Establishment of resveratrol and its derivatives as neuroprotectant against monocrotophos-induced alteration in NIPBL and POU4F1 protein through molecular docking studies

Yadav, Ruchi; Srivastava, Prachi

doi:10.1007/s11356-019-06806-3

Cited by 5 publications

(1 citation statement)

References 53 publications

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“…POU4F1 (POU Class 4 Homeobox 1) is an important molecule in the POU TF family and is expressed in central neural precursor cells in the early stage of embryonic development ( 54 ). The TF POU4F1 can bind to the promoter region of the Bcl-2 gene to regulate its expression and interact with the P53 protein to regulate its transcriptional activity ( 55 ). Thus, the TF POU4F1 can promote the differentiation of the nervous system and inhibit the apoptosis of nerve cells.…”

Section: Discussionmentioning

confidence: 99%

lncRNA and circRNA expression profiles in the hippocampus of Aβ_25‑35‑induced AD mice treated with Tripterygium glycoside

Tang

Wang

et al. 2023

Exp Ther Med

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Tripterygium glycosides (TG) have been reported to ameliorate Alzheimer's disease (AD), although the mechanism involved remains to be determined. In the present study, the lncRNA and circRNA expression profiles of an AD mouse model treated with TG were assessed using microarrays. lncRNAs, mRNAs, and circRNAs in the hippocampi of 3 AD+normal saline (NS) mice and 3 AD+TG mice were detected using microarrays. The most differentially expressed lncRNAs, mRNAs, and circRNAs were screened between the AD+NS and AD+TG groups. The differentially expressed lncRNAs and circRNAs were analyzed using GO enrichment and KEGG analyses. Co-expression analysis of lncRNAs, circRNAs, and mRNAs was performed by calculating the correlation coefficients. Protein-protein interaction (PPI) network analysis was performed on mRNAs using STRING. The lncRNA-target-transcription factor (TF) network was analyzed using the Network software. In total, 661 lncRNAs, 64 circRNAs, and 503 mRNAs were found to be differentially expressed in AD mice treated with TG. Pou4f1, Egr2, Mag, and Nr4a1 were the hub genes in the PPI network. The KEGG results showed that the mRNAs that were co-expressed with lncRNAs were enriched in the TNF, PI3K-Akt, and Wnt signaling pathways. LncRNA-target-TF network analysis indicated that TFs, including Cebpa, Zic2, and Rxra, were the most likely to regulate the detected lncRNAs. The circRNA-miRNA interaction network indicated that 275 miRNAs may bind to the 64 circRNAs. In conclusion, these findings provide a novel perspective on AD pathogenesis, and the detected lncRNAs, mRNAs, and circRNAs may serve as novel therapeutic targets for the management of AD.

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Section: Discussionmentioning

confidence: 99%

lncRNA and circRNA expression profiles in the hippocampus of Aβ_25‑35‑induced AD mice treated with Tripterygium glycoside

Tang

Wang

et al. 2023

Exp Ther Med

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POU4F1 confers trastuzumab resistance in HER2-positive breast cancer through regulating ERK1/2 signaling pathway

Jia

Wei

et al. 2020

Biochemical and Biophysical Research Communications

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Resveratrol attenuates manganese-induced oxidative stress and neuroinflammation through SIRT1 signaling in mice

Liu

Lei

Liu

et al. 2021

Food and Chemical Toxicology

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Establishment of resveratrol and its derivatives as neuroprotectant against monocrotophos-induced alteration in NIPBL and POU4F1 protein through molecular docking studies

Cited by 5 publications

References 53 publications

lncRNA and circRNA expression profiles in the hippocampus of Aβ_25‑35‑induced AD mice treated with Tripterygium glycoside

lncRNA and circRNA expression profiles in the hippocampus of Aβ_25‑35‑induced AD mice treated with Tripterygium glycoside

POU4F1 confers trastuzumab resistance in HER2-positive breast cancer through regulating ERK1/2 signaling pathway

Resveratrol attenuates manganese-induced oxidative stress and neuroinflammation through SIRT1 signaling in mice

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Establishment of resveratrol and its derivatives as neuroprotectant against monocrotophos-induced alteration in NIPBL and POU4F1 protein through molecular docking studies

Cited by 5 publications

References 53 publications

lncRNA and circRNA expression profiles in the hippocampus of Aβ25‑35‑induced AD mice treated with Tripterygium glycoside

lncRNA and circRNA expression profiles in the hippocampus of Aβ25‑35‑induced AD mice treated with Tripterygium glycoside

POU4F1 confers trastuzumab resistance in HER2-positive breast cancer through regulating ERK1/2 signaling pathway

Resveratrol attenuates manganese-induced oxidative stress and neuroinflammation through SIRT1 signaling in mice

Contact Info

Product

Resources

About

lncRNA and circRNA expression profiles in the hippocampus of Aβ_25‑35‑induced AD mice treated with Tripterygium glycoside

lncRNA and circRNA expression profiles in the hippocampus of Aβ_25‑35‑induced AD mice treated with Tripterygium glycoside