Estimate of Radiobiologic Parameters From Clinical Data for Biologically Based Treatment Planning for Liver Irradiation

Tai, A.; Erickson, Beth; Khater, K; Li, X. Allen

doi:10.1016/j.ijrobp.2007.10.037

Cited by 61 publications

(44 citation statements)

References 33 publications

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“…Second, the effective number of clonogens is extremely lower than figures obtained in EBRT. Third, the obtained α′ tumour values are also extremely low, 3 to 5 times lower than those obtained from EBRT (α= 0.01/Gy [29]), and close to the values of parenchyma obtained by our group from parenchyma volume reduction. These three observations show that in glass microsphere irradiation effective values of radiobiological parameters are different from those from EBRT.…”

Section: Dose-response Correlationsupporting

confidence: 82%

“…Radiobiological parameters from EBRT seemed to provide higher AUC values. On the contrary, the TCP fit gave in all cases a radiosensitivity from 0.002/Gy to 0.006/Gy, lower and definitely incompatible with the EBRT value (α=0.01±0.001/ Gy [29]). As a test, we drew a TCP curve using α=0.01/Gy and this laid indeed too much to the left of our experimental data, with a much lower TCP50 (Fig.…”

Section: Choice Of Radiobiological Parameters: Heavy Implication On Rmentioning

confidence: 71%

“…Using the relationships BED=D [1+d/(α/β)] and SF= exp(−α BED) with α/β=2.0 Gy, d=1.5 Gy, D=41.62 Gy, and identifying the cellular survival fraction with the FSU surviving fraction (SF=1/2), we have α parenchyma =0.0095/Gy. For lesions, Tai et al [29] obtained from tumour control probability (TCP) analysis a mean value α tumour =0.01±0.001/Gy. The two sets of radiobiological parameters are reported in Table 2.…”

Section: Two Sets Of Radiobiological Parametersmentioning

confidence: 99%

See 2 more Smart Citations

Radioembolization of hepatocarcinoma with 90Y glass microspheres: development of an individualized treatment planning strategy based on dosimetry and radiobiology

Chiesa

Mira

Maccauro

et al. 2015

Eur J Nucl Med Mol Imaging

146

183

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show abstract

Section: Dose-response Correlationsupporting

confidence: 82%

Section: Choice Of Radiobiological Parameters: Heavy Implication On Rmentioning

confidence: 71%

Section: Two Sets Of Radiobiological Parametersmentioning

confidence: 99%

See 1 more Smart Citation

Radioembolization of hepatocarcinoma with 90Y glass microspheres: development of an individualized treatment planning strategy based on dosimetry and radiobiology

Chiesa

Mira

Maccauro

et al. 2015

Eur J Nucl Med Mol Imaging

146

183

View full text Add to dashboard Cite

show abstract

“…It was suggested (15) that the normalized total dose (NTD) calculated by the linear-quadratic (LQ) model might be used to link the NTCP data from two fractionation schemes. However, this approach fails for Child-Pugh A liver patients when the dose per fraction of two fractionation schemes differs significantly (16).…”

Section: Introductionmentioning

confidence: 99%

Extrapolation of Normal Tissue Complication Probability for Different Fractionations in Liver Irradiation

Tai

Erickson

2009

International Journal of Radiation Oncology*Biology*Physics

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“…d/(a/b)], we calculate that the a/b value of normal hepatocytes is between 1 and 2 Gy, which corresponds to a BED of 126-108 Gy; however, the a/b value of HCC cells is between 12 and 16 Gy, which corresponds to a BED of only 66-69. 4 Gy. This suggests that hypofractionated RT would result in the death of more healthy hepatocytes than HCC cells.…”

Section: Fractionated or Hypofractionated Dose Is Need To Weigh Thementioning

confidence: 99%

Radiation therapy for hepatocellular carcinoma: current status and perspectives from our experience

Jiang

Zeng

2009

Oncol Rev

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Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide and is accompanied by a poor prognosis. We had reported that radiation therapy has great potential, in a wide spectrum of primary liver cancers, from local advanced stage of the disease to the more advanced stages, with regional nodal metastases, tumor thrombosis, and for palliation of distant metastases. Following the initial observation that HCC is radiosensitive and with the development of radiation technology, radiotherapy has become a feasible and promising treatment modality for HCC, particularly for advanced forms of the disease. Here, we review the substantial amount of available data on radiotherapy for HCC, report on the current status of this application of radiotherapy, and propose future avenues of research. Current status Hepatocellular carcinoma (HCC) is radiation-sensitiveThis conclusion is based primarily on the results of experimental study and clinical observation. Experimental resultsIn radiation biology, we determined that the a/b ratio of HCC is 11.2 Gy. This is equivalent to the value of poorly differentiated squamous cell carcinoma, with the survival curves of clonogenic cell assay applying the linear-quadratic (L-Q) model [1]. Clinical observationIt has been possible to deliver 70 Gy or higher doses directly to the HCC tumor with the availability of threedimensional conformal radiation therapy (3DCRT). It has been reported that a dose of 70 Gy results in complete remission of an intrahepatic tumor of more than 10 cm in diameter. As we had observed in the clinic, the objective response rate was 76% for a dose range of 50-60 Gy [2]. In patients with lymph node (LN) metastases of HCC, partial or complete responses were observed in 90% of those treated with 54 Gy and when the radiation dose was increased to 60 Gy, complete remission of the LN metastases was observed [3]. Tai et al. [4] estimated an a/b value of 15 ± 2 Gy, based on clinical data and using the Lyman model, which is consistent with the results of our clonogenic assay. These findings suggest that the radiosensitivity of HCC is similar to that of a poorly differentiated squamous cell carcinoma, such as nasopharyngeal carcinoma.Radiotherapy is effective for different stages of HCC, although higher level evidence-based medicine (EBM) is lackingTranscatheter arterial chemoembolization (TACE) combined with radiotherapy constitutes an improved therapeutic strategy for unresectable but confined intrahepatic HCC Transcatheter arterial chemoembolization does not induce complete or massive necrosis of HCC tumors greater than

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Estimate of Radiobiologic Parameters From Clinical Data for Biologically Based Treatment Planning for Liver Irradiation

Cited by 61 publications

References 33 publications

Radioembolization of hepatocarcinoma with 90Y glass microspheres: development of an individualized treatment planning strategy based on dosimetry and radiobiology

Radioembolization of hepatocarcinoma with 90Y glass microspheres: development of an individualized treatment planning strategy based on dosimetry and radiobiology

Extrapolation of Normal Tissue Complication Probability for Different Fractionations in Liver Irradiation

Radiation therapy for hepatocellular carcinoma: current status and perspectives from our experience

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