Establishment of a lethal mouse model of emerging tick-borne orthonairovirus infections
Takuma Ariizumi,
Koshiro Tabata,
Yukari Itakura
et al.
Abstract:Emerging and reemerging tick-borne orthonairovirus infections (family Nairoviridae), which are genetically distinct from Crimean-Congo hemorrhagic fever virus, have been recently reported in East Asia. Here, we have established a mouse infection model using type-I/II interferon receptor-knockout mice (AG129) both for a better understanding the pathogenesis of these infections and validation of antiviral agents using Yezo virus (YEZV), a novel virus causing febrile illnesses associated with tick bites in Japan … Show more
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