Establishment of reference intervals for complete blood count parameters during normal pregnancy in Beijing

Abstract

The changes of CBC parameters during pregnancy are described, and reference intervals for Beijing pregnant women are demonstrated in this study.

A Review of Hemostasis in Normal Pregnancy and Puerperium

“…Another possible mechanism is an increased consumption of platelets inside utero-placental circulation [7,8] accelerating thrombopoiesis in bone marrow. As a result, an increase in mean platelet volume (MPV), platelet distribution width and large-size platelets in peripheral film were observed in many [7,9,17,25] but not all reports [18,26]. Large-sized platelets may be pathogenic [27] but since platelet turnover is usually normal [20] and platelet count is low therefore, overall effect is a balanced platelet mass [7].…”

“…Sejeny in 1975 [6] was the first to report gestational thrombocytopenia in 405 healthy pregnant women using electronic particle counter [6]. Since then, a number of global reports described a sequential reduction of platelet count as pregnancy advances [7][8][9][10][11][12][13][14][15][16][17][18] with a 10-20% fall in platelet count [19]. Frequency of gestational thrombocytopenia was estimated to be 7-12% at term [12,14,15].…”

Red blood cell distribution width in pregnancy: a systematic review

“…After full-text review of the remaining 39 articles, eleven studies were excluded because they did not meet the inclusion criteria. Finally, 28 studies were included in the review ( 10 - 37 ). Among them, three articles reported RDW values in physiological pregnancy, seven articles focused on anaemia, seven on preeclampsia, and eleven articles on other complications such as cholestasis, diabetes, pancreatitis, and ectopic pregnancy.…”

“…This uncertainty remains in more recent studies. Li et al reported in a prospective study a temporal increase in RDW-CV reference intervals (2.5th and 97.5th percentile, confidence intervals, CI) in 3060 healthy pregnant Chinese women: 11.9% (11.8-11.9) - 16.8% (16.4-18.0), 12.3% (12.2-12.4) - 17.2% (16.5-18.5), and 12.3% (12.2-12.3) - 19.8% (19.3-20.5) in the first, second and third trimester, respectively ( 10 ). The median RDW values were significantly different between non-pregnant and pregnant women (12.3% versus 13.5%, respectively, P < 0.001).…”

Association between gestational age at delivery and lymphocyte-monocyte ratio in the routine second trimester complete blood cell count

“…Unlike these two studies, we prospectively collected maternal CBC parameters during routine 50-gram OGTT and enrolled our patients before they had developed threatened preterm labor. The differential count of CBC is known to change during normal pregnancy [6,17]. Li et al [6] established a reference interval for CBC parameters during normal pregnancy in Chinese women showing a decrease in lymphocyte count contrary to the changes in white blood cell count due to the increase in neutrophil count.…”