Establishment of a validated central reading system for ileocolonoscopy in an academic setting

Abstract

This is a repository copy of Establishment of a validated central reading system for ileocolonoscopy in an academic setting.

A biomarker-stratified comparison of top-down versus accelerated step-up treatment strategies for patients with newly diagnosed Crohn's disease (PROFILE): a multicentre, open-label randomised controlled trial

“…The hierarchical secondary endpoints were: (1) endoscopic remission at week 48 defined by absence of ulceration (including aphthous ulceration)—ie, SES-CD ulcer subscore of 0—based on centrally read endoscopic scores, 19 or where ileo-colonoscopies had not been video-recorded, locally read SES-CD scores; (2) quality of life assessment averaged across weeks 16, 32, and 48 using the IBD-Q score; (3) number of flares requiring treatment escalation by week 48; (4) cumulative steroid exposure by week 48; and (5) the number of Crohn's-related hospital admissions and surgeries by week 48.…”