Estimated dietary intake of polyphenols in European adolescents: the HELENA study

Wisnuwardani, Ratih Wirapuspita; Henauw, Stefaan De; Androutsos, Odysseas; Forsner, Maria; Gottrand, Frédéric; Huybrechts, Inge; Knaze, Viktoria; Kersting, Mathilde; Donne, Cinzia Le; Marcos, Ascensión; Molnár, Denés; Rothwell, Joseph A.; Scalbert, Augustin; Sjöstróm, Michael; Widhalm, Kurt; Moreno, Luís A.; Michels, Nathalie

doi:10.1007/s00394-018-1787-x

Cited by 42 publications

(56 citation statements)

References 48 publications

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“…In terms of food sources, coffee and tea (especially in the UK) were the main contributors of HCAs (caffeoyl‐ and feruloyl‐quinic acids). In the adolescent study, the mean daily total polyphenol intake (329 mg) was much lower compared to the studies in adult populations (Table ). Flavonoids were much better represented (75–76% of total polyphenols) than phenolic acids (17–19%).…”

Section: Dietary Intake Of Hydroxycinnamic Acids and Associated Healtmentioning

confidence: 65%

“…As expected, a large heterogeneity in terms of mean intake and ranking of polyphenol classes has been seen among the different investigated cohorts. Two recent multi‐country European studies in adults (EPIC) and adolescents (HELENA) confirmed the variability of polyphenol intake at European level. In the adult study, the mean total polyphenol daily intake was the highest in Denmark (1786 mg for men and 1626 mg for women) and the lowest in Greece (744 mg in men and 584 mg in women).…”

Section: Dietary Intake Of Hydroxycinnamic Acids and Associated Healtmentioning

confidence: 73%

“…The main food sources were fruit, chocolate products, and fruit and vegetable juices. The differences compared to adult studies are not surprising, considering that coffee (the main source of phenolic acids in European adults) was not frequently consumed by adolescents …”

Section: Dietary Intake Of Hydroxycinnamic Acids and Associated Healtmentioning

confidence: 90%

“…Regarding dietary polyphenol intake, several studies have been identified in the recent literature reporting the daily intake of various classes and specific compounds in different regions of the world . The results for individual countries are summarized in Table .…”

Section: Dietary Intake Of Hydroxycinnamic Acids and Associated Healtmentioning

confidence: 99%

“…Furthermore, using observational data to identify the specific compounds from the hundreds of polyphenols in our diet which can provide the greatest effect in terms of disease prevention is very important for future well-designed clinical trials.Regarding dietary polyphenol intake, several studies have been identified in the recent literature reporting the daily intake of various classes and specific compounds in different regions of the world. [53][54][55][56][57][58][59][60][61] The results for individual countries are summarized in Table 1. Reported mean daily intake of total polyphenols ranges between 664 mg and 1756 mg.…”

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confidence: 99%

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Hydroxycinnamic acids and human health: recent advances

2019

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There is an urgent need to improve human diet globally. Compelling evidence gathered over the past several decades suggests that a suboptimal diet is associated with many chronic diseases and may be responsible for more deaths than any other risks worldwide. The main components in our diet that need higher intake are whole grains, fruit and vegetables, and nuts and seeds; all of these are important sources of dietary fiber and polyphenols. The health benefits of dietary fiber and polyphenols are also supported by several decades of valuable research. However, the conclusions drawn from interventional human trials are not straightforward and the action mechanisms in improving human health are not fully understood. Moreover, there is a great inter‐individual variation caused by different individual capabilities of processing, absorbing and using these compounds effectively. Data on the bioavailability and bioefficacy of hydroxycinnamic acids (HCAs) are limited when compared to other classes of polyphenols (e.g. anthocyanins). This review aims to summarize the latest research advances related to HCA bioavailability and their biological effects revealed by epidemiological data, pre‐clinical and clinical studies. Moreover, we aim to review the effects of HCAs on gut microbiota diversity and function and its respective influence on host health. © 2019 Society of Chemical Industry

