Esthesioneuroblastoma: Is There a Need for Elective Neck Treatment?

Nodal metastasis and elective nodal level treatment in sinonasal small-cell and sinonasal undifferentiated carcinoma: a surveillance, epidemiology and end results analysis

“…This study cannot address whether there is inherent value in decreasing the risk of isolated nodal recurrence, as salvage may be feasible if a patient undergoes isolated recurrence in the unirradiated or undissected neck although the rates of salvage reported to date (50%) are not high, and in accordance with data for salvage of neck recurrence (4/7, 43%) in patients with paranasal esthesioneuroblastoma at the University of Michigan. 28 A disadvantage of this work is that observational studies such as the SEER suffer from bias from unmeasured confounding as a limitation. This includes information on how patients were staged.…”

Proton therapy for pediatric and adolescent esthesioneuroblastoma

“…Continued improvement in systemic control and reduced long term morbidity are required to improve disease control and quality of life in pediatric EN patients. (38) 54 (50) 53 (50) 38 (28) 43 ( 55 (43) 34 (20) 57 (16) 41 ( (24) 51 (37) 63 (54) 53 (12) 69 ( 32 (17) 37 (30) 46 (38) 37 (17) 51 ( 61 (57) 50 (47) 59 (34) 48 ( 55 (45) 56 (48) 55 (35) 57 ( 62 (57) 50 (46) 56 (30) 41 ( 52 (51) 53 (52) 51 (21) 48 ( …”

“…The risk of dissemination can be further stratified by reviewing the soft tissue compartments invaded (i.e., parapharyngeal space, retropharyngeal space, etc.) and the corresponding rate of lymphatic dissemination from the surgical literature both at presentation and the cumulative rate [35,37,38]. Additional consideration should be given to advanced Kadish stage as neck metastases can reach as high as 44% at presentation in contrast to Kadish A disease where lymph node risk may be <5% [35,37].…”

Olfactory neuroblastoma: A case report

“…Due to the high rate of regional failure following a lack of elective treatment on the neck, elective nodal RT is justified in patients with Kadish stage B and C disease. These results confirmed the beneficial effect of adjuvant RT to the tumor bed on local control (18). However, in a retrospective analysis, Montava et al (19) emphasized that the gold-standard treatment for ON is craniofacial resection and that mortality is associated with RT.…”