Abstract:Copper is of great importance for the normal brain. Excess of copper results in neurodegenerative diseases such asAlzheimer's disease (AD). The pathological hallmarks of AD are the amyloid-β (Aβ) peptides. Aβ peptides have been shown to bind copper with high affinity. We established a new rat model of AD by using copper sulfate (CuSO 4 ) solution with several doses and for different periods of time. The rats were randomly divided into normal control groups and AD groups. All rats underwent behavioral, histopat… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.