum creatinine can be considered an independent indicator of increased VTE risk during platinum-based chemotherapy [154], confirming previous findings demonstrating that estimated glomerular filtration rate is associated with an increased VTE risk in cancer outpatients treated with platinum compounds, even under normal serum creatinine values [155].…”

Section: Vte Biomarkerssupporting

confidence: 75%

Predicting VTE in Cancer Patients: Candidate Biomarkers and Risk Assessment Models

Riondino

Ferroni

Zanzotto

2019

Cancers

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Risk prediction of chemotherapy-associated venous thromboembolism (VTE) is a compelling challenge in contemporary oncology, as VTE may result in treatment delays, impaired quality of life, and increased mortality. Current guidelines do not recommend thromboprophylaxis for primary prevention, but assessment of the patient’s individual risk of VTE prior to chemotherapy is generally advocated. In recent years, efforts have been devoted to building accurate predictive tools for VTE risk assessment in cancer patients. This review focuses on candidate biomarkers and prediction models currently under investigation, considering their advantages and disadvantages, and discussing their diagnostic performance and potential pitfalls.

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Section: Vte Biomarkerssupporting

confidence: 75%

Predicting VTE in Cancer Patients: Candidate Biomarkers and Risk Assessment Models

Riondino

Ferroni

Zanzotto

2019

Cancers

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“…Interestingly, reduced estimated glomerular filtration rate even under normal serum creatinine values has been shown to associate with an increased risk of VTE. 39 …”

Section: Discussionmentioning

confidence: 99%

Real-world features associated with cancer-related venous thromboembolic events

et al. 2018

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BackgroundThe incidence of venous thromboembolism (VTE) is 1–2/1000 individuals. Patients with cancer, especially during chemotherapy, are at enhanced risk, but real-world data on factors associated with VTE events are still scarce.AimThe aim of this retrospective study was to survey the incidence of VTE based on a large hospital database, and to identify comorbidities and features associated with VTE events. We focused on cancer-related VTE events and on factors indicating increased VTE risk during chemotherapy.MethodsThe cohort included patients treated at Turku University Hospital during years 2005–2013. Health information was derived and analysed from multiple electronic databases. The diagnoses of VTE and all comorbidities, including type of cancer, were based on International Classification of Diseases 10th Revision coding. For further analysis, we focused on 16 common types of cancers treated with chemotherapy. Age, gender, surgery, radiotherapy, distant metastasis, available laboratory values and platinum-based chemotherapy were evaluated for VTE group, and associations were estimated by Cox regression analyses.ResultsThe entire database contained information from 495 089 patients, of whom 5452 (1.1%) had a VTE diagnosis. Among individuals with VTE, 1437 (26.4%) had diagnosis of coronary heart disease and 1467 (26.9%) had cancer diagnosis. Among 7778 patients with cancer treated with chemotherapy, 282 (3.6%) had a VTE, platinum-based chemotherapy being a major risk factor (HR 1.77, 95% CI 1.40 to 2.24, p<0.001). In multivariate analysis, elevated blood neutrophil counts (>3.25×109 cells/L, HR 1.96, 95% CI 1.33 to 2.89, p<0.001) and plasma creatinine (>62.5 μmol/L; HR 1.60, 95% CI 1.21 to 2.13, p=0.001) values were independent indicators of increased VTE risk during chemotherapy.ConclusionsLongitudinal electronic health record analysis provides a powerful tool to gather meaningful real-world information to study clinical associations, like comorbidities, and to identify markers associated with VTE. The combination of various clinical and laboratory variables could be used for VTE risk evaluation and targeted prevention.

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“…The use of a general screening strategy is appealing, because it could provide the opportunity for prophylactic treatment, reducing the event rates in at-risk cancer patients. 100 Indeed, one multivariate analysis reported that eGFR (<90 mL/ min/1.73 m²) was the only independent predictive factor of VTE occurrence in a cohort of 322 consecutive patients with primary or relapsing/recurrent solid cancers who were receiving different standard combinations of platinum-based regimens. 100 The authors suggested that pretreatment eGFR could serve as a simple and cost-effective predictor of venous thromboembolic events in cancer patients.…”

Section: Discussionmentioning

confidence: 99%

Thrombosis and kidney disease in cancer: comorbidities defining a very high risk patient: A position paper from the Cancer & the Kidney International Network

Launay‐Vacher

Scotté

Riess

et al. 2018

Journal of Onco-Nephrology

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CKD is highly frequent in cancer patients. In total, 11.8%-25% of cancer patients had glomerular filtration rate (GFR) < 60 mL/min/1.73 m², and half had abnormal GFR (<90 mL/min/1.73 m²). 1-6 Furthermore, CKD patients are at higher risk to develop cancer. It is now established that the incidence of cancer is higher among CKD patients 7-11 than among the general population. Furthermore, CKD is an independent risk factor of the reduced overall survival in cancer patients. 2 Cancer patients are more prone to VTE. 12 Cancer patients have a prothrombotic state resulting from the synergic activity of factors involved in the so-called Virchow's triad: stasis of the blood, vascular injury and blood hypercoagulability, which affect the haemostatic process, including platelet functions and clotting cascade. 13 Furthermore,

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Estimated Glomerular Filtration Rate Is an Easy Predictor of Venous Thromboembolism in Cancer Patients Undergoing Platinum-Based Chemotherapy

Cited by 8 publications

References 26 publications

Predicting VTE in Cancer Patients: Candidate Biomarkers and Risk Assessment Models

Predicting VTE in Cancer Patients: Candidate Biomarkers and Risk Assessment Models

Real-world features associated with cancer-related venous thromboembolic events

Thrombosis and kidney disease in cancer: comorbidities defining a very high risk patient: A position paper from the Cancer & the Kidney International Network

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