Establishment of a clinician-led guideline on the diagnosis and treatment of Hirayama disease using a modified Delphi technique

Lyu, Feizhou; Zheng, Chaojun; Wang, Hongli; Nie, Cong; Ma, Xin; Xia, Xinlei; Zhu, Wei; Jin, Xiang; Hu, Yongcheng; Sun, Yu; Zhu, Yu; Kuwabara, Satoshi; Cortese, Rosa; Hassan, Kaukab Maqbool; Takai, Keisuke; Paredes, Igor; Webere, Robert; Turk, Margaret D; Kimura, Jun; Jiang, Jianyuan

doi:10.1016/j.clinph.2020.02.022

Cited by 34 publications

(57 citation statements)

References 64 publications

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“…The proposed criteria for the diagnosis were established by a clinician-led guideline for the diagnosis and treatment of HD using a modified Delphi technique published in 20202 and include the following:…”

Section: Discussionmentioning

confidence: 99%

Rare cause of unilateral upper limb weakness in a young adolescent

Kumar

Prochoroff

2020

BMJ Case Rep

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Slowly progressing unilateral upper limb weakness in a previously healthy child can occur due to number of causes which requires a thorough history, physical examination followed by radiological examination, electromyography and so on. Among the various aetiologies, a rare condition such as Hirayama disease is one of the differentials to be considered. There has been a wealth of literature reported on this disease and our case is a learning lesson for all paediatricians to be aware of Hirayama disease and its current concepts.

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Section: Discussionmentioning

confidence: 99%

Rare cause of unilateral upper limb weakness in a young adolescent

Kumar

Prochoroff

2020

BMJ Case Rep

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“…The study involved male HD patients diagnosed at our hospital from June 2017 to February 2020. The diagnostic criteria is the clinical diagnosis of Hirayama disease (1,(19)(20)(21)(22), these include adolescent onset, manifestation of unilateral upper limb muscle weakness, and muscle atrophy of the forearm and hand. Accompanying symptoms include cold paralysis and tremor-like movement of ngers when stretched.…”

Section: Methodsmentioning

confidence: 99%

Evaluation of Correlation between the Cross-sectional Area of Posterior Cervical Extensor Muscles and Cervical Sagittal Alignment in Patients with Hirayama Disease

Tian

Xie

Jang

et al. 2021

Preprint

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Purpose: To assess correlation between the cross-sectional area (CSA) of posterior cervical extensor muscles (PCEMs) and the cervical sagittal alignment in Hirayama disease (HD) patients.Methods: We analyzed the MRI (Magnetic resonance imagine) T2WI and X-rays of 60 male HD patients who visited our hospital from June 2017 to February 2020. Their mean age was 18.95±1.67 years (range 16-22 years). MRI image is used to measure the CSA of cervical PCEMs. The ratio of muscle CSA to vertebral body areas (VBA) at the same level is defined as R-CSA. Cervical sagittal alignment includes C2-7 cobb angle, T1 slope, and C2-7 sagittal vertical axis (SVA). The geometric center of the C3-6 vertebral body was determined using the line connecting the C2 inferior endplate and the C7 upper endplate. When located behind the line, it is defined as a “Local kyphotic deformity” (LKD). The number of vertebral bodies involved in kyphotic deformity was determined by Local kyphosis angle (LKA) measured. Spearman correlation analysis (α=0.05) was used to determine the relationship between R-CSA and sagittal parameters. Results: Spearman correlation test revealed that R-CSA negatively correlated with T1S (S=0.34, p=0.01) and LKA (S=0.44, p=0.01) but did not correlated with C2-C7 cobb angle (S= 0.20, p=0.12) or C2-C7 SVA (S=-0.17, p=0.46). (p＜0.05)Conclusions: In Hirayama disease, the CSA of PCEMs is related to T1s and LKA and exercising the PCEMs should be given enough attention.

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“…Hirayama disease is a special neurological disorder, predominantly affecting male adolescents. Thus, non-degenerative NP tissues could be obtained from patients undergoing anterior cervical discectomy and fusion due to this disease ( 62 ). We previously showed that circERCC2 expression was significantly downregulated in IDD tissues compared with that in Hirayama disease samples ( 25 ).…”

Section: Roles Of Circrna In Mitophagymentioning

confidence: 99%

Roles of circular RNAs in the pathogenesis of intervertebral disc degeneration (Review)

Lin

et al. 2021

Exp Ther Med

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Lower back pain (LBP) is an extremely common symptom and is recognized as a leading contributor to disability and disease burden globally. Intervertebral disc degeneration (IDD) represents a major cause of LBP. However, the molecular mechanisms involved in the pathogenesis of IDD remain unclear, and currently available treatments, including conservative and surgical options, fail to effectively delay, stop or reverse the progression of IDD. Circular RNAs (circRNAs) are a newly discovered group of covalently closed, single-stranded and endogenous non-coding RNAs. A growing body of research has revealed that a number of circRNAs are widely and aberrantly expressed in IDD tissues. Furthermore, they play important roles in the pathogenesis of IDD, including proliferation, apoptosis, senescence, mitophagy, inflammation and extracellular matrix metabolism, mainly by acting as sponges for microRNAs. The present review aims to summarize the current understanding on the mechanisms of circRNA-mediated regulation in IDD.

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Establishment of a clinician-led guideline on the diagnosis and treatment of Hirayama disease using a modified Delphi technique

Cited by 34 publications

References 64 publications

Rare cause of unilateral upper limb weakness in a young adolescent

Rare cause of unilateral upper limb weakness in a young adolescent

Evaluation of Correlation between the Cross-sectional Area of Posterior Cervical Extensor Muscles and Cervical Sagittal Alignment in Patients with Hirayama Disease

Roles of circular RNAs in the pathogenesis of intervertebral disc degeneration (Review)

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