Establishment of reference intervals for immunoassay analytes of adult population in Saudi Arabia

Borai, Anwar; Ichihara, Kiyoshi; Masaud, Abdulaziz Al; Tamimi, Waleed; Bahijri, Suhad; Armbuster, David; Kawano, Reo; Baarmah, Ziad; Joatar, Faris; Almohammadi, Mohammed

doi:10.1515/cclm-2019-1049

Cited by 16 publications

(20 citation statements)

References 17 publications

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“…The signi cance of each variable was evaluated as standard partial regression coe cient (r p ), which corresponded to partial correlation coe cient and takes value between −1.0 and 1.0. Based on an objective classi cation system in previous studies [15,16], the practical correlation was characterized as slight for 0.20≤|r p |<0.30, moderate for 0.30≤|r p |< 0.50 and strong for 0.50≥|r p |. All statistical analyses were performed using the R statistic software (version 3.6.0) and MedCalc Software (version 15.2).…”

Section: Discussionmentioning

confidence: 99%

Reference Intervals for 26 Common Biochemical Analytes in Term Neonates in Jilin Province, China

Wang

Zhu

Zhou

et al. 2020

Preprint

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Background: Biochemical analytes provide information for neonatal disease management and therapy, and population-based reference intervals (RIs) are essential to accurately interpret laboratory test results. This study aimed to establish local RIs for biochemical assays in term neonates.Methods: A total of 195 healthy term neonates from birth to 3rd day were recruited as reference individuals prospectively. Analytes of 26 common biochemistries were measured using the VITROS 5600 Integrated System. The 3-level nested ANOVA was performed to assess the need for partitioning RIs of each analytes, and RIs were derived by a nonparametric method or robust method. Multiple regression analysis was used to evaluate specific correlations between the analytes and individual characteristics including age, gender, gestational age, birthweight and delivery mode.Results: There were no between-sex differences in all analytes, whereas there were significant between-day-age differences in 6 analytes. Small between-delivery-mode differences were observed in the results for potassium, phosphate, and urea. The major related factor of most analytes was postnatal age. During the first 3 days, values of iron, lipids and lipoproteins increased; creatinine, urea, uric acid, creatine kinase and lactate dehydrogenase decreased; other analytes showed slight changes or relatively stable trends. Reference limits of some analytes, particularly lactate dehydrogenase and alkaline phosphatase, were significant different from adult and pediatric groups.Conclusions: RIs of 26 common biochemical analytes are established for term neonates aged 0 to 3 days in northeast China. Additionally, it is suggested that age-related changes should be valued in the clinical decision-making process for newborns.

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Section: Discussionmentioning

confidence: 99%

Reference Intervals for 26 Common Biochemical Analytes in Term Neonates in Jilin Province, China

Wang

Zhu

Zhou

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…The significance of each variable was evaluated as standard partial regression coefficient (r p ), which corresponded to partial correlation coefficient and takes value between − 1.0 and 1.0. Based on an objective classification system in previous studies [24,25], the practical correlation was characterized as slight for 0.20 ≤ |r p | < 0.30, moderate for 0.30 ≤ |r p | < 0.50 and strong for 0.50 ≥ |r p |. All statistical analyses were performed using the R statistic software (version 3.6.0) and MedCalc Software (version 15.2).…”

Section: Discussionmentioning

confidence: 99%

Reference intervals for 26 common biochemical analytes in term neonates in Jilin Province, China

et al. 2021

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Background Biochemical analytes provide information for neonatal disease management and therapy, and population-based reference intervals (RIs) are essential to accurately interpret laboratory test results. This study aimed to establish local RIs for biochemical assays in term neonates. Methods A total of 195 healthy term neonates from birth to 3rd day were recruited as reference individuals prospectively. Analytes of 26 common biochemistries were measured using the VITROS 5600 Integrated System. The 3-level nested ANOVA was performed to assess the need for partitioning RIs of each analyte, and RIs were derived by a nonparametric method or robust method. Multiple regression analysis was used to evaluate specific correlations between the analytes and individual characteristics including age, gender, gestational age, birthweight and delivery mode. Results There were no between-sex differences in all analytes, whereas there were significant between-day-age differences in 6 analytes. Small between-delivery-mode differences were observed in the results for potassium, phosphorus, and urea. The major related factor of most analytes was postnatal age. During the first 3 days, values of iron, lipids and lipoproteins increased; creatinine, urea, uric acid, creatine kinase and lactate dehydrogenase decreased; other analytes showed slight changes or relatively stable trends. Reference limits of some analytes, particularly lactate dehydrogenase and alkaline phosphatase, were significantly different from adult and pediatric groups. Conclusions RIs of 26 common biochemical analytes are established for term neonates aged 0 to 3 days in northeast China. Additionally, it is suggested that age-related changes should be valued in the clinical decision-making process for newborns.

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“…Since SD RI or the denominator of BR is composed of both SD I and SD G and equal to , we set 0.375 as a threshold for BR. This scheme was adopted in recent papers [ 8 , 9 ]. On the other hand, both SDR and BR depend on their common denominator, SD RI .…”

Section: Methodsmentioning

confidence: 99%

“…, we set 0.375 as a threshold for BR. This scheme was adopted in recent papers [8,9]. On the other hand, both SDR and BR depend on their common…”

Section: Plos Onementioning

confidence: 99%

Determination of reference intervals for common chemistry and immunoassay tests for Kenyan adults based on an internationally harmonized protocol and up-to-date statistical methods

et al. 2020

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Background Due to a lack of reliable reference intervals (RIs) for Kenya, we set out to determine RIs for 40 common chemistry and immunoassay tests as part of the IFCC global RI project. Methods Apparently healthy adults aged 18-65 years were recruited according to a harmonized protocol and samples analyzed using Beckman-Coulter analyzers. Value assigned serum panels were measured to standardize chemistry results. The need for partitioning reference values by sex and age was based on between-subgroup differences expressed as standard deviation ratio (SDR) or bias in lower or upper limits (LLs and ULs) of the RI. RIs were derived using a parametric method with/without latent abnormal value exclusion (LAVE). Results Sex-specific RIs were required for uric acid, creatinine, total bilirubin (TBil), total cholesterol (TC), ALT, AST, CK, GGT, transferrin, transferrin saturation (TfSat) and immunoglobulin-M. Age-specific RIs were required for glucose and triglyceride for both sexes, and for urea, magnesium, TC, HDL-cholesterol ratio, ALP, and ferritin for females. LAVE was effective in optimizing RIs for AST, ALT, GGT iron-markers and CRP by reducing influence of latent anemia and metabolic diseases. Thyroid profile RIs were derived after excluding volunteers with anti-thyroid antibodies. Kenyan RIs were comparable to those of other countries participating in the global study with a few exceptions such as higher ULs for TBil and CRP.

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Establishment of reference intervals for immunoassay analytes of adult population in Saudi Arabia

Abstract: AbstractBackgroundThis is a second part of report on the IFCC global multicenter study conducted in Saudi Arabia to derive reference intervals (RIs) for 20 immunoassay analytes including five tumor makers, five reproductive, seven other hormones and three vitamins.Methods… Show more

Cited by 16 publications

References 17 publications

Reference Intervals for 26 Common Biochemical Analytes in Term Neonates in Jilin Province, China

Reference Intervals for 26 Common Biochemical Analytes in Term Neonates in Jilin Province, China

Reference intervals for 26 common biochemical analytes in term neonates in Jilin Province, China

Determination of reference intervals for common chemistry and immunoassay tests for Kenyan adults based on an internationally harmonized protocol and up-to-date statistical methods

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