Establishment of CRISPR-Cas-based antiparasitic agents for the swimming crab parasite Mesanophrys sp.

Wang, Xiaopeng; Zhou, Yueyue; Zhang, Yingchao; Song, Xiaofen; Shi, Ce; Fu, Yuanyuan; Liu, Lei; Mu, Changkao; Yin, Fei; Song, Weiwei; Wang, Chunlin

doi:10.1016/j.aquaculture.2023.740228

Cited by 1 publication

(1 citation statement)

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“…Bacterial cells or viruses can be precisely engineered to exert therapeutic actions in the body (from treating infectious diseases to genetic diseases such as cancer; Chowdhury et al., 2019 ; Mazzolini et al., 2023 ) and, in this regard, the CRISPR‐Cas13 system could be employed as a tool for such genome engineering (e.g. phage engineering; Adler et al., 2022 ) or as a programmable genetic module to implement new regulations in those genomes (Wang et al., 2024 ). In agriculture, viral vectors carrying CRISPR systems could be instrumental to modify crop traits by regulating specific plant genes (Yu et al., 2020 ), with the aim of optimizing yields and resilience and ultimately contributing to global food security and sustainability.…”

Section: Discussionmentioning

confidence: 99%

On the ever‐growing functional versatility of the CRISPR‐Cas13 system

Montagud‐Martínez,

Márquez‐Costa,

Heras‐Hernández

et al. 2024

Microbial Biotechnology

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CRISPR‐Cas systems evolved in prokaryotes to implement a powerful antiviral immune response as a result of sequence‐specific targeting by ribonucleoproteins. One of such systems consists of an RNA‐guided RNA endonuclease, known as CRISPR‐Cas13. In very recent years, this system is being repurposed in different ways in order to decipher and engineer gene expression programmes. Here, we discuss the functional versatility of the CRISPR‐Cas13 system, which includes the ability for RNA silencing, RNA editing, RNA tracking, nucleic acid detection and translation regulation. This functional palette makes the CRISPR‐Cas13 system a relevant tool in the broad field of systems and synthetic biology.

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