Esthesioneuroblastoma A Case Report

Chadha, Snya; Pannu, Kulwant Kaur

doi:10.1007/s12070-011-0186-x

Cited by 4 publications

(10 citation statements)

References 7 publications

(8 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…7,10 Differential diagnoses which need to be considered and ruled out on histology include neuroendocrine carcinoma, sinonasal undifferentiated carcinoma, rhabdomyosarcoma, melanoma, Ewing sarcoma, and lymphoma. 1,11 (Table 3)…”

Section: Resultsmentioning

confidence: 99%

Esthesioneuroblastoma: an institutional based descriptive study of a rare tumor

et al. 2023

View full text Add to dashboard Cite

Background: Esthesioneuroblastoma is a slow-growing rare malignant neuroectodermal tumor arising from the olfactory epithelium. It has a bimodal incidence with peaks in the second and third decades of life and the sixth and seventh decades of life with equal incidence among men and women. Prognostic factors include the Hyams grade and modified Kadish stage. This study analyzed the clinicopathological features of esthesioneuroblastoma. Materials and methods- Retrospective study of patients who were diagnosed with esthesioneuroblastoma at a tertiary care hospital between January 2012 and May 2019 was conducted. The research was performed according to the World Medical Association Declaration of Helsinki. Institutional research committee approval (IEC: 473/2019) was obtained. Results: Clinicopathological profiles of 8 patients who were diagnosed with esthesioneuroblastoma during the period were included. Among the eight patients, five were female and three were male. Common presenting complaints were nasal obstruction, difficulty in breathing, epistaxis, local pain, and anosmia. The average age of presentation was 52 years, ranging from 14 to 73 years. Anterior rhinoscopic examination in these cases showed a polypoid mass located in the nasal cavity. According to the Hyams grading system, three of the eight cases were grade-2 and the remaining five cases were grade-3 Hyams histological grade. Three cases exhibited foci of ganglioneuroblastic transformation. Three patients had metastases to cervical lymph nodes and three patients had recurrence. Conclusions: Esthesioneuroblastoma is a rare aggressive malignant tumor. It can exhibit divergent epithelial or ganglionic differentiation. A proper diagnosis should be made, graded and staged before proceeding to treatment.

show abstract

Section: Resultsmentioning

confidence: 99%

Esthesioneuroblastoma: an institutional based descriptive study of a rare tumor

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Esthesioneuroblastoma is staged by the Kadish system, this classification has a prognostic value and divides lesions into three stages: Stage A (tumor is limited to the nasal fossa); Stage B (tumor extends to the paranasal sinuses); and Stage C (tumor extends beyond the paranasal sinuses). The Dulguerov system uses the TNM classification and includes the imaging data, it considers the early invasion t of the cribriform plate in the T2 stage, and separates intracranial but extradural tumors from true brain involvement , [16] [17].…”

Section: Discussionmentioning

confidence: 99%

“…Craniofacial resection has become the best surgical procedure for achieving safe, en-bloc resection of the disease. Radiotherapy is systematically recommended, even after the resection of early stages of lesions with negative surgical margins 15 , 17 . Chemotherapy is reserved for unresectable or recurrent tumors as it was in our case, and for metastatic cases.…”