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Section: Dietary Intake Of Hydroxycinnamic Acids and Associated Healtmentioning

confidence: 65%

Section: Dietary Intake Of Hydroxycinnamic Acids and Associated Healtmentioning

confidence: 73%

Section: Dietary Intake Of Hydroxycinnamic Acids and Associated Healtmentioning

confidence: 90%

Section: Dietary Intake Of Hydroxycinnamic Acids and Associated Healtmentioning

confidence: 99%

mentioning

confidence: 99%

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Hydroxycinnamic acids and human health: recent advances

2019

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Topoisomerase poisoning by the flavonoid nevadensin triggers DNA damage and apoptosis in human colon carcinoma HT29 cells

et al. 2021

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Nevadensin, an abundant polyphenol of basil, is reported to reduce alkenylbenzene DNA adduct formation. Furthermore, it has a wide spectrum of further pharmacological properties. The presented study focuses the impact of nevadensin on topoisomerases (TOPO) in vitro. Considering the DNA-intercalating properties of flavonoids, first, minor groove binding properties (IC50 = 31.63 µM), as well as DNA intercalation (IC50 = 296.91 µM) of nevadensin, was found. To determine potential in vitro effects on TOPO I and TOPO IIα, the relaxation and decatenation assay was performed in a concentration range of 1–500 µM nevadensin. A partial inhibition was detected for TOPO I at concentrations ≥ 100 µM, whereas TOPO IIα activity is only inhibited at concentrations ≥ 250 µM. To clarify the mode of action, the isolating in vivo complex of enzyme assay was carried out using human colon carcinoma HT29 cells. After 1 h of incubation, the amount of TOPO I linked to DNA was significantly increased by nevadensin (500 µM), why nevadensin was characterized as TOPO I poison. However, no effects on TOPO IIα were detected in the cellular test system. As a subsequent cellular response to TOPO I poisoning, a highly significant increase of DNA damage after 2 h and a decrease of cell viability after 48 h at the same concentration range were found. Furthermore, after 24 h of incubation a G2/M arrest was observed at concentrations ≥ 100 µM by flow cytometry. The analysis of cell death revealed that nevadensin induces the intrinsic apoptotic pathway via activation of caspase-9 and caspase-3. The results suggest that cell cycle disruption and apoptotic events play key roles in the cellular response to TOPO I poisoning caused by nevadensin in HT29 cells.

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Polyphenol intake and metabolic syndrome risk in European adolescents: the HELENA study

et al. 2019

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Purpose The role of polyphenol intake during adolescence to prevent metabolic syndrome (MetS) is little explored. This study aimed to evaluate the association between intake of total polyphenols, polyphenol classes and the 10 most consumed individual polyphenols with MetS risk in European adolescents. Methods Of the cross-sectional HELENA study, 657 adolescents (54% girls; 14.8% overweight; 12.5-17.5y) had a fasting blood sample and polyphenol intake data from two non-consecutive 24-hour recalls matched with the Phenol-Explorer database. MetS was defined via the pediatric American Heart Association definition. Multilevel linear regressions examined the associations of polyphenol quartiles with MetS components, while logistic regression examined the associations with MetS risk. Results After adjusting for all potential confounders (socio-demographics and 9 nutrients), total polyphenol intake, polyphenol classes and individual polyphenols were not associated with MetS risk. From all MetS components, only BMI z-score was modestly inversely associated with total polyphenol intake. Further sub analyses on polyphenol classes revealed that flavonoid intake was significantly associated with higher diastolic blood pressure and lower BMI, and phenolic acid intake was associated with higher low-density cholesterol. For individual polyphenols, the above BMI findings were often confirmed (not independent from dietary intake)and a few associations were found with insulin resistance. Conclusion Higher intakes of total polyphenols and flavonoids were inversely associated with BMI. No consistent associations were found for other MetS components.

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Estimated dietary intake of polyphenols in European adolescents: the HELENA study

Cited by 42 publications

References 48 publications

Hydroxycinnamic acids and human health: recent advances

Hydroxycinnamic acids and human health: recent advances

Topoisomerase poisoning by the flavonoid nevadensin triggers DNA damage and apoptosis in human colon carcinoma HT29 cells

Polyphenol intake and metabolic syndrome risk in European adolescents: the HELENA study

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