Establishment of a Comprehensive List of Candidate Antiaging Medicinal Herb Used in Korean Medicine by Text Mining of the Classical Korean Medical Literature, “Dongeuibogam,” and Preliminary Evaluation of the Antiaging Effects of These Herbs

Abstract

The major objectives of this study were to provide a list of candidate antiaging medicinal herbs that have been widely utilized in Korean medicine and to organize preliminary data for the benefit of experimental and clinical researchers to develop new drug therapies by analyzing previous studies. “Dongeuibogam,” a representative source of the Korean medicine literature, was selected to investigate candidate antiaging medicinal herbs and to identify appropriate terms that describe the specific antiaging effects that these herbs are predicted to elicit. In addition, we aimed to review previous studies that referenced the selected candidate antiaging medicinal herbs. From our chosen source, “Dongeuibogam,” we were able to screen 102 terms describing antiaging effects, which were further classified into 11 subtypes. Ninety-seven candidate antiaging medicinal herbs were selected using the criterion that their antiaging effects were described using the same terms as those employed in “Dongeuibogam.” These candidates were classified into 11 subtypes. Of the 97 candidate antiaging medicinal herbs selected, 47 are widely used by Korean medical doctors in Korea and were selected for further analysis of their antiaging effects. Overall, we found an average of 7.7 previous studies per candidate herb that described their antiaging effects.

Chinese Herbal Medicines for Rheumatoid Arthritis: Text‐Mining the Classical Literature for Potentially Effective Natural Products

“…Along with the increasing application of clinical trial methodologies for the evaluation of traditional medicines for RA and other diseases, there has been increasing attention to the systematic assessment of the premodern and classical medical literature using text-mining approaches [20]. Such studies have focused on drug discovery from compounds found in the natural products used in traditional medicines [21][22][23]; identification of instances of long-term traditional use of natural products for certain diseases or symptoms [24][25][26][27]; the logic underlying ancient acupuncture prescriptions [28]; and investigations of continuities and differences between the classical and modern Chinese medicine approaches to certain diseases [29,30]. It has been proposed that long-term traditional use could be considered as a source of evidence [31], and a "whole-evidence" approach to evidencebased Chinese medicine could concludes systematic searching of the classical literature as one component [32].…”

Cognitive-Enhancing Herbal Formulae in Korean Medicine: Identification of Candidates by Text Mining and Literature Review

“…1 In brief, two steps were used. In the first step, the Dongui Bogam was screened for TCEHFs and CCEHFs and lists were generated.…”

“…In addition, previous studies focusing on those antiaging candidates were also reviewed. 1 That article focused only on individual medicinal herbs; the current study includes herbal formulae that enhance cognitive ability as an antiaging effect. Because the category of antiaging effects seemed too comprehensive, this report focuses on herbal formulae that enhance cognition.…”

Pretreatment with Shuanghe‐Tang Extract Attenuates Postischemic Brain Injury and Edema in a Mouse Model of Stroke: An Analysis of Medicinal Herbs Listed in Dongui Bogam

“…Indeed, researchers have begun to consult the traditional medicine literature in the search for novel therapeutic strategies [ 5 , 6 ]. Compiled by the Korean royal physician Heo Jun during the 17th century, the Dongui Bogam contains records regarding a number of prescriptions and systematic screening methods that have been applied to both experimental and clinical settings [ 7 , 8 ]. Researchers have suggested that the Pung chapter of the Dongui Bogam contains valuable information regarding herbal combinations that may aid in the development of novel stroke treatments [ 9 ].…”