Establishment of a follicular lymphoma cell line (FLK-1) dependent on follicular dendritic cell-like cell line HK

Duodenal and nodal follicular lymphomas are distinct: the former lacks activation-induced cytidine deaminase and follicular dendritic cells despite ongoing somatic hypermutations

“…23 In nodal follicular lymphoma, follicular dendritic cells were important to the microenvironment in which follicular lymphoma cells grow. 24 As shown in the results, although follicular dendritic cell networks were located at the periphery of neoplastic follicles, the major center part of follicular dendritic cells looked broken except for in two samples; by contrast, all nodal lymphomas showed extensively distributed follicular dendritic cells. The shape of degraded follicular dendritic cells are somewhat similar to the follicular colonization of MALT lymphomas, in which marginal zone B-cell lymphoma cells penetrate the non-neoplastic germinal centers and destroy follicular dendritic cell networks (Figure 4).…”

Splenic CD19−CD35+B220+ cells function as an inducer of follicular dendritic cell network formation

“…The strong association of classic FDC/FDC-like cells with stromal cells has not been described elsewhere. 27,[38][39][40] Moreover, they possess stromallike fibroblastic or dendritic appearance, in contrast to CD35 ϩ B220 ϩ cells ( Figure 1C; Figure S2). However, as shown in Figure 3 and Figure S3, CD35 ϩ B220 ϩ cells and stromal cells efficiently interact with each other, resulting in the appearance of double-nuclear cells of stromal origin (ie, GFP ϩ ) that acquire the surface phenotype of CD35 ϩ B220 ϩ cells.…”

Follicular Dendritic Cell Dedifferentiation by Treatment with an Inhibitor of the Lymphotoxin Pathway Dramatically Reduces Scrapie Susceptibility

“…Also, FDC-associated human immunodeficiency virus particles comprise a major viral reservoir in infected patients (8), and removal may improve the efficacy of antiviral therapies. Moreover, the elimination of FDCs may reduce the survival of some lymph node-resident lymphomas that require FDCs for their survival (22,29). Current evidence suggests that the human TSE disease, vCJD, shares a similar requirement for FDCs in its pathogenesis, since PrP Sc is associated with FDCs in lymphoid tissues from infected patients (24) and has been detected in the appendix prior to the onset of clinical disease (26,27).…”