Estimate of dietary intake of chloropropanols (3-MCPD and 1,3-DCP) and health risk assessment

Arisseto, Adriana Pavesi; Vicente, Eduardo; Furlani, Régina Prado Zanes; Toledo, Maria Cecília de Figueiredo

doi:10.1590/s0101-20612013000500019

Cited by 23 publications

(10 citation statements)

References 9 publications

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“…Although the levels of exposure to food contaminated by 3-MCPD is not high for the general population, the growing consumption of some foods, such as frozen meals, which have higher levels of the contaminant, raise a concern (Arisseto, Vicente, Furlani, & Toledo, 2013). Furthermore, the presence of this compound in infant formulas and breast milk (Zelinková et al, 2008, Wöhrlin, Fry, Lahrssen-Wiederholt, & Preiß-Weigert, 2015) also indicates the need for further toxicological research in this area.…”

Section: Resultsmentioning

confidence: 99%

<b>Experimental exposure to 3-monochloropropane-1,2-diol from the pre-puberty causes damage in sperm production and motility in adulthood

Vieira¹,

Favareto²

2017

Acta Sci. Biol. Sci.

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Monochloropropane-1,2-diol (3-MCPD) is a food contaminant that can be formed during the thermic processing of various foodstuffs. Studies of reproductive toxicology of 3-MCPD are mainly concentrated in the evaluation of possible insults caused by exposure of adult animals. However, the prepuberty might be a period of different susceptibility to chemicals. The aim of this study was to evaluate the effects on reproductive endpoints of the 3-MCPD-exposure prepubertal male rats. Wistar male rats were assigned to 4 groups: control and exposed to 2.5; 5 or 10 mg kg-1 day-1 of 3-MCPD for 30 days by gavage. Testis and epididymis were used for sperm counts and histology analysis. Sertoli cell number and dynamic of the spermatogenesis were evaluated. Sperm were collected from the vas deferens for evaluation of the sperm motility and morphology. Number of sperm with progressive movement, number of Sertoli cells and germ cells and relative daily sperm production were decreased in the groups exposed to 5 and 10 mg kg-1 day-1 of 3-MCPD. Sperm morphology, testicular and epididymal histology were comparable among groups. Results show that 3-MCPD-exposure of rats from prepuberty might cause alterations in spermatogenesis and sperm maturation, similarly to exposure in adulthood.

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Section: Resultsmentioning

confidence: 99%

<b>Experimental exposure to 3-monochloropropane-1,2-diol from the pre-puberty causes damage in sperm production and motility in adulthood

Vieira¹,

Favareto²

2017

Acta Sci. Biol. Sci.

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“…Related to this, EFSA recently requested (unpublished) specific food preparation studies to investigate the potential for sucralose to result in the formation of specific PCDDs and PCDFs and 3-MCPD. It should be noted that these substances are found commonly in a wide range of foods, [14][15][16][17][18] however, some animal and cellular research has indicated potential carcinogenicity and, for this reason, some countries have set upper limits for the presence of certain of these substances in certain foods. 19,20 That said, the public health risk is considered to be low, 14 and human studies do not provide evidence of a safety risk from exposure to these substances with usual food intake.…”

Section: Introductionmentioning

confidence: 99%

Use of sucralose in foods heated during manufacturing does not pose a risk to human health

Gujral¹,

Carr²,

Tonucci³

et al. 2021

Toxicology Research and Application

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Regulatory agencies around the world have found sucralose to be a safe ingredient for use in food. A recent review by the German Federal Institute for Risk Assessment (BfR) hypothesized that sucralose use in foods heated during their manufacture might pose a health risk, by resulting in the formation of certain chlorinated compounds; specifically, polychlorinated dibenzodioxins (PCDDs), polychlorinateddibenzofurans (PCDFs) and/or free or bound 3-monochloropropanediol (3-MCPD), some of which are considered potential carcinogens. The BfR further encouraged the European Food Safety Authority (EFSA), which is in the process of conducting a staged re-evaluation of a range of food additives, including sucralose, to specifically address their hypothesis. This paper reports the results of new studies requested by EFSA to analyze for the presence of PCDDs, PCDFs and 3-MCPDs in a range of foods. As requested, foods were prepared with typical sucralose use levels and thermally processed under typical food processing conditions. The presence of the compounds of interest were analyzed using validated and accepted analytical methods (e.g. US Environmental Protection Agency (EPA); American Oil Chemists Society (AOCS)). The results of these new analytical studies show no evidence for the formation of these compounds due to sucralose presence. This paper also reports a critical analysis of the studies cited in the BfR review as the basis for its hypothesis. This analysis shows that the cited studies do not represent food manufacturing conditions and are thus not reliable for predicting the fate of sucralose in foods. This work reaffirms that sucralose is safe for use in food manufacture, including when heating is required.

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“…Chloropropanols including genotoxics and carcinogenics were found in processed foods and food ingredients. In Brazil Arisseto et al, (2013) evaluated dietary exposure to 3-MCPD and 1, 3-DCP and checked whether the existence of these substances in foods may present health risks.…”

Section: Introductionmentioning

confidence: 99%

Assessment of 3-Monochloro 1, 2-Propanediol in some Egyptian Foods and Its Impact on Liver and Renal Toxicity in Rats تقدیر 3- أحادى کلور بروبان 2،1 داى ول فى بعض الاغذیة المصریة وتأثیرة على سمیة الکبد والکلى فى الجرذان

Kandeel

El-Rahman

Elsanhoty

et al. 2020

Journal of Agricultural Chemistry and Biotechnology

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This study reports the results of the survey study on 3-monochloro1,2-propanediol (3-MCPD) levels in selected foods, oils and fats collected from supermarkets and restaurants in Egypt. Also; study the effect of feeding of rat on diet contained palm oil rich 3-MCPD on the biochemical parameters of rats. Twenty samples were collected from different supermarkets and restaurants in Egypt to determine 3-MCPD by GC-MS. The oil samples remained after from falafel frying showed the highest contents of 3-MCPD esters, with a mean value of 8.20 μg/kg oil, followed by palm oils and oils mixture. Forty Albino rats divided into five groups including one as a basal diet control. The other groups were fed on a a basal diet and replaced corn oil with crude palm oil heated at 200°C for 30min, heated palm oil at 200°C for 6h and palm oil fried with tortilla chips. Rats fed on either heated palm oil at 200°C for 6h and fried palm oil with tortilla chips showed elevated liver and kidney functions as well as lipid profile except HDLcholesterol and damages in some histological liver and kidney tissue compared with the control basal diet.This would risk forming esters of 3-MCPD fatty acids.

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Estimate of dietary intake of chloropropanols (3-MCPD and 1,3-DCP) and health risk assessment

Cited by 23 publications

References 9 publications

<b>Experimental exposure to 3-monochloropropane-1,2-diol from the pre-puberty causes damage in sperm production and motility in adulthood

<b>Experimental exposure to 3-monochloropropane-1,2-diol from the pre-puberty causes damage in sperm production and motility in adulthood

Use of sucralose in foods heated during manufacturing does not pose a risk to human health

Assessment of 3-Monochloro 1, 2-Propanediol in some Egyptian Foods and Its Impact on Liver and Renal Toxicity in Rats تقدیر 3- أحادى کلور بروبان 2،1 داى ول فى بعض الاغذیة المصریة وتأثیرة على سمیة الکبد والکلى فى الجرذان

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