Establishment of Community-Based Reference Intervals for Fructosamine, Glycated Albumin, and 1,5-Anhydroglucitol

Selvin, Elizabeth; Warren, Bethany; He, Xintong; Sacks, David B.; Saenger, Amy K.

doi:10.1373/clinchem.2017.285742

Cited by 64 publications

(62 citation statements)

References 33 publications

(26 reference statements)

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“…5,6 Many countries and regions established their own RIs for clinical use. 2,23,24 However, 1,5-AG is quite different among regions and ethnicities. 25,26 It is also influenced by diets 21 and other factors.…”

Section: Discussionmentioning

confidence: 98%

Reference intervals for serum 1,5‐anhydroglucitol of a population with normal glucose tolerance in Jiangsu Province

Chen

Wang

Tan

et al. 2020

Journal of Diabetes

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Background: Serum 1,5-anhydroglucitol (1,5-AG) is a new glycemic marker which can reflect glucose fluctuation over 3 to 7 days and is now increasingly used to monitor glucose control and to screen for diabetes. However, 1,5-AG has not been widely used in China due to lack of epidemiological support. Our study aims to establish the reference intervals for a population with normal glucose tolerance in Jiangsu Province and to explore the determinants of these intervals. Method:The study enrolled 646 healthy adults aged 20 to 70 years in Jiangsu Province in 2018 after oral glucose tolerance test. 1,5-AG, fasting and 2-hour glucose, UA, liver enzyme, serum lipid, creatinine, and glycosylated hemoglobin were measured. We calculated reference intervals using the parametric method and examined the relationship between 1,5-AG and influence factors.Results: The average age of the participants was 50.5 ± 9.0 years, and 69.5% of them were females. The reference intervals were 15.8 to 52.6 μg/mL for males and 14.3 to 48.0 μg/mL for females. Among females, the reference intervals were 13.9 to 45.3 and 14.6 to 49.6 μg/mL for menopausal and postmenopausal females, respectively. Males showed higher 1,5-AG concentrations than females, and postmenopausal females had higher 1,5-AG than menopausal females. There was a positive correlation between uric acid and 1,5-AG in both genders. Positive correlation between 1,5-AG and age was only observed in females. Conclusion:We established reference intervals for 1,5-AG in Jiangsu Province, and the level of 1,5-AG is affected by sex, uric acid, and age. Highlights• Males, menopausal females, and postmenopausal females had corresponding reference intervals for 1,5-anhydroglucitol (1,5-AG). • Levels of serum uric acid and age should be taken into consideration when interpreting 1,5-AG.

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Section: Discussionmentioning

confidence: 98%

Reference intervals for serum 1,5‐anhydroglucitol of a population with normal glucose tolerance in Jiangsu Province

Chen

Wang

Tan

et al. 2020

Journal of Diabetes

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“…HbA1c concentration was 54 mmol/mol and haemoglobin concentration 105 g/L. HbA1c of 48 mmol/mol or 6.5% approximately equates to fructosamine of 270.2 µmol/L 15. The relatively low HbA1c was related to low haemoglobin and rapid turnover of red blood cells owing to gastrointestinal blood loss and consequently accelerated erythropoiesis.…”

Section: Outcomementioning

confidence: 94%

“…15 NICE guideline NG28 recommends total glycated haemoglobin, fructosamine, and glucose profiling for monitoring when HbA1c is unreliable (fig1). 9 Currently, costs, inadequate assay standardisation, and lack of consensus about specific treatment targets are hampering the widespread use of these alternative tests.…”

Section: What Is the Next Investigation When A Discordant Hba1c And Gmentioning

confidence: 99%

Monitoring glycaemic control in patients with diabetes mellitus

Sodi

McKay²,

Dampetla

et al. 2018

BMJ

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“…FA was measured using a colorimetric assay with an inter‐assay CV of 3% on the Roche Modular P Chemistry Analyzer (Roche Diagnostics Corporation). The normal reference range for FA is 205 to 285 μmol/L . Because FA originates from non‐enzymatic glycation of proteins, it is both glucose and protein concentration dependent .…”

Section: Methodsmentioning

confidence: 99%

“…The normal reference range for FA is 205 to 285 μmol/L. 20 Because FA originates from non-enzymatic glycation of proteins, it is both glucose and protein concentration dependent. 21 FA was corrected for albumin concentration with the following calculation: albumin-adjusted fructosamine (AAFA) = FA × 4/albumin.…”

Section: Laboratory Proceduresmentioning

confidence: 99%

Screening for cystic fibrosis‐related diabetes and prediabetes: Evaluating 1,5‐anhydroglucitol, fructosamine, glycated albumin, and hemoglobin A1c

et al. 2019

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Objective Dysglycemia is prevalent in cystic fibrosis (CF) but screening with annual oral glucose tolerance tests (OGTT) can be burdensome. We investigated alternate glycemic markers—hemoglobin A1c (HbA1c), 1,5‐anhydroglucitol (1,5AG), fructosamine (FA), and glycated albumin (GA)—as screening tests for CF‐related diabetes (CFRD) and pre‐diabetes (CFPD) in youth with CF as defined by the gold‐standard OGTT 2‐hour glucose (2hG). Methods Youth 10 to 18 years with CF had a 1,5AG, FA, GA, HbA1c, and 2‐hour OGTT collected. Correlations between all glycemic markers and 2hG were evaluated. Area under the receiver operative characteristic (ROC‐AUC) curves were generated. Optimal cut points for predicting CFPD (2hG ≥ 140 mg/dL) and CFRD (2hG ≥ 200 mg/dL) were determined. Results Fifty‐eight youth with CF were included (2hG < 140, n = 16; CFPD, n = 33; CFRD, n = 9; 41% male, mean ± SD age 14.2 ± 3.6 years, BMI z‐score 0.0 ± 0.8, % predicted forced expiratory volume in 1 second [FEV1] 89.9 ± 15.1, % predicted forced vital capacity [FVC] 103.2 ± 14.6). ROC‐AUC's for all alternate markers were low for CFPD (0.52‐0.67) and CFRD (0.56‐0.61). At a cut point of 5.5%, HbA1c had 78% sensitivity (95% CI: 0.45‐0.94) and 41% specificity (95% CI: 0.28‐0.55) for identifying CFRD, correlating to a ROC‐AUC of 0.61 (95% CI: 0.42‐0.8). Conclusions All alternate markers tested demonstrate poor diagnostic accuracy for identifying CFRD by 2hG.

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Establishment of Community-Based Reference Intervals for Fructosamine, Glycated Albumin, and 1,5-Anhydroglucitol

Cited by 64 publications

References 33 publications

Reference intervals for serum 1,5‐anhydroglucitol of a population with normal glucose tolerance in Jiangsu Province

Reference intervals for serum 1,5‐anhydroglucitol of a population with normal glucose tolerance in Jiangsu Province

Monitoring glycaemic control in patients with diabetes mellitus

Screening for cystic fibrosis‐related diabetes and prediabetes: Evaluating 1,5‐anhydroglucitol, fructosamine, glycated albumin, and hemoglobin A1c

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