Estimated contribution of hemoglobin and myoglobin to near infrared spectroscopy

Davis, Michelle L.; Barstow, Thomas J.

doi:10.1016/j.resp.2013.01.012

Cited by 106 publications

(111 citation statements)

References 73 publications

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“…Furthermore, the dynamic response of capillary hematocrit to contraction has not been studied in large mammals. Indirect evidence suggests that changes of capillary hematocrit observed in rats are similar to those measured in humans using near-infrared spectroscopy (6). Vasodilation and capillary recruitment are other factors that may affect both PS and Q in contracting muscle in vivo (21,35,36,46); however, it is expected that these factors are minimal for this canine muscle preparation.…”

Section: Discussionmentioning

confidence: 74%

Distinguishing the effects of convective and diffusive O₂ delivery on V̇o₂ on-kinetics in skeletal muscle contracting at moderate intensity

Spires

Gladden

Grassi

et al. 2013

American Journal of Physiology-Regulatory, Integrative and Comp

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With current techniques, experimental measurements alone cannot characterize the effects of oxygen blood-tissue diffusion on muscle oxygen uptake (Vo₂) kinetics in contracting skeletal muscle. To complement experimental studies, a computational model is used to quantitatively distinguish the contributions of convective oxygen delivery, diffusion into cells, and oxygen utilization to Vo₂ kinetics. The model is validated using previously published experimental Vo₂ kinetics in response to slowed blood flow (Q) on-kinetics in canine muscle (τQ = 20 s, 46 s, and 64 s) [Goodwin ML, Hernández A, Lai N, Cabrera ME, Gladden LB. J Appl Physiol. 112:9-19, 2012]. Distinctive effects of permeability-surface area or diffusive conductance (PS) and Q on Vo₂ kinetics are investigated. Model simulations quantify the relationship between PS and Q, as well as the effects of diffusion associated with PS and Q dynamics on the mean response time of Vo₂. The model indicates that PS and Q are linearly related and that PS increases more with Q when convective delivery is limited by slower Q dynamics. Simulations predict that neither oxygen convective nor diffusive delivery are limiting Vo₂ kinetics in the isolated canine gastrocnemius preparation under normal spontaneous conditions during transitions from rest to moderate (submaximal) energy demand, although both operate close to the tipping point.

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Section: Discussionmentioning

confidence: 74%

Distinguishing the effects of convective and diffusive O₂ delivery on V̇o₂ on-kinetics in skeletal muscle contracting at moderate intensity

Spires

Gladden

Grassi

et al. 2013

American Journal of Physiology-Regulatory, Integrative and Comp

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“…RSS is residual sum of squared errors for Gompertz (RSS G ), logistic (RSS L ), and exponential (RSS E ) functions * Significantly different from both RSS L and RSS E represents increased microvascular hematocrit (Boushel et al 2001;Kindig et al 2002;Klitzman and Duling 1979 Tran et al (1999) demonstrated that during cuff ischemia of the lower leg, Mb desaturation by NMR reached a maximum value by *4.5 min. Given that Mb content of human skeletal muscle is greater than previously thought (Marcinek et al 2007;Davis 2009), the dynamics of Mb de/resaturation may contribute significantly to the overall kinetics of the NIRS responses during PORH. Consistent with this, the observed time to the inflection point (X 0 ) for deoxy [Hb?Mb] in the present study (16.9 s) is similar to the time constants for Mb resaturation reported by Duteil et al (2004).…”

Section: Resultsmentioning

confidence: 92%

Characterizing near-infrared spectroscopy responses to forearm post-occlusive reactive hyperemia in healthy subjects

