Establishment of a Model to Objectively Examine Maximal Nasal Decongestion Using a Clinically Available Antihistamine/decongestant

Romero, F.A.; Phillips, Peter G.; Norris, Virginia; Turner, Kristy L.; Hutchinson, K.; Allan, Richard; Tan, Esp; Misfeldt, Janie; Ward, Jonathan K.; Casale, Thomas B.

doi:10.1016/j.jaci.2007.12.1095

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2012

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“…A response to the allergen (as evidenced by a reduction in A min and nasal volume values) was seen in all treatment groups, but there was no significant treatment effect on A min proportion or nasal volume proportion for any treatments, including fexofenadine/pseudoephedrine. On the basis of a previous allergen challenge methodology study 11 in which fexofenadine/pseudoephedrine partially attenuated allergen-induced reduction of A min and nasal volume values, the lack of statistically significant inhibition was not expected. Indeed, the same general methodology was used in both studies.…”

Section: Discussionmentioning

confidence: 90%