Establishment of a fast and high yield method for routine production of [¹³¹I]MIBG and investigation of its radiochemical stability for diagnosis and treatment uses

Abstract

In this work, exchange radioiodination of metaiodobenzylguanidine (MIBG) was carried out at optimum conditions that facilitates the production of [(131) I]MIBG both quickly and efficiently. The radiochemical purity and yield of the labeled product are typically as high as 99% and 90% for diagnostic dose and 95% and 80% for therapeutic dose, respectively. Stability studies show that labeled material at the room temperature met the demand of the clinical application. This labeling procedure will be used in the routine production process of [(131) I]MIBG for diagnosis and treatment uses.

Production and Clinical Applications of Radiopharmaceuticals and Medical Radioisotopes in Iran

“…Tc-UBI Production. Ubiquicidin (UBI) [29][30][31][32][33][34][35][36][37][38][39][40][41] (TGRAKRRMQYNRR, 1693 Da) is a synthetic cationic chemotactic peptide that preferentially binds to bacterial cell membrane at the site of infection with high sensitivity and specificity. The radioactive peptide was totally synthesized and formulated by the investigators in the country.…”

“…Tc-UBI [29][30][31][32][33][34][35][36][37][38][39][40][41] in differentiation of orthopedic implant infection from sterile inflammation. Nine patients with orthopedic device implants underwent dynamic followed by static whole-body imaging after intravenous (IV) injection of 10 MBq/kg 99m Tc-UBI [29][30][31][32][33][34][35][36][37][38][39][40][41]. Considering bacterial culture from periprosthetic tissue as gold standard, they yielded 100% sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and diagnostic accuracy.…”

“…They stated that these results might be influenced by the fact that all cultures were positive for only Staphylococcus aureus, and diagnostic accuracy would become lower if microorganisms with lower affinity for 99m Tc-UBI (eg, E. coli) were present at cultures. In a study conducted by Doroudi et al, 17 10 diabetic patients with suspected infectious or sterile inflammation in feet, who have not received any antibiotic therapy underwent both three-phase 99m Tc-MDP scan and 99m Tc-UBI [29][30][31][32][33][34][35][36][37][38][39][40][41] scintigraphy. By comparison with culture results, combined techniques lead to a PPV of 100% for detection of infection in diabetic foot.…”

“…By comparison with culture results, combined techniques lead to a PPV of 100% for detection of infection in diabetic foot. Rapid distribution of 99m Tc-UBI [29][30][31][32][33][34][35][36][37][38][39][40][41] at the site of infection provided interpreters with early diagnosis of infectious process when interpreting the results with bone scan landmarks to differentiate bone from soft tissue infection. Another study by Fard-Esfahani et al 18 in evaluation of 99m Tc-UBI [29][30][31][32][33][34][35][36][37][38][39][40][41] scintigraphy in differentiation of bacterial infection from sterile inflammation in 15 patients with diabetic foot found a sensitivity of 40%.…”

“…Rapid distribution of 99m Tc-UBI [29][30][31][32][33][34][35][36][37][38][39][40][41] at the site of infection provided interpreters with early diagnosis of infectious process when interpreting the results with bone scan landmarks to differentiate bone from soft tissue infection. Another study by Fard-Esfahani et al 18 in evaluation of 99m Tc-UBI [29][30][31][32][33][34][35][36][37][38][39][40][41] scintigraphy in differentiation of bacterial infection from sterile inflammation in 15 patients with diabetic foot found a sensitivity of 40%. In another study, Assadi et al 19 evaluated and compared diagnostic value of 99m Tc-UBI [29][30][31][32][33][34][35][36][37][38][39][40][41] scintigraphy with 99m Tc-MDP scintigraphy and MRI.…”