Establishment of the structural and enhanced physicochemical properties of the cocrystal-2-benzyl amino pyridine with oxalic acid

Sangeetha, M.; Mathammal, R.

doi:10.1016/j.molstruc.2017.04.085

Cited by 14 publications

(16 citation statements)

References 32 publications

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“…pyridine (HOMO -LUMO energy gap = 6.66eV), the resulting material had a significantly reduced energy gap 3.47eV (λ = 572nm) [37]. The same phenomenon was observed by Faizan et al [34] for another dicarboxilate salt: they observed that the HOMO-LUMO energy gap for the resulting salt was significantly lowered than its constituents; they concluded that this reduction may be due to the proton transfer process (N + −H…O − ) and…”

Section: Uv-visible Absorptionsupporting

confidence: 60%

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Cocrystallization through the use of a salt: The case of thiourea with a new propanediammonium oxalate salt

Kama

Jeanneau

Sidibe

et al. 2019

Journal of Crystal Growth

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A new blue photoluminescent 3D supramolecular salt namely 1, 3 propanediammonium oxalate has been synthesized and characterized by FT-IR spectroscopy and powder/single crystal X-ray diffraction. The incorporation of the environmental harmful thiourea was investigated. Single crystals were obtained after incorporation and the X-ray diffraction revealed the self-assembly of thiourea with 1, 3 propanediammonium oxalate. The thiourea interacts with the salt through strong hydrogen bonds. The intensity of the blue luminescence slightly decreases upon incorporation of thiourea.

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Section: Uv-visible Absorptionsupporting

confidence: 60%

“…This UV absorption may be assigned to π-π* and n-π* transition in oxalate ion. HOMO -LUMO energy gap of oxalic acid was already calculated in the literature to be 5.74eV (λ = 343nm) [37]. It was shown that after co-crystalization of oxalic acid with the 2-(benzylamino)…”

Section: Uv-visible Absorptionmentioning

confidence: 93%

Cocrystallization through the use of a salt: The case of thiourea with a new propanediammonium oxalate salt

Kama

Jeanneau

Sidibe

et al. 2019

Journal of Crystal Growth

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“…How to regulate and control the properties of substances in order to meet the needs of application in related fields is a hot topic of scientific research at present. Cocrystals, as a method that can effectively regulate the physical and chemical properties of substances, have been widely used in the preparation and processing of medicine, , food, , photoelectricity, , and MOF material , due to its effectiveness.…”

Section: Introductionmentioning

confidence: 99%

Thermodynamic and Crystallization of Lamotrigine Cocrystal

Kuang

Xu³

et al. 2019

Crystal Growth & Design

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Two novel lamotrigine cocrystals, namely, lamotrigine (LAM) phthalimide (PTL) cocrystal (1) and lamotrigine (LAM) succinimide (SUC) cocrystal monohydrate (1:1:1) (2), were successfully synthesized by liquid-assisted grinding and evaporative crystallization, and their structures were determined by XRD (power and single-crystal X-ray diffraction) and FT-IR. Ternary phase diagrams of LAM–PTL were constructed for the obtained cocrystal in isobutanol and ethyl propionate at two different temperatures, i.e., 298.15and 303.15 K. A narrow stability region was found for the pure LAM–PTL cocrystal in the phase diagram at both temperatures. The solubility of LAM–PTL was measured by suspending cocrystal in solutions of varying PTL concentrations in ethyl propionate and isobutanol. The mathematical model described by the solubility product of cocrystal components K sp and by solution complexation constants K 11 was used to fit the solubility of LAM–PTL cocrystal. It can be concluded that K sp values increase as the cocrystal solubility increases, while K 11 values decrease. Graphical representation of the cocrystal solubility dependence on ligand concentration will serve as a diagnostic tool for the stoichiometry of solution complexes. The results of the stability study demonstrated that 1 and 2 are stable under the conditions of both 85% and 98% RH at 25 °C.

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“…Moreover, the PXRD pattern of STH−PABA cocrystal was significantly different from those for the coformers and simple physical mixture, which was consistent with the previous studies, 4 and the results also revealed a new solid phase was generated with distinguishable characteristics at multiple positions. 7 Additionally, it was noticed that the STH− PABA cocrystal was able to be isolated by neat or solvent-drop cogrinding under 60 min in the previous report, 17 while the growth of pure STH−PABA cocrystal in the acetone solution required almost 3 days by spontaneous evaporation. The relatively slow rate of cocrystallization might be a result of the undersaturation and at the possibly low driving force of 1:1 component stoichiometric ratios; 9,24 yet the slow solution evaporation would promote the formation of high quality single crystals suitable for X-ray structure determination.…”

Section: ■ Introductionmentioning

confidence: 92%

Cocrystal of Sulfamethazine and p-Aminobenzoic Acid: Structural Establishment and Enhanced Antibacterial Properties

Pan

Zheng

Chen

et al. 2019

Crystal Growth & Design

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The engineering of pharmaceutical cocrystals has been effectively utilized to improve the physicochemical properties such as stability and solubility, and thus it could optimize the solid formations of active pharmaceutical ingredients. This work focuses on the sulfamethazine–p-aminobenzoic acid (STH–PABA) cocrystal regulated by molecular synthons constructed from mutual N···H···O interactions. The STH–PABA cocrystal was produced by means of the slow evaporation crystallization method, and the cocrystal structure was determined through X-ray crystallography. Meanwhile, X-ray diffraction, differential scanning calorimetry, thermogravimetric analysis, Fourier transform infrared spectroscopy, Raman, and NMR were applied to analyze the features of the STH–PABA cocrystal. Special attention was paid to in vitro antibacterial activity and microscopic investigations. Our findings indicated that the formation of cocrystals could enhance the solubility and slightly improve the release behavior of STH, and increase the leaking of bacterial cell inclusion that leads to enhanced antibacterial activity.

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Establishment of the structural and enhanced physicochemical properties of the cocrystal-2-benzyl amino pyridine with oxalic acid

Cited by 14 publications

References 32 publications

Cocrystallization through the use of a salt: The case of thiourea with a new propanediammonium oxalate salt

Cocrystallization through the use of a salt: The case of thiourea with a new propanediammonium oxalate salt

Thermodynamic and Crystallization of Lamotrigine Cocrystal

Cocrystal of Sulfamethazine and p-Aminobenzoic Acid: Structural Establishment and Enhanced Antibacterial Properties

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