Background: An accurate estimated date of delivery (EDD) helps pregnant women make adequate preparations before delivery and avoid the panic of parturition. EDD is normally derived from some formulates or estimated by doctors based on last menstruation period and ultrasound examinations. The main aim of this study was to develop a hybrid model to improve the accuracy of EDD and promote the health and safety of pregnant women and fetuses. Methods: This study attempted to combine antenatal examinations and electronic medical records to develop a hybrid model based on Gradient Boosting Decision Tree and Gated Recurrent Unit (GBDT-GRU). Besides exploring the features that affect the EDD, GBDT-GRU model obtained the results by dynamic prediction of different stages. The mean square error (MSE), mean absolute error (MAE) and coefficient of determination (R2) were used to compare the performance among the different prediction methods. In addition, we evaluated predictive performances of different prediction models by comparing the proportion of pregnant women under the error of different days. Results: The clinical data were collected with 33,222 pregnancy examination records from 5537 Chinese pregnant women who have given birth. Experimental results showed that the hybrid GBDT-GRU model outperformed other prediction methods with coefficient of determination (R2) of 0.84, mean square error (MSE) of 41.73. We also found that the GBDT-GRU model had a smaller deviation by comparing the bias between the actual delivery date and the EDD under different methods. Conclusions: In comparison with other prediction methods, the GBDT-GRU model provided better performance results. The results of this study are helpful for the development of guidelines for clinical delivery treatments, as it can assist clinicians in making correct decisions during obstetric examinations.