Esterase D enhances type I interferon signal transduction to suppress foot-and-mouth disease virus replication

Li, Weiwei; Zhu, Zixiang; Cao, Weijun; Yang, Fan; Zhang, Xiangle; Li, Dan; Zhang, Keshan; Li, Pengfei; Mao, Ruoqing; Liu, Xiangtao; Zheng, Haixue

doi:10.1016/j.molimm.2016.05.016

Cited by 16 publications

(12 citation statements)

References 38 publications

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“…Carboxylesterases seem to be particularly sensitive to pollutants or radiation in insects, molluscs and rodents with responses that are very specific because they are not associated to a modulation of tissue protein content (Auda et al, 1987;Badiou-Bénéteau et al, 2012a;Carvalho et al, 2013a;Fleming et al, 2016;Franco et al, 2016). Such a sensitivity to environmental stressors is not surprising because these enzymes are involved in numerous metabolic processes, hormone metabolism, reproduction and development, neural development or cell signaling (Hosokawa et al, 2007;Jackson et al, 2013;Khalil et al, 2006;Li et al, 2016;Vose et al, 2008). Hence, the gamma rays could have effects on general metabolism, but other biomarkers could be more relevant to better understand their modes of action.…”

Section: Discussionmentioning

confidence: 99%

Physiological effects of gamma irradiation in the honeybee, Apis mellifera

Gagnaire

Bonnet²,

Tchamitchian³

et al. 2019

Ecotoxicology and Environmental Safety

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Terrestrial ecosystems are exposed to various kinds of pollutants, including radionuclides. The honeybee, Apis mellifera, is commonly used in ecotoxicology as a model species for evaluating the effects of pollutants. In the present study, honeybees were irradiated right after birth for 14 days with gamma rays at dose rates ranging between 4.38x10-3 and 588 mGy/d. Biological tissues (head, intestine and abdomen) were sampled at D3, D10 and D14. Ten different physiological markers involved in nervous (acetylcholinesterase (AChE)), antioxidative (catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione-S-transferase (GST)), immune system (phenoloxidase (PO)) and metabolism (carboxylesterases (CaEs) and alkaline phosphatase (ALP)) were measured. Univariate analyses were conducted to determine whether each individual biomarker response was positively or negatively correlated with the dose rate. Then, multivariate analyses were applied to investigate the relationships between all the biomarker responses. Although no mortality occurred during the experiment, several biomarkers varied significantly in relation to the dose rate. Globally, the biomarkers of antioxidant and immune systems decreased as the dose rate increased. Reversible effects on the indicator of the neural system were found. Concerning indicators of metabolism (carboxylesterases), variations occurred but no clear pattern was found. Taken altogether, these results help better understand the effects of ionizing radiation on bees by identifying relevant physiological markers of effects. These results could improve the assessment of the environmental risk due to ionizing radiation in terrestrial ecosystems.

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Section: Discussionmentioning

confidence: 99%

Physiological effects of gamma irradiation in the honeybee, Apis mellifera

Gagnaire

Bonnet²,

Tchamitchian³

et al. 2019

Ecotoxicology and Environmental Safety

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“…The viral infection experiment was carried out as previously described (Li et al, 2016b). Briefly, the cell cultures were washed with PBS for 3 times, and the virus was incubated for 1 h (h) in serum-free medium at the multiplicity of infection (MOI) of 0.5.…”

Section: Viral Infectionmentioning

confidence: 99%

“…Hepatitis C virus (HCV) internal ribosome entry site binds to PKR in competition with PKR ligands and prevents the phosphorylation and activation of PKR (Vyas et al, 2003). Our previous study found that FMDV infection leads to a significant decrease of PKR protein as infection progresses (Li et al, 2016b). It implies that PKR may suppress FMDV infection and the virus decreases PKR protein expression to block PKR activation and antagonize the antiviral response.…”

Section: Introductionmentioning

confidence: 99%

Foot-and-mouth disease virus induces lysosomal degradation of host protein kinase PKR by 3C proteinase to facilitate virus replication

Zhu

et al. 2017

Virology

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The interferon-induced double-strand RNA activated protein kinase (PKR) plays important roles in host defense against viral infection. Here we demonstrate the significant antiviral role of PKR against foot-and-mouth disease virus (FMDV) and report that FMDV infection inhibits PKR expression and activation in porcine kidney (PK-15) cells. The viral nonstructural protein 3C proteinase (3C) is identified to be responsible for this inhibition. However, it is independent of the well-known proteinase activity of 3C or 3C-induced shutoff of host protein synthesis. We show that 3C induces PKR degradation by lysosomal pathway and no interaction is determined between 3C and PKR. Together, our results indicate that PKR acts an important antiviral factor during FMDV infection, and FMDV has evolved a strategy to overcome PKR-mediated antiviral role by downregulation of PKR protein.

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“…In addition, the generated short Nterminal PKR fragment can be used by EV71 to enhance viral replication [84]. PKR was shown to be required for the antiviral activity in FMDV-infected porcine cells [85], and FMDV decreases PKR expression as infection progresses [86]. Further studies showed that FMDV 3C pro causes PKR degradation through activation of cellular lysosomal pathway [87].…”

Section: Evasion or Targeting Of Isgsmentioning

confidence: 99%

Innate immune evasion by picornaviruses

Zhang¹,

Paget

Wang³

et al. 2020

Eur J Immunol

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The family Picornaviridae comprises a large number of viruses that cause disease in broad spectrum of hosts, which have posed serious public health concerns worldwide and led to significant economic burden. A comprehensive understanding of the virus‐host interactions during picornavirus infections will help to prevent and cure these diseases. Upon picornavirus infection, host pathogen recognition receptors (PRRs) sense viral RNA to activate host innate immune responses. The activated PRRs initiate signal transduction through a series of adaptor proteins, which leads to activation of several kinases and transcription factors, and contributes to the consequent expression of interferons (IFNs), IFN‐inducible antiviral genes, as well as various inflammatory cytokines and chemokines. In contrast, to maintain viral replication and spread, picornaviruses have evolved several elegant strategies to block innate immune signaling and hinder host antiviral response. In this review, we will summarize the recent progress of how the members of family Picornaviridae counteract host immune response through evasion of PRRs detection, blocking activation of adaptor molecules and kinases, disrupting transcription factors, as well as counteraction of antiviral restriction factors. Such knowledge of immune evasion will help us better understand the pathogenesis of picornaviruses, and provide insights into developing antiviral strategies and improvement of vaccines.

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Esterase D enhances type I interferon signal transduction to suppress foot-and-mouth disease virus replication

Cited by 16 publications

References 38 publications

Physiological effects of gamma irradiation in the honeybee, Apis mellifera

Physiological effects of gamma irradiation in the honeybee, Apis mellifera

Foot-and-mouth disease virus induces lysosomal degradation of host protein kinase PKR by 3C proteinase to facilitate virus replication

Innate immune evasion by picornaviruses

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