Section: Clinical Discussionmentioning

confidence: 99%

An atypical Esthesioneuroblastoma of the sphenoid sinus: a case report

Touihmi

Horrane

Rkain

2023

Annals of Medicine &Amp; Surgery

View full text Add to dashboard Cite

Introduction and importance: Esthesioneuroblastoma (ENB) is a rare tumor, arising from the olfactory epithelium. It manifests as an aggressive tumor in the superior aspect of the nasal cavity. Sinonasal symptoms are the most common. The cervical lymph nodes ensue in nearly 10% of cases and hematogenous metastases are rare. The diagnosis is histological. This tumor is staged using the Kadish et al System. The imaging techniques, using both computed tomography (CT) and MRI provides all the important information required for treatment modality. Today, the standard multimodal treatment combining external craniofacial resection, radiotherapy, and chemotherapy has improved long-term survival. Case presentation: A 27-year-old male patient with no medical history, complained of a headache, a unilateral right nasal obstruction, epistaxis, and anosmia for 2 months. Nasal endoscopy showed a pinkish-gray mass filling the right nasal cavity. An enhanced-contrast CT scan was performed and objectified a mildly enhancing extensive mass of the sphenoid sinus with bone erosion of the left wall of the sinus and intracranial involvement. An intranasal biopsy was performed, resulting in a histopathological diagnosis of olfactory neuroblastoma. Our case was staged as stage C according to the Kadish staging. The tumor was inoperable, the patient had chemotherapy, radiotherapy, and pain management. Clinical discussion: ENB is an aggressive malignant tumor derived from the specialized olfactory neuroepithelium of the upper nasal cavity. Several published reports confirm ectopic cases of ENB throughout the nasal cavity and the central nervous system. Because sinonasal malignant lesions are rare and difficult to distinguish from their benign counterparts. ENBs appears as a soft, glistening, polypoidal, or nodular mass covered by intact mucosa or as friable masses with ulceration and granulation tissue. A radiological, CT scan through the skull base and paranasal sinuses with intravenous contrast should be performed. ENBs are solid, enhancing nasal cavity masses that may manifest erosion into nearby osseous. MRI provides better discrimination between tumor and secretions and optimal assessment of orbital, intracranial, or brain parenchymal involvement. The biopsy is the next important step in securing a diagnosis. Classic treatment strategies of ENB are based on surgery or radiotherapy as unique modalities or a combination of surgery and radiation therapy. More recently, chemotherapy has been introduced in the therapeutic armamentarium since ENB has proven to be chemosensitive. The elective neck dissection remains controversial. Long-term follow-up is mandatory for patients with ENB. Conclusion: While most ENBs originate in the superior nasal vault and present with typical symptoms of nasal obstruction and epistaxis in the late stages of the disease, uncommon manifestations should be considered as well. Adjuvant therapy should be considered in patients with advanced disease and unresectable disease. A continuing follow-up period is needed.

show abstract

“…ENBs develop when these neuroblasts divide and grow in an uncontrolled manner [3]. ENBs account for 2-6% of all intranasal malignancies [4,5]. To put the rarity of ENB cases into perspective, there have been less than 700 cases documented in the United States and fewer than 400 unique cases reported globally.…”

Section: Introductionmentioning

confidence: 99%

“…To put the rarity of ENB cases into perspective, there have been less than 700 cases documented in the United States and fewer than 400 unique cases reported globally. ENB is equally prevalent between male and female patients between the ages of 40 and 60 [4]. Image Credit: Adapted by Frank Gaillard from the original illustration by Patrick J. Lynch, Creative Commons Attribution 2.5 License 2006 [3] Of note, there is a significant lack of depth of information on certain patient groups, populations, and risk factors associated with ENB [6,7].…”

Section: Introductionmentioning

confidence: 99%

Exploring the Impact of Artificial Intelligence and Machine Learning in the Diagnosis and Management of Esthesioneuroblastomas: A Comprehensive Review

Patel,

Masys,

Baridi

2024

Cureus

View full text Add to dashboard Cite

Esthesioneuroblastoma A Case Report

Cited by 4 publications

References 7 publications

Esthesioneuroblastoma: an institutional based descriptive study of a rare tumor

Esthesioneuroblastoma: an institutional based descriptive study of a rare tumor

An atypical Esthesioneuroblastoma of the sphenoid sinus: a case report

Exploring the Impact of Artificial Intelligence and Machine Learning in the Diagnosis and Management of Esthesioneuroblastomas: A Comprehensive Review

Contact Info

Product

Resources

About