Establishment of a Stringent Large Animal Model of Insulin-Dependent Diabetes for Islet Autotransplantation

Pepper, Andrew R.; Welch, I M; Bruni, Anthony; MacGillivary, Amanda; Mazzuca, Delfina M.; White, David J.; Wall, William

doi:10.1097/mpa.0b013e318264bcdd

Cited by 5 publications

(1 citation statement)

References 28 publications

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“…DM1 pathophysiology has been extensively studied through several models. Chemical induction of diabetes has already been performed in rats (Dordevic et al, 2017;Eleazu et al, 2017;Gite et al, 2017;Nazratun et al, 2017;Pipkin et al, 2017), mice (Chen et al, 2017), Brazilian Journal of Development, Curitiba, v.7, n.12, p. 115094-115110 dec. 2021 Zebrafish (Leontovich et al, 2016), monkeys (Park et al, 2017) and pigs (Hiridis, 2016;Pepper, 2013).…”

Section: Introductionmentioning

confidence: 99%

Eurythrematosis as a developmental model of the Diabetes Mellitus type 1 pathological condition: pathophysiological parameters and oxidative stress / Eurytrematose como modelo de desenvolvimento da patologia da Diabetes Mellitus tipo 1: parâmetros fisiopatológicos e stress oxidativo

Rosa¹,

Nodari²,

Suthovski³

et al. 2021

BJDV

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Eurytrematosis is a helminthic disease caused by trematodes belonging to the genus Eurytrema spp. that parasitize the pancreas of many animals and humans. This parasitosis causes chronic fibrosing pancreatitis, fat infiltration in the pancreatic parenchyma, besides damaging the exocrine pancreas, which is similar to that found in patients with Diabetes Mellitus type 1 (DM1). The current work aimed to evaluate the use of bovine pancreas infected with E. coelomaticum as a model to study DM1 pathophysiology. It was carried out macroscopic analyses, parasite identification, total pancreatic lipid determination and oxidative damage biomarkers levels of pancreas naturally infected with E. coelomaticum. Macroscopically, we observed that the infected pancreas had duct obstruction, organ stiffness due to the visible presence of fibrosis, increased adipose tissue deposition, increased protein and lipid damage, as well as increased antioxidant biomarkers (GSH, CAT and VIT C). Thus, it is possible to show that DM1 may have pancreatic parasitism as a possible primary origin. However, more studies are needed to better investigate this possible primary origin; the results obtained here suggest that the use of pancreas parasitized by E. coelomaticum could be a model to investigate DM1 pathophysiology.

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Section: Introductionmentioning

confidence: 99%

Eurythrematosis as a developmental model of the Diabetes Mellitus type 1 pathological condition: pathophysiological parameters and oxidative stress / Eurytrematose como modelo de desenvolvimento da patologia da Diabetes Mellitus tipo 1: parâmetros fisiopatológicos e stress oxidativo

Rosa¹,

Nodari²,

Suthovski³

et al. 2021

BJDV

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Preliminary Results of the Influence of Duodenojejunal Bypass in a Porcine Model of Streptozotocin-Induced Diabetes Mellitus

et al. 2016

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