Establishment of an Acute Superior Mesenteric Artery Injury Model for Damage Control Surgery

Ding, Weiwei; Wu, Xingjiang; Gong, Guanwen; Meng, Qingxin; Ni, Lideng; Li, Jieshou

doi:10.1016/j.jss.2008.02.058

Cited by 12 publications

(7 citation statements)

References 60 publications

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“…Twenty-eight domestic female pigs (weight 23.8 6 4.6 kg) were used for the study, whose vascular systems were very close to human. After preparation, a transected SMA injury model was developed as described previously [19]. Briefly, through a midline laparotomy, the splenectomy was performed to reduce autotransfusion during hemorrhage.…”

Section: Animal Modelmentioning

confidence: 99%

“…To compensate the splenic blood loss, warm lactated Ringer's solution at a volume three times the organ's weight was infused [20]. Surgical exposure of SMA was accomplished by approaching the vessel directly at the root of the mesocolon [19]. The proximal trunk was isolated and clamped with two atraumatic bulldogs.…”

Section: Animal Modelmentioning

confidence: 99%

“…Ischemia/reperfusion injury of the gut invariably leads to loss of intestinal barrier functions. In a previous study, we successfully developed a hypothermic traumatic shock swine model of SMA injury [19]. In the present study we aimed to determine which of the three surgical operations brought the minimal ischemia reperfusion injury in a hypothermic traumatic shock model.…”

Section: Introductionmentioning

confidence: 96%

See 2 more Smart Citations

Comparisons of Three Surgical Procedures on Intestine Ischemia Reperfusion Injury in a Superior Mesenteric Artery Injury Model

Ding

et al. 2011

Journal of Surgical Research

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Section: Animal Modelmentioning

confidence: 99%

Section: Animal Modelmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

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Comparisons of Three Surgical Procedures on Intestine Ischemia Reperfusion Injury in a Superior Mesenteric Artery Injury Model

Ding

et al. 2011

Journal of Surgical Research

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“…18 H12-(ADP)-liposomes may help hemostasis as an alternative to platelets in prehospital or urgent situations. 14,19 Despite several trials, [20][21][22] an appropriate animal model of abdominal vascular injury complicated with severe acidosis and coagulopathy has not been provided. Therefore, we established a model of hemorrhagic shock with coagulopathy by vessel injury, based on our previous study.…”

Section: Introductionmentioning

confidence: 99%

H12‐(ADP)‐liposomes for hemorrhagic shock in thrombocytopenia: Mesenteric artery injury model in rabbits

Hagisawa

Kinoshita

Takeoka

et al. 2022

Research and Practice in Thrombosis and Haemostasis

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Background Damage control resuscitation improves patient outcomes after severe hemorrhage and coagulopathy. However, effective hemostasis methods for these critical situations are lacking. Objective We evaluated the hemostatic efficacy of fibrinogen γ‐chain (HHLGGAKQAGDV, H12)‐coated, adenosine‐diphosphate (ADP)‐encapsulated liposomes (H12‐[ADP]‐liposomes) in thrombocytopenic rabbits with hemorrhagic shock. Methods Acute thrombocytopenia (80%) was induced in rabbits that also received mesenteric vessel injury, leading to hemorrhagic shock. Five minutes after injury, subjects received intravenous bolus injection with H12‐(ADP)‐liposomes (20 mg/kg), followed by isovolemic transfusion with stored red blood cells (RBCs)/platelet poor plasma (PPP) (RBC:PPP = 1:1 [vol/vol]), or lactated Ringer solution every 5 min to compensate blood loss. One group received H12‐(phosphate buffered saline [PBS]) liposomes followed by RBC/PPP. Additional groups were received isovolemic transfusion with RBC/platelet rich plasma (PRP) (RBC:PRP = 1:1 [vol/vol]), RBC/PPP, PPP alone, or lactated Ringer solution. Results Treatment with H12‐(ADP)‐liposomes followed by RBC/PPP transfusion and RBC/PRP transfusion effectively stopped bleeding in all thrombocytopenic rabbits. In contrast, three of 10 rabbits treated with RBC/PPP failed hemostasis, and no rabbits receiving lactated Ringer solution stopped bleeding or survived. Twenty‐four hours after hemorrhage, 80% of rabbits receiving H12‐(ADP)‐liposome followed by RBC/PPP transfusion survived and 70% of rabbits receiving RBC/PRP transfusion also survived, although RBC/PPP‐transfused rabbits showed 40% survival. Rabbits receiving H12‐(ADP)‐liposomes followed by lactated Ringer solution showed a transient hemostatic potential but failed to survive. H12‐(PBS)‐liposomes showed no beneficial effect on hemostasis. Neither the PPP group nor the lactated Ringer group survived. Conclusion H12‐(ADP)‐liposome treatment followed by RBC/PPP may be effective in lethal hemorrhage after mesenteric vessel injury in coagulopathic rabbits.

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“…This is due to the fact, that any surgical intervention in the intestine is associated with a disorder of its blood supply [1,2] . One of the important factors in the pathogenesis of damage is ischemia, result in a disruption of the structural and functional tissues organization, especially at an early age [3][4][5] . Numerous studies established quite a variety of functional and morphological changes in ischemia, causing, mainly, the complex relationships of neuro-reflex, hemodynamic, metabolic and biological reactions [6,7] .…”

Section: Introductionmentioning

confidence: 99%

Homeostasis Change in the Small Intestine With Disturbed Regional Blood Flow in Early Postnatal Ontogenesis

Markosyan¹

2018

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Objective: A study of the ischemic damage course and regeneration in the small intestine with disturbed regional blood flow in early postnatal ontogenesis.Materials and Methods: The experiments were carried out on 30 puppies at the age from 1 to 4 weeks. The state of regional blood flow in the ischemic area of the small intestine was investigated by blood filling of tissues, metabolism - by redox potential, oxygen pressure and diffusion oxygen coefficient, lipid peroxidation activity and catalase activity. Database formation and statistical calculations were performed using the applied programmes "Microsoft Excel", "ANOVA" for "Windows".Results: The performed research showed that in animals of early age pronounced microcirculatory disorders were observed. About this evidenced significant tissue bloodfilling in the ischemic region of the small intestine. Essential disorder of the blood supply in the organ naturally led to a pronounced fall in the redox potential, the oxygen pressure, and the diffusion oxygen coefficient in the tissues.On a level with the disturbances in the electrogenesis and tissue oxygenation, we found a significant diminution in their antioxidant capacity, as evidenced by a pronounced increase in lipid peroxidation and a decrease in catalytic activity. Insufficient oxygen supply of tissues caused the development of irreversible changes in the intestinal wall, the disorder of the organ motility with frequent appearance of small intestinal intussusception.Conclusions: A significant disturbance of the small intestine blood supply at the early age, caused by an operating trauma, leads to a pronounced decrease in electrical activity and oxygenation of the organ tissues, accompanied by marked metabolic disorders.Oxygen starvation of tissues in the ischemic region of the small intestine at the early age contributes to the development of irreversible changes in the intestinal wall, and frequent disruption of the regeneration process in this area. Keywords: small intestine; local ischemia; early age

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Establishment of an Acute Superior Mesenteric Artery Injury Model for Damage Control Surgery

Cited by 12 publications

References 60 publications

Comparisons of Three Surgical Procedures on Intestine Ischemia Reperfusion Injury in a Superior Mesenteric Artery Injury Model

Comparisons of Three Surgical Procedures on Intestine Ischemia Reperfusion Injury in a Superior Mesenteric Artery Injury Model

H12‐(ADP)‐liposomes for hemorrhagic shock in thrombocytopenia: Mesenteric artery injury model in rabbits

Homeostasis Change in the Small Intestine With Disturbed Regional Blood Flow in Early Postnatal Ontogenesis

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