Establishment of the hybrid endoscopic full-thickness resection of gastric gastrointestinal stromal tumors

Abstract

Abstract. A prospective observational study was conducted to establish the procedure of hybrid endoscopic full-thickness resection (EFTR) using an existing flexible endoscope. The present study included 16 patients who underwent hybrid EFTR between September 2009 and February 2013 for gastric gastrointestinal stromal tumor (GIST). The patients were selected using the following inclusion criteria for histological findings: Mitotic counts <5/high-power field and immunohistochemical stains positive for KIT or cluster of differentiation 34 (CD34). The mean patient age was 68.2 years (range, 44-81 years); the male-to-female ratio was 6:10; lesion sites at upper (U), middle (M) and lower regions (L) of the stomach were 9/6/1; and the average tumor diameter was 28.3 mm. The mean surgical time was 271 min and the surgical time became progressively faster with each successive surgery. There were 12 and four patients with mitotic counts of <5 and 5-10, respectively, which was significantly different (P= 0.01). Immunohistochemical stains showed that tumors from 13 and 10 patients (81.2 and 62.5%, respectively) were positive for KIT and CD34, respectively (P= 0.328). All resected surgical margins were negative. According to Fletcher's risk classification, there were five, eight and three patients at an 'extremely low ', 'low', and 'intermediate' risk (31.2, 50 and 18.8%, respectively) (P=0.003). The mean postoperative hospital duration was 12.3 days (range, 10-15 days).In conclusion, an ultra-minimally invasive surgery-hybrid EFTR is a safe and established surgical endoscopy procedure.

Endoscopic resection of gastric submucosal tumors: A comparison of endoscopic nontunneling with tunneling resection and a systematic review

“…As shown in Figure 3 , the search of the PubMed database yielded 8 (294 tumors), 5 (166 tumors), and 2 (51 tumors) studies on gastric submucosal tumors resected by endoscopic non-tunneling (ESD[ 6 7 8 12 13 14 15 16 ] and EFTR[ 9 10 17 18 19 ]) and tunneling resection,[ 11 20 ] respectively. Related information was extracted from each study (Supplemental data).…”

Endoscopic full-thickness resection for gastric gastrointestinal stromal tumor originating from the muscularis propria

“…Successful treatment using EFR required successful repair of the perforation, thus avoiding the need for additional surgical repair and postoperative peritonitis (8)(9)(10). The most common method for re- .…”

Serosal and muscular layers incision technique in laparoscopic surgery for gastric gastrointestinal stromal tumors

“…documented the use of non‐exposed endoscopic wall‐invasion surgery (NEWS) , and Mori et al . described hybrid endoscopic full‐thickness resection . These procedures can minimize the volume of resected stomach tissue and limit postoperative deformities of the stomach.…”

“…No artificial perforations are required for NEWS, and unexpected perforations rarely occur . Furthermore, perioral removal of tumor specimen limits the use of NEWS or endoscopic full‐thickness resection for larger tumors . Compared with these procedures, SAMIT is a simple procedure.…”