Estimated dietary pesticide exposure from plant-based foods using NMF-derived profiles in a large sample of French adults

Abstract

Purpose: This study, conducted in participants of the NutriNet-Santé cohort, aims to identify dietary pesticide exposure profiles (derived from Non-negative Matrix Factorization) from conventional and organic foods among a large sample of general population French adults.Methods: Organic and conventional dietary intakes were assessed using a self-administered semi-quantitative food frequency questionnaire. Exposure to 25 commonly used pesticides was evaluated using food contamination data from Chemisches und Veterinäruntersuchungsamt Stuttgart accounting for farming system (organic or conventional). Dietary pesticide exposure profiles were identified using Non-Negative Matrix factorization (NMF), especially adapted for non-negative data with excess zeros. The NMF scores were introduced in a hierarchical clustering process.Results: Overall, the identified clusters (n=34,193) seemed to be exposed to the same compounds with gradual intensity. Cluster 1 displayed the lowest energy-intake and estimated dietary pesticide exposure, high organic food (OF) consumption (23.3%) and a higher proportion of male participants than other groups. Clusters 2 and 5 presented intermediate energy intake, lower OF consumption and intermediate estimated pesticide exposure. Cluster 3 showed high conventional fruits and vegetable (FV) intake, high estimated pesticide exposure, and fewer smokers. Cluster 4 estimated pesticide exposure varied more across compounds than for other clusters, with highest estimated exposures for acetamiprid, azadirachtin, cypermethrin, pyrethrins, spinosad. OF proportion in the diet was the highest (31.5%).Conclusion: Estimated dietary pesticide exposures appeared to vary across the clusters and to be related to OF proportion in the diet.

Oxidative Stress in NAFLD: Role of Nutrients and Food Contaminants

“…Various epidemiological studies reported a correlation between occupational exposure to these products and the development of pathologies, such as cancers, neurodegenerative diseases, and metabolic disorders [108][109][110][111]. Moreover, recent population studies (Nutrinetcohort in France) showed that the consumption of organic food correlated with a significant decreased risk of metabolic disease and cancer [112][113][114]. In addition, pesticides are bioactive compounds that exert an impact on various pathways underlying diseases [115].…”

Halving food-related greenhouse gas emissions can be achieved by redistributing meat consumption: Progressive optimization results of the NutriNet-Santé cohort

“…First, on the environmental level as organic production systems also exhibit improved energy efficiency (60), better biophysics and biological quality of soils (57,61) and are valuable for plant and animal biodiversity (57,60,61). Second, on the sanitary level, as high plant-based diets based on organic agriculture may lead to much lower exposure to pesticide residues (22,62,63), motivating the promotion of plant products produced without synthetic pesticides in the new French food-based dietary guidelines (64).…”

Expression, Characterization, Fermentation, Immobilization, and Application of a Novel Esterase Est804 From Metagenomic Library in Pesticide Degradation

“…The degradation ability of PYRs by recombinant Est804 was determined. Cypermethrin (CYP), fenpropathrin (FE), and lambda-cyhalothrin (LCT), which are frequently used for agricultural products and environments ( Cámara et al, 2020 ; Rebouillat et al, 2021 ; Xiao et al, 2021 ), were used as the degradation substrates, and GC-2010PLUS gas chromatography equipment produced by Shimadzu Company in Japan was used for the quantitative analysis. The standard mixture of CYP, FE, and LCT was prepared with a BR buffer solution of pH 7.5 to obtain a final concentration of 6 mg/L.…”