2011

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During post-occlusive reactive hyperemia (PORH) there is a temporary increase in the total hemoglobin + myoglobin (T[Hb+Mb]) signal as measured by near-infrared spectroscopy (NIRS). This transient increase predicts differences in the kinetic responses of deoxy[Hb+Mb] and oxy[Hb+Mb] during PORH. The purpose of this study was to determine whether sigmoidal (Gompertz or logistic) or exponential functions better describe these response curves during PORH. The fit of the three functions (exponential, Gompertz and logistic) to the NIRS responses, as determined from residual sum of squares, was compared using repeated measures ANOVA on Ranks. The Gompertz function provided a better fit to the oxy[Hb+Mb] response curve than did either the exponential or logistic function (χ (2) = 21.7, df = 2, p < 0.001). The logistic function provided a better fit for the deoxy[Hb+Mb] response (χ (2) = 22.9, df = 2, p < 0.001) than did either the Gompertz or exponential functions. For both NIRS signals, the better fitting sigmoidal functions fit the data well, with an average r value of 0.99 or greater. Adipose tissue thickness was correlated with parameters related to signal strength (amplitude, r = 0.86-0.89; baseline, r = 0.67-0.75; all p < 0.001) but was not related to kinetic parameters (time constant and inflection point; p > 0.05 for all comparisons). These results suggest that during PORH distinct sigmoidal mathematical functions best describe the responses of the oxy[Hb+Mb] (Gompertz) and deoxy[Hb+Mb] (logistic) as measured by NIRS. Further, differences in both the kinetic and amplitude aspects for the responses of oxy[Hb+Mb] and deoxy[Hb+Mb] predict the observed transient change in T[Hb+Mb]. Our methods provide a technique to evaluate and quantify NIRS responses during PORH, which may have clinical utility.

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“…It should be considered that ∆deoxy[Hb + Mb] reflects the balance between V O 2M and Q O 2M (i.e., V O 2M /QO 2M ratio) and thus microvascular O 2 extraction [i.e., proportional to C(a−v)O 2 ] (Boone et al 2014;DeLorey et al 2003;Ferreira et al 2006;Grassi et al 2003;Koga et al 2007) and ∆total[Hb + Mb] reflects the increase in microcirculation hematocrit (Hct) during (Boone et al 2014;Davis and Barstow 2013;Poole et al 2013).…”

Section: Discussionmentioning

confidence: 99%

“…∆deoxy[Hb + Mb] represents variations in the V O 2M /QO 2M ratio in the capillaries, reflecting the change in O 2 extraction [i.e., proportional to C(a−v)O 2 ] in the muscle (DeLorey et al 2003;Grassi et al 2003). Total[Hb + Mb] is a measurement of (oxy[Hb + Mb] + deoxy[Hb + Mb]) and its changes are suggested to represent variations in hematocrit of the microcirculation during exercise (Boone et al 2014;Davis and Barstow 2013).…”

Section: Muscle Oxygenationmentioning

confidence: 99%

Effect of pedaling cadence on muscle oxygenation during high-intensity cycling until exhaustion: a comparison between untrained subjects and triathletes

et al. 2015

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Estimated contribution of hemoglobin and myoglobin to near infrared spectroscopy

Cited by 106 publications

References 73 publications

Distinguishing the effects of convective and diffusive O₂ delivery on V̇o₂ on-kinetics in skeletal muscle contracting at moderate intensity

Distinguishing the effects of convective and diffusive O₂ delivery on V̇o₂ on-kinetics in skeletal muscle contracting at moderate intensity

Characterizing near-infrared spectroscopy responses to forearm post-occlusive reactive hyperemia in healthy subjects

Effect of pedaling cadence on muscle oxygenation during high-intensity cycling until exhaustion: a comparison between untrained subjects and triathletes

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Estimated contribution of hemoglobin and myoglobin to near infrared spectroscopy

Cited by 106 publications

References 73 publications

Distinguishing the effects of convective and diffusive O2 delivery on V̇o2 on-kinetics in skeletal muscle contracting at moderate intensity

Distinguishing the effects of convective and diffusive O2 delivery on V̇o2 on-kinetics in skeletal muscle contracting at moderate intensity

Characterizing near-infrared spectroscopy responses to forearm post-occlusive reactive hyperemia in healthy subjects

Effect of pedaling cadence on muscle oxygenation during high-intensity cycling until exhaustion: a comparison between untrained subjects and triathletes

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Distinguishing the effects of convective and diffusive O₂ delivery on V̇o₂ on-kinetics in skeletal muscle contracting at moderate intensity

Distinguishing the effects of convective and diffusive O₂ delivery on V̇o₂ on-kinetics in skeletal muscle contracting at moderate intensity