Establishment of a pretreatment method for tetracycline production wastewater using enhanced hydrolysis

Anaerobic treatment of antibiotic production wastewater pretreated with enhanced hydrolysis: Simultaneous reduction of COD and ARGs

“…The hydrolysis kinetics of oxytetracycline were investigated over a temperature range of 25 Ce85 C and pH range of 5e11 (Table 1). Similar to our previous study, which investigated the hydrolysis kinetics of tetracycline (Yi et al, 2016), the hydrolysis rate increased significantly with the increase of temperature. The half-life (t 1=2 ) of oxytetracycline drastically decreased from 173.17 h to 0.19 h when the temperature was increased from 25 C to 85 C at pH 7.…”

“…68.9% was achieved at the OLR of 3.3, 4.8 and 5.9 kg m À3 d À1 in the anaerobic reactor. Our previous study using batch testing demonstrated that anaerobic treatment of tetracycline production wastewater was feasible once enhanced hydrolysis pretreatment was conducted (Yi et al, 2016). This is the first time to demonstrate that the enhanced hydrolysis as a pretreatment method could permit an efficient engineering anaerobic treatment of wastewater containing high concentrations of oxytetracycline.…”

“…On the other hand, many antibiotics are susceptible to hydrolysis in aqueous solution, though the hydrolysis half-lives range from days to weeks under normal conditions (Loftin et al, 2008;Mitchell et al, 2014). For the first time, our previous study has shown that tetracycline and its antibacterial potency could be effectively removed within several hours using enhanced hydrolysis by elevating temperature and pH (Yi et al, 2016). Batch test results showed that the suppression of anaerobic digestion activity by tetracycline could be removed after the enhanced hydrolysis, showing the high potential of this process as a pretreatment approach for the biological treatment of APW.…”

Effect of Antibiotics on the Microbial Efficiency of Anaerobic Digestion of Wastewater: A Review

“…For instance, terramycin reduced the cumulative methane production by 23.75% at 35°C ( Arikan et al, 2006 ), while at 55°C, the same concentration of terramycin did not inhibit anaerobic digestion ( Alonso et al, 2019 ). On the contrary, the inhibition of anaerobic digestion by tetracycline increases with temperature ( Diehl and LaPara, 2010 ; Yi et al, 2016 ). Here, it is speculated that terramycin is likely to be hydrolyzed at higher temperature, thus in turn losing its inhibitory capacity.…”

Pilot-Scale Hydrolysis-Aerobic Treatment for Actual Municipal Wastewater: Performance and Microbial Community Analysis

“…Hydrolysis has been used for a lot of refractory feed, including both solid and liquid waste such as lignocellulosic biomass (e.g., sugarcane bagasse and rice straw) [ 8 ], excess sludge [ 9 ], food waste [ 10 ] and refractory/particulate-rich wastewater from tanneries [ 11 ] and the petrochemical industry [ 12 ]. The inhibiting issue of the antibiotic (e.g., tetracycline) production of wastewater for the following biological process could be avoided through the use of hydrolysis with a BOD/COD ratio increase [ 13 ]. Moreover, hydrolysis is based on anaerobes with no aeration and no additional heating requirements, indicating its low-energy cost for large-volume municipal wastewater treatment.…”