Esterase‐Activatable and Glutathione‐Responsive Triptolide Nano‐Prodrug for the Eradication of Pancreatic Cancer

Sui, Binglin; Chen, Cheng; Shi, Shanshan; Wang, Mingming; Xu, Pao

doi:10.1002/anbr.202100040

Cited by 6 publications

(2 citation statements)

References 34 publications

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“…Chitosan oligosaccharide (CSO) conjugated triptolide could improve the water solubility to 15 mg/ml) ( Wang et al, 2022b ). Triptolide could also be conjugated with 2-(pyridin-2-yldisul-fanyl)ethyl acrylate (PDA)- poly (ethylene glycol) methyl (PEG) and lactobionic acid (LBA) ( Sui et al, 2021 ). Three amino acids (tryptophan, valine, and lysine) based triptolide prodrug could also inhibit the growth of pancreatic cancer ( Lou et al, 2021 ).…”

Section: Natural Products Undergoing Clinical Evaluation In Pancreati...mentioning

confidence: 99%

The therapeutic potential of natural products for treating pancreatic cancer

Wang

Zhang

et al. 2022

Front. Pharmacol.

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Pancreatic cancer is one of the most malignant tumors of the digestive tract, with the poor prognosis and low 5-year survival rate less than 10%. Although surgical resection and chemotherapy as gemcitabine (first-line treatment) has been applied to the pancreatic cancer patients, the overall survival rates of pancreatic cancer are quite low due to drug resistance. Therefore, it is of urgent need to develop alternative strategies for its treatment. In this review, we summarized the major herbal drugs and metabolites, including curcumin, triptolide, Panax Notoginseng Saponins and their metabolites etc. These compounds with antioxidant, anti-angiogenic and anti-metastatic activities can inhibit the progression and metastasis of pancreatic cancer. Expecting to provide comprehensive information of potential natural products, our review provides valuable information and strategies for pancreatic cancer treatment.

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Section: Natural Products Undergoing Clinical Evaluation In Pancreati...mentioning

confidence: 99%

The therapeutic potential of natural products for treating pancreatic cancer

Wang

Zhang

et al. 2022

Front. Pharmacol.

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“…WNT16B, a fibroblast hyperactivation signal, was found downregulated in comparison with chemotherapy, indicating its selectivity. Similarly, Saw et al developed an esterase-responsive polymer-prodrug for siRNA delivery, which allowed the nanoplatform to release its payload in tumor cells [100].…”

Section: Esterase-responsive Polymeric Nanomedicinementioning

confidence: 99%

Recent advances of bioresponsive polymeric nanomedicine for cancer therapy

et al. 2022

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A bioresponsive polymeric nanocarrier for drug delivery is able to alter its physical and physicochemical properties in response to a variety of biological signals and pathological changes, and can exert its therapeutic efficacy within a confined space. These nanosystems can optimize the biodistribution and subcellular location of therapeutics by exploiting the differences in biochemical properties between tumors and normal tissues. Moreover, bioresponsive polymer-based nanosystems could be rationally designed as precision therapeutic platforms by optimizing the combination of responsive elements and therapeutic components according to the patient-specific disease type and stage. In this review, recent advances in smart bioresponsive polymeric nanosystems for cancer chemotherapy and immunotherapy will be summarized. We mainly discuss three categories, including acidity-sensitive, redox-responsive, and enzyme-triggered polymeric nanosystems. The important issues regarding clinical translation such as reproducibility, manufacture, and probable toxicity, are also commented.